CAS 10595-95-6PubChem CID 25418
N-Nitrosomethylethylamine
- IUPAC name
- N-ethyl-N-methylnitrous amide
- Molecular formula
- C3H8N2O
- Molecular weight
- 88.11 g/mol
- Exact mass
- 88.063662883 Da
- XLogP3
- 0.6
- Topological polar surface area
- 32.7 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 3
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
N-NitrosoethylmethylamineN-Methyl-N-nitrosoethanamineEthylmethylnitrosamineN-Nitroso-N-methylethylamineMethylethylnitrosamineMethylethylnitrosoamineN-Methyl-N-nitrosoethylamineNitrosoethylmethylamine
16 more reported names
Ethanamine, N-methyl-N-nitroso-Ethylamine, N-methyl-N-nitroso-N,N-MethylethylnitrosamineMethylaethylnitrosaminNitrosomethylethylamine00RLM29Y3AethylnitrosomethylamineRefChem:830860NMEAN-Ethyl-N-methylnitrosamineN-ethyl-N-methyl-nitrous amideethyl(methyl)nitrosoamineN-Nitroso-methyl ethylamineN-methyl-N-nitroso-ethanamineN-nitroso-methyl-ethylamineCCRIS 3058
External database identifiers
- ChEBI:CHEBI:82360
- ChEMBL:CHEMBL164852
- EPA DTXSID:DTXSID6021036
- PubMed:21819861
- PubMed:18648862
- PubMed:17904190
- PubMed:16599441
- PubMed:15619126
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:82360
N-Nitrosomethylethylamine
- Formula
- C3H8N2O
- Average mass
- 88.110 g/mol
- Monoisotopic mass
- 88.06366 Da
- Formal charge
- 0
- nitroso compound — is a (CHEBI:35800)
- nitroso compound — is a (CHEBI:35800)
Cross-references from this source
- CAS: 10595-95-6 — KEGG COMPOUND
- MANUAL_X_REF: C19281 — KEGG COMPOUND
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match25418
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 163 °C at 747 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 170 °C Source: Occupational Safety and Health Administration (OSHA)
- Color/Form: Yellow liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.9448 at 18 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 76 °C Source: Occupational Safety and Health Administration (OSHA)
- LogP: log Kow = 0.04 Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Yellow liquid; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Pale yellow oil. Source: Occupational Safety and Health Administration (OSHA)
- Solubility: Soluble in water (30%) and in organic solvents & lipids Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 1.1 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- IARC Carcinogenic Agent: N-Nitrosomethylethylamine Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 2B: Possibly carcinogenic to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 17: (1978) Some N-Nitroso Compounds; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1987 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1987 Source: International Agency for Research on Cancer (IARC)
- Note: This chemical does not meet GHS hazard criteria for 5.9% (3 of 51) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H301 (94.1%): Toxic if swallowed [Danger Acute toxicity, oral]; H315 (78.4%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (78.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (78.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351 (94.1%): Suspected of causing cancer [Warning Carcinogenicity] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 51 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 3 of 51 reports by companies.; There are 6 notifications provided by 48 of 51 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: NITE-CMC
- Precautionary Statement Codes: P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for N-nitrosomethylethylamine(SRC), using a log Kow of 0.04(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 43(SRC), determined from a structure estimation method(2), indicates that N-nitrosomethylethylamine is expected to have very high mobility in soil(SRC). Volatilization of N-nitrosomethylethylamine from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 1.44X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(2). N-Nitrosomethylethylamine is expected to volatilize from dry soil surfaces(SRC) based upon a an estimated vapor pressure of 1.1 mm Hg at 20 °C(3). Nitrosamines (such as N-nitrosomethylethylamine) photolyze rapidly in aqueous solution(4,5); therefore, photolysis is expected to occur on soil surfaces exposed to sunlight(SRC). N-Nitrosomethylethylamine has been shown to biodegrade slowly in anaerobic tests using digester sludge inocula(6). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 43(SRC), determined from a structure estimation method(2), indicates that N-nitrosomethylethylamine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected at occur slowly(3) based upon an estimated Henry's Law constant of 1.44X10-6 atm-cu m/mole at 25 °C(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 24 and 177 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of 3(SRC), from its log Kow of 0.04(5) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Nitrosamines (such as N-nitrosomethylethylamine) photolyze rapidly in aqueous solution(6); at a solar zenith angle of 40 deg N, the photolysis half-life of N-nitrosomethylethylamine and similar nitrosamines at the water's surface (exposed to full sunlight) is about 5.8 min(6). The direct photolysis rate constant for N-nitrosomethylethylamine in aqueous solution exposed to Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-nitrosomethylethylamine, which has an estimated vapor pressure of 1.1 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N-nitrosomethylethylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.6 days(SRC), calculated from its rate constant of 1.0X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Vapor-phase N-nitrosomethylethylamine may degrade readily via direct photolysis(SRC) based on rapid degradation in aqueous solution which has estimated half-lives of 5.8 minutes at a solar zenith angle of 40 deg N(4) and 15 minutes under California midsummer, midday sun irradiation(5). Source: Hazardous Substances Data Bank (HSDB)
- Sources/Uses: Used as a research chemical; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: RESEARCH CHEMICAL Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.