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CAS 100-75-4

CAS 100-75-4 matches 0 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 100-75-4
CAS 100-75-4PubChem CID 7526

N-Nitrosopiperidine

IUPAC name
1-nitrosopiperidine
Molecular formula
C5H10N2O
Molecular weight
114.15 g/mol
Exact mass
114.079312947 Da
XLogP3
0.4
Topological polar surface area
32.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Piperidine, 1-nitroso-NO-PipNPIPNitrosopiperidinN-Nitroso-piperidinnitrosopiperidineN-N-PipN-PIP
16 more reported names
TL 2666N066XUL4LNSC-138NSC138CHEBI:76324N-nitrosopentamethyleneimineRefChem:164027Hexahydro-N-nitroso-pyridine202-886-6RCRA waste number U179Pyridine, hexahydro-N-nitroso-1-Nitroso-piperidineNSC 138Nitrosopiperidin [German]CCRIS 477N-Nitroso-piperidin [German]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:76324

N-nitrosopiperidine

A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite.

Formula
C5H10N2O
Average mass
114.148 g/mol
Monoisotopic mass
114.07931 Da
Formal charge
0
  • nitrosamine — is a (CHEBI:35803)
  • piperidine — is a (CHEBI:18049)
  • carcinogenic agent — has role (CHEBI:50903)
  • apoptosis inducer — has role (CHEBI:68495)
  • mutagen — has role (CHEBI:25435)
  • environmental contaminant — has role (CHEBI:78298)
  • carcinogenic agent — has role (CHEBI:50903)
  • apoptosis inducer — has role (CHEBI:68495)
  • mutagen — has role (CHEBI:25435)
  • environmental contaminant — has role (CHEBI:78298)
  • nitrosamine — is a (CHEBI:35803)
  • piperidine — is a (CHEBI:18049)
Additional curated names
1-nitrosopiperidineN-nitrosohexahydropyridineNO-Pip
Cross-references from this source
  • CAS: 100-75-4 — ChemIDplus
  • CAS: 100-75-4 — NIST Chemistry WebBook
  • CAS: 100-75-4 — KEGG COMPOUND
  • REGISTRY_NUMBER: 110253 — Reaxys
  • MANUAL_X_REF: C19284 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-07-28. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7526

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 2% (1 of 51) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (98%): Toxic if swallowed [Danger Acute toxicity, oral]; H351 (92.2%): Suspected of causing cancer [Warning Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 51 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 51 reports by companies.; There are 4 notifications provided by 50 of 51 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for N-nitrosopiperidine(SRC), using a log Kow of 0.36(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that N-nitrosopiperidine is expected to have moderate mobility in soil(SRC). Volatilization of N-nitrosopiperidine from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 8.44X10-7 atm-cu m/mole(3). N-Nitrosopiperidine is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 9.20X10-2 mm Hg at 20 °C(4). A 33% biodegradation in 30 days(5) suggests that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that N-nitrosopiperidine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 8.44X10-7 atm-cu m/mole(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.36(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Under conditions simulating Southern California midsummer, midday sun, N-nitrosopiperidine exhibited an aqueous photolysis half-life of 12 minutes(7). A 33% biodegradation in 30 days(8) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-nitrosopiperidine, which has a vapor pressure of 9.20X10-2 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N-nitrosopiperidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 2.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). N-Nitrosopiperidine has a UV absorption maximum of 337 nm in water(4), and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 100-75-4

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CAS 100-75-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 0 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

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