RestrictedBinding ruleINOriginal is EnglishOfficial-source import checked

C -alkyltrimethy 16 lammonium chloride 21 Cetrimonium Chloride ( ) (CAS No. 112-02-7) C -alkyltrimethyl 18 ammonium chloride 21 Steartrimonium chloride ( ) (CAS No. 112-03-8)

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.
Conditions and restrictions
Field of application/use: a)Rinse-off hair products b)Leave-on hair products c)Leave-on face products | Maximum authorised concentration: a)2.5 percent for the individual concentra- tions or the sum of the individual concentra- tions of cetrimonium chloride and streartrimo- nium chloride b)1.0 percent for the individual concentra- tions or the sum of the individual concentra- tions of cetrimonium chloride and streartrimo- nium chloride; and c)0.5percent for the individual concentra- tions or the sum of the individual concentra- tions of cetrimonium chloride and streartri- monium chloride. | Other limitations/requirements: For purposes other than inhibiting the development of microorganisms in the product. The purpose has to be apparent from the presentation of the product.

Substance identity

Official source name
C -alkyltrimethy 16 lammonium chloride 21 Cetrimonium Chloride ( ) (CAS No. 112-02-7) C -alkyltrimethyl 18 ammonium chloride 21 Steartrimonium chloride ( ) (CAS No. 112-03-8)
CAS
112-02-7; 112-03-8
EC
203-928-6
Identity mapping
cas_number
Linked ingredient
CETRIMONIUM CHLORIDE

Linked CosIng identity data

Names and aliases

CETRIMONIUM CHLORIDE

CosIng description: 1-Hexadecanaminium, N,N,N-trimethyl-, chloride

EU inventory restriction note: V/44

Recorded cosmetic function: ANTIMICROBIAL, ANTISTATIC, PRESERVATIVE, SURFACTANT - EMULSIFYING

Function pages:ANTIMICROBIAL, ANTISTATIC, PRESERVATIVE, SURFACTANT, SURFACTANT - EMULSIFYING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

7 market datasets

New Zealand

Permitted list with conditionsRestricted

4 linked records · 4 with specific conditions

Open supporting record

ASEAN

Permitted list with conditionsRestricted

2 linked records · 2 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 112-02-7
CAS 112-02-7PubChem CID 8154

Verified chemistry for CAS 112-02-7

Hexadecyltrimethylammonium chloride

Cetyltrimethylammonium chloride is the organic chloride salt of cetyltrimethylammonium. It has a role as a surfactant. It is a quaternary ammonium salt and an organic chloride salt. It contains a cetyltrimethylammonium ion. ChEBI

IUPAC name
hexadecyl(trimethyl)azanium chloride
Molecular formula
C19H42ClN
Molecular weight
320.0 g/mol
Exact mass
319.3005780 Da
Monoisotopic mass
319.3005780 Da
Topological polar surface area
0.0 Ų
Molecular complexity
181.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
15
Heavy atoms
21
Covalent units
2

Names and synonyms reported to PubChem

Cetrimonium chlorideN-Hexadecyltrimethylammonium chlorideDehyquart AGenamin CTACAliquat 6Cetyl trimethyl ammonium chlorideCETACHTAC
16 more reported names
Adogen 444Surfroyal CTACMorpan CHAQuartamin 60WTrimethylcetylammonium chlorideArquad 16-29Arquad 16-50Ammonyx Cetac 30TRIMETHYLHEXADECYLAMMONIUM CHLORIDEIntexsan CTC 29Intexsan CTC 50Arquad 16Barquat CT 29Intexan CTC 29Palmityltrimethylammonium chlorideVariquat E 228
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CCCCCCCCCCCCCCCC[N+](C)(C)C.[Cl-]
InChI
InChI=1S/C19H42N.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4;/h5-19H2,1-4H3;1H/q+1;/p-1
InChIKey
WOWHHFRSBJGXCM-UHFFFAOYSA-M

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8154

Attributed physical-property, hazard, environmental and use annotations.

  • Boiling Point: 180 °F at 760 mmHg (isopropyl alcohol) (USCG, 1999) Source: CAMEO Chemicals
  • Density: 0.9 at 77 °F (approx.) (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
  • First Aid: INGESTION: do NOT induce vomiting; drink large quanities of fluid and call a physician immediately.; EYES: flush with water for at least 15 min. and call a physician.; SKIN: flush with water. (USCG, 1999) Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 0.5% (5 of 1105) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (49%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (28.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H314 (41.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H315 (52.3%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (85.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335 (44.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400 (99.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (40.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P361+P364, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1105 reports by companies from 42 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 5 of 1105 reports by companies.; There are 41 notifications provided by 1100 of 1105 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: NITE-CMC
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Cetrimonium Chloride... Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
  • Environmental Bioconcentration: An estimated BCF of 71 was calculated for trimethylhexadecylammonium chloride(SRC), using an estimated log Kow of 3.23(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.2X10+5(SRC), determined from a structure estimation method(2), indicates that trimethylhexadecylammonium chloride is expected to be immobile in soil(SRC). Volatilization of trimethylhexadecylammonium chloride from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.9X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Trimethylhexadecylammonium chloride is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.8X10-10 mm Hg(SRC), determined from a fragment constant method(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.2X10+5(SRC), determined from an estimation method(2), indicates that trimethylhexadecylammonium chloride is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.9X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 71(SRC), from its log Kow of 3.23(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is moderate. The MITI, closed bottle, and Sturm tests revealed no degradation after 10 days, microbial growth after 17 days, and 84% degradation after 13 days, respectively(8). 10-20 ppm trimethylhexadecylammonium chloride was degraded with a half-life of 3.1 days in freshwater collected from the Ohio river 1 mile below discharge from a municipal treatment plant at 20 °C and pH 6.9(9). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethylhexadecylammonium chloride, which has an estimated vapor pressure of 2.8X10-10 mm Hg at 25 °C(SRC), using a fragment constant estimation method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase trimethylhexadecylammonium chloride may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Cleaning agent; Corrosion inhibitor; Softener and conditioner; Surface modifier; Surfactant (surface active agent) Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Corrosion inhibitor; Processing aids, specific to petroleum production; Softener and conditioner; Surface modifier; CBI; Processing aids not otherwise specified; Surfactant (surface active agent) Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 112-03-8
CAS 112-03-8PubChem CID 8155

Verified chemistry for CAS 112-03-8

Stearyltrimethylammonium chloride

Stearyltrimethylammonium chloride is an organic molecular entity. ChEBI

IUPAC name
trimethyl(octadecyl)azanium chloride
Molecular formula
C21H46ClN
Molecular weight
348.0 g/mol
Exact mass
347.3318782 Da
Monoisotopic mass
347.3318782 Da
Topological polar surface area
0.0 Ų
Molecular complexity
204.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
17
Heavy atoms
23
Covalent units
2

Names and synonyms reported to PubChem

Trimethylstearylammonium chlorideStacCation ABAliquat 7Nissan cation ABQuaternium-10Arquad 18Stearyl trimethyl ammonium chloride
16 more reported names
Arquad 18-50Monostearyl trimethyl ammonium chlorideN,N,N-Trimethyl-1-octadecanaminium chlorideRefChem:871332N,N,N-trimethyloctadecan-1-aminium chlorideTrimethyloctadecylammonium chlorideOCTADECYLTRIMETHYLAMMONIUM CHLORIDE1-Octadecanaminium, N,N,N-trimethyl-, chlorideSteartrimonium chlorideStearyl trimethyl ammoium chlorideOctadecy trimethyl ammonium chloridetrimethyl octadecyl ammonium chlorideOctadecyl trimethyl ammonium chloridetrimethyloctadecylamine, chloridetrimethyl(octadecyl)azanium;chlorideEINECS 203-929-1
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CCCCCCCCCCCCCCCCCC[N+](C)(C)C.[Cl-]
InChI
InChI=1S/C21H46N.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(2,3)4;/h5-21H2,1-4H3;1H/q+1;/p-1
InChIKey
VBIIFPGSPJYLRR-UHFFFAOYSA-M

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8155

Attributed physical-property, hazard, environmental and use annotations.

  • Carcinogen Classification: Not listed by IARC. Certain nitrosamines are classified by IARC as either probably or possibly carcinogenic to humans (Groups 2A and 2B, respectively). (L135) Source: Toxin and Toxin Target Database (T3DB)
  • Note: This chemical does not meet GHS hazard criteria for 3.7% (10 of 268) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (88.1%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (54.5%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H312 (19.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (79.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (29.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H400 (71.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (78.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P262, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 268 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 10 of 268 reports by companies.; There are 18 notifications provided by 258 of 268 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal] Source: NITE-CMC
  • Precautionary Statement Codes: P264, P270, P280, P301+P317, P302+P352, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Steartrimonium Chloride... Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: While quaternium-10 itself is not toxic, it is a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1889, L1890, A2878, A2879, A2880) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex B, entry 266
Source record ID
annex-b:266
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions

How this record fits the market dataset

1931
current India records
317
records marked Restricted
1931
records from this source version
1836
market records with CAS identity

Status distribution

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “C -alkyltrimethy 16 lammonium chloride 21 Cetrimonium Chloride ( ) (CAS No. 112-02-7) C -alkyltrimethyl 18 ammonium chloride 21 Steartrimonium chloride ( ) (CAS No. 112-03-8)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex B, entry 266, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

C -alkyltrimethy 16 lammonium chloride 21 Cetrimonium Chloride ( ) (CAS No. 112-02-7) C -alkyltrimethyl 18 ammonium chloride 21 Steartrimonium chloride ( ) (CAS No. 112-03-8). IS 4707 (Part 2):2025 Annex B, entry 266. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/16478/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source