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Dichloroethanes

Canada Hotlist: Dichloroethanes

Health Canada lists this ingredient as prohibited for use in cosmetic products.

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Regulatory decision and full conditions

Status
Prohibited
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as prohibited for use in cosmetic products.
Conditions and restrictions
Synonyms or related compounds: Ethylene chlorides

Substance identity

Official source name
Dichloroethanes
CAS
1300-21-6; 107-06-2
EC
203-458-1 / 215-077-8
Identity mapping
cas_number
Linked ingredient
ETHYLENE DICHLORIDE
Search this identity across the siteCAS 1300-21-6CAS 107-06-2EC 203-458-1EC 215-077-8

Linked CosIng identity data

Names and aliases

ETHYLENE DICHLORIDE

EU inventory restriction note: II/125

Recorded cosmetic function: NOT REPORTED

Function pages:NOT REPORTED

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 107-06-2
CAS 107-06-2PubChem CID 11

Verified chemistry for CAS 107-06-2

1,2-Dichloroethane

1,2-dichloroethane is a member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2. It has a role as a mutagen, a non-polar solvent and a hepatotoxic agent. — ChEBI

IUPAC name
1,2-dichloroethane
Molecular formula
C2H4Cl2
Molecular weight
98.96 g/mol
Exact mass
97.9690055 Da
Monoisotopic mass
97.9690055 Da
XLogP3
1.5
Topological polar surface area
0.0 Ų
Molecular complexity
6.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Rotatable bonds
1
Heavy atoms
4
Covalent units
1

Names and synonyms reported to PubChem

Ethylene dichlorideEthylene chlorideGlycol dichlorideDutch liquidEthane, 1,2-dichloro-Ethane dichloridesym-DichloroethaneAethylenchlorid
16 more reported names
BrocideDichlor-Mulsion1,2-DichlorethaneDichloro-1,2-ethaneDichloremulsionalpha,beta-Dichloroethane1,2-BichloroethaneBorer solBichlorure D'ethyleneDi-chlor-mulsionFreon 150Destruxol borer-sol1,2-DCE1,2-Ethylene dichlorideEthyleendichlorideCloruro di ethene
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
0
3D rings
0
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
3
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
C(CCl)Cl
InChI
InChI=1S/C2H4Cl2/c3-1-2-4/h1-2H2
InChIKey
WSLDOOZREJYCGB-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:27789

1,2-dichloroethane

A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.

Formula
C2H4Cl2
Average mass
98.960 g/mol
Monoisotopic mass
97.96901 Da
Formal charge
0
  • chloroethanes — is a (CHEBI:36016)
  • mutagen — has role (CHEBI:25435)
  • non-polar solvent — has role (CHEBI:48355)
  • hepatotoxic agent — has role (CHEBI:50908)
  • mutagen — has role (CHEBI:25435)
  • non-polar solvent — has role (CHEBI:48355)
  • hepatotoxic agent — has role (CHEBI:50908)
  • chloroethanes — is a (CHEBI:36016)
Additional curated names
1,2-dichloroethane1,2-DCE1,2-Dichloraethan1,2-Dichloroethane1,2-DICHLOROETHANEAethylenchloridAethylendichloridDCEDutch liquidEDCethane dichlorideethylene chlorideEthylene dichlorideGlycol dichloridealpha,beta-dichloroethane
Cross-references from this source
  • CAS: 107-06-2 — NIST Chemistry WebBook
  • CAS: 107-06-2 — KEGG COMPOUND
  • CAS: 107-06-2 — ChemIDplus
  • MANUAL_X_REF: 1,2-Dichloroethane — Wikipedia
  • MANUAL_X_REF: 12-DICHLOROETHANE — MetaCyc
  • MANUAL_X_REF: 2774 — PPDB
  • MANUAL_X_REF: c0001 — UM-BBD
  • MANUAL_X_REF: C06752 — KEGG COMPOUND
  • MANUAL_X_REF: DB03733 — DrugBank
  • MANUAL_X_REF: DCE — PDBeChem
  • MANUAL_X_REF: HMDB0029571 — HMDB
  • REGISTRY_NUMBER: 49272 — Gmelin
  • REGISTRY_NUMBER: 605264 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2021-06-17. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match11

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • ERG2024, Guide 131 (Ethylene dichloride): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H350: May cause cancer [Danger Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H304 (37.4%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (46.4%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H350 (100%): May cause cancer [Danger Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P331, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 666 reports by companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H350: May cause cancer [Danger Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P331, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Breathing or swallowing large amounts of 1,2-dichloroethane can produce nervous system disorders, kidney diseases, or lung effects. This can also lead to heart failure. Skin lesions and benign pulmonary tumors were reported in animals exposed dermally to liquid 1,2-dichloroethane. 1,2-dichloroethane can cause death from cardiac arrhythmia, bronchitis, hemorrhagic gastritis and colitis, hepatocellular damage, renal tubular necrosis and calcification, central nervous system depression, and histological changes in brain tissue after a sufficient single oral dose. (L156) Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: 1,2-Dichloroethane is a colorless, oily liquid. It is used in production of vinyl chloride, trichloroethylene, vinylidene chloride, and trichloroethane. It is also used as lead scavenger in antiknock gasoline, paint, varnish, and finish removers, metal degreasing, soaps and scouring compounds, wetting and penetrating agents, ore flotation, and as a solvent. HUMAN STUDIES: Acute incidental exposure to 1,2-dichloroethane by inhalation or ingestion has resulted in a variety of effects in humans, including effects on the central nervous system, liver, kidney, lung and cardiovascular system. The respiratory effects exhibited by individuals who died following acute oral exposure to 1,2-dichloroethane included congestion, pulmonary edema (at 570 mg/kg/day) and bronchitis. Ingestion of >/= 570 mg/kg/day of 1,2-dichloroethane resulted in severe hepatocellular damage and liver atrophy and necrosis. The potential carcinogenicity of 1,2-dichloroethane in exposed human populations has not been extensively investigated. It induced unscheduled DNA synthesis in primary cultures of human cells and gene mutation in several cell lines. Mutation frequency in human cell lines ha Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: 1,2-Dichloroethane is metabolized to 2-chloroacetaldehyde, S-(2-chloroethyl)glutathione by conjugation with glutathione, and to other putative reactive intermediates capable of binding covalently to cellular macromolecules in the liver, kidney, and other tissues. The conjugation of 1,2-dichloroethane with glutathione is catalyzed primarily by glutathione S-transferases. 1,2-Dichloroethane appears to be activated to mutagenic species to a lesser extent by the hepatic microsomal cytochrome P-450 enzyme system. Reactive metabolites of 1,2-dichloroethane produced by hepatic microsomal cytochrome P-450 can bind to cellular proteins and DNA. It has been suggested that 1,2-dichloroethane-induced toxicity occurs when the biotransformation processes are saturated, thereby allowing higher levels of 1,2-dichloroethane to circulate throughout the body and conjugate with glutathione instead of being detoxified and eliminated. (L156, A113) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: A BCF of 2 was measured for 1,2-dichloroethane in bluegill sunfish, Lepomis macrochirus(1). According to a classification scheme(2), this BCF suggests bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 33(2), indicates that 1,2-dichloroethane is expected to have very high mobility in soil(SRC). Volatilization of 1,2-dichloroethane from moist soil surfaces is expected(SRC) given a Henry's Law constant of 1.18X10-3 atm-cu m/mole(3). 1,2-Dichloroethane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 78.9 mm Hg at 25 °C(4). A 0% of Theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not expected in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 33(2), indicates that 1,2-dichloroethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.18X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 4 days, respectively(SRC). 1,2-Dichloroethane is not expected to undergo hydrolysis based on an approximated hydrolysis half-life of 50,000 years(5). According to a classification scheme(6), a reported BCF of 2(7), measured in fish, suggests the potential for bioconcentration in aquatic organisms is low. 1,2-Dichloroethane was 0% degraded after 21 days in the modified shake flask test(8), suggesting that biodegradation is not expected to be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-dichloroethane, which has a vapor pressure of 78.9 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-dichloroethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 65 days(SRC), calculated from its rate constant of 2.48X10-13 cu cm/molecule-sec at 25 °C(3). 1,2-Dichloroethane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). The tropospheric half-life of 1,2-dichloroethane in England has been reported as 17 weeks(5). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Ethylene dichloride is primarily used in the production of vinyl chloride as well as other chemicals. It is used in solvents in closed systems for various extraction and cleaning purposes in organic synthesis. It is also added to leaded gasoline as a lead scavenger. It was formerly used in ore flotation, as a grain fumigant, as a metal degreaser, and in textile and PVC cleaning. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used in organic synthesis; used in the past as a solvent, degreaser, paint remover, and fumigant; [ACGIH] Has been used as a dry cleaning agent and solvent for degreasing, resins, adhesives, cosmetics, and pharmaceuticals; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Restricted Notes: Use as fumigant suspended by EPA due to toxicity. [Sullivan, p. 1053] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For 1,2-dichloroethane (USEPA/OPP Pesticide Code: 042003) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The majority of the total EDC production is used for the production of vinyl chloride. Some EDC is used in the production of chlorinated solvents, such as 1,1,1-trichloroethane and tri- and tetrachloroethylene. The rest goes into various processes mainly for the synthesis of ethylenediamines. Its use as a solvent (dewaxing, deparaffinizing petroleum fractions, and coating remover) is marginal. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Manufacture of vinyl chloride, acetyl cellulose; solvent for fats, oils, waxes, gums, resins, and particularly for rubber. Has been used as an insect and soil fumigant. Organic solvent. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Fumigant /Former use/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 1,2-Dichloroethane (9 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The most common use of 1,2-dichloroethane is in the production of vinyl chloride which is used to make a variety of plastic and vinyl products including polyvinyl chloride (PVC) pipes, furniture and automobile upholstery, wall coverings, housewares, and automobile parts. It is also used as a solvent and is added to leaded gasoline to remove lead. Exposure occurs mainly by breathing air or drinking water contaminated with 1,2-dichloroethane. Humans can be exposed to low levels of 1,2-dichloroethane through the skin or air by contact with old products made with 1,2-dichloroethane. (L156) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1300-21-6
CAS 1300-21-6PubChem CID 6365

Verified chemistry for CAS 1300-21-6

1,1-Dichloroethane

IUPAC name
1,1-dichloroethane
Molecular formula
C2H4Cl2
Molecular weight
98.96 g/mol
Exact mass
97.9690055 Da
Monoisotopic mass
97.9690055 Da
XLogP3
1.9
Topological polar surface area
0.0 Ų
Molecular complexity
11.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Rotatable bonds
0
Heavy atoms
4
Covalent units
1

Names and synonyms reported to PubChem

75-34-3Ethylidene chlorideEthane, 1,1-dichloro-Ethylidene dichloride1,1-DichlorethaneDichloromethylmethaneAethylidenchlorid1,1-Dicloroetano
16 more reported names
1,1-DichloraethanCloruro di etilidene1,1-Dichloorethaan1,1-Ethylidene dichlorideRCRA waste number U076Chlorure D'ethylideneNCI-C04535Dichloroethane, 1,1-alpha,alpha-Dichloroethane0S989LNA44Asymmetrical dichloroethaneRefChem:71043HCC 150A200-863-5DICHLOROETHANE1,1-Dichloroethane-d4
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
0
3D rings
0
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
CC(Cl)Cl
InChI
InChI=1S/C2H4Cl2/c1-2(3)4/h2H,1H3
InChIKey
SCYULBFZEHDVBN-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match6365

Attributed physical-property, hazard, environmental and use annotations.

  • Substance: 1,1-Dichloroethane Source: NTP Technical Reports
  • NTP Technical Report: TR-066: Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity (CASRN 75-34-3) (1978 ) Source: NTP Technical Reports
  • Peer Review Date: 01/18/78 Source: NTP Technical Reports
  • Conclusion for Male Rat: No Evidence Source: NTP Technical Reports
  • Conclusion for Female Rat: Equivocal Evidence Source: NTP Technical Reports
  • Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
  • Conclusion for Female Mice: Equivocal Evidence Source: NTP Technical Reports
  • Summary: There were dose-related marginal increases in mammary adenocarcinomas and in hemangiosarcomas among female rats and there was a statistically significant increase in the incidence of endometrial stromal polyps among dosed female mice as compared to controls. These findings are indicative of the possible carcinogenic potential of the test compound. However, it must be recognized that under the conditions of this bioassay there was no conclusive evidence for the carcinogenicity of 1,1-dichloroethane in Osborne-Mendel rats or B6C3F1 mice. Source: NTP Technical Reports
  • Carcinogen Classification: No indication of carcinogenicity (not listed by IARC). (L135) Source: Toxin and Toxin Target Database (T3DB)
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • ERG2024, Guide 130 (1,1-Dichloroethane): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap flush promptly - If this chemical contacts the skin, promptly flush the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and flush the skin with water. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P319, P330, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (12%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P330, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 50 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H333: May be harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P317, P304+P340, P305+P351+P338, P308+P316, P319, P321, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: 1,1-dichloroethane can cause kidney disease after long-term, high-level exposure in the air. It is also known to cause liver damage, as well as central nervous system depression. 1,1-Dichloroethane can cause dermatitis on prolonged dermal exposure. (L403, T65) Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: 1,1-Dichloroethane is a colorless, oily liquid. It is used as a chemical intermediate in the production of vinyl chloride and of 1,1,1-trichloroethane. It is also a grain fumigant and has limited use as a solvent for plastics, oils, fats, paint, and varnishes. 1,1-Dichloroethane is used in the manufacture of high vacuum rubber and silicone grease. The chemical can also be used as a coupling agent in antiknock gasoline, for metal degreasing, organic synthesis, and ore floatation. It was formerly used as an anesthetic but it is of no importance in this field today. HUMAN STUDIES: Symptoms of exposure to this compound may include liver and kidney damage, skin and eye irritation, dermatitis, skin burns, unconsciousness, CNS depression, drowsiness, nausea, vomiting, faintness, irritation of the respiratory tract, salivation, sneezing, coughing, dizziness, lacrimation, reddening of the conjunctiva, cyanosis, and circulatory failure. ANIMAL STUDIES: No toxic effects were observed in rabbits dermally exposed to an upper limit dose of 2 mL 1,1-dichloroethane/kg bw for 24 hr during a 14-day observation period. In a study of acute toxicity to adult male rats, there was Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Dichloroethane is most commonly used in the production of vinyl chloride monomer (1,2-dichloroethane). HUMAN STUDIES: Laboratory investigations were carried out on 280 workers exposed to vinyl chloride and dichloroethane. Some hematological indices and liver function were examined. A case of vinyl chloride disease was reported in which the combined effect of vinyl chloride and dichloroethane was apparent. The acute and subacute toxicity of dichloroethane increased when it was administered under conditions of high temperature. ANIMAL STUDIES: There are no data available. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: The limited information available about 1,1-dichloroethane suggests that it may be nephrotoxic, fetotoxic, and possibly carcinogenic. 1,1-Dichloroethane has been observed to enhance cell transformation and results suggest that 1,1-dichloroethane or a metabolite can bind to cellular macromolecules such as DNA. It had been reported that 1,1-dichloroethane binds to nucleic acids and proteins in vivo and in vitro. This binding is also mediated by the liver cytochrome-P-450 system. Phenobarbital enhances the extent of covalent macromolecular binding. Hence, metabolites of 1,1-dichloroethane bind to the DNA, RNA, and tissue proteins. (L403) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 7 was calculated in fish for 1,1-dichloroethane(SRC), using a log Kow of 1.79(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). All of the chloroethanes have an elimination half-life of < 2 days as measured by whole body levels in exposed bluegills(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: Aquatic and Atmospheric Fate: Chloroethanes are expected to be present in industrial air and water emissions. They volatilize rapidly from surface water and persist in urban atmospheres. Hydrolysis and biodegradation are expected to be slow. /Chloroethanes/ Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), measured Koc values of 30(2) and 9.2(3) indicate that 1,1-dichloroethane is expected to have very high mobility in soil(SRC). Volatilization of 1,1-dichloroethane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 5.62X10-3 atm-cu m/mole(4). 1,1-Dichloroethane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 227 mm Hg at 25 °C(5). The half-life of 1,1-dichloroethane under sulfate-reducing conditions was approximately 115 days using well monitoring data from a landfill with a contamination history(6), indicating that biodegradation is a slow environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), measured Koc values of 30(2) and 9.2(3) indicate that 1,1-dichloroethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 5.62X10-3 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 3 hrs and 4 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 7(SRC), from its log Kow of 1.79(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The half-life of 1,1-dichloroethane under sulfate-reducing conditions was approximately 115 days using well monitoring data from a landfill with a contamination history(9), indicating that biodegradation is a slow environmental fate process in water(SRC). Hydrolysis is not expected to be an important environmental fate process(SRC) given a hydrolysis half-life of 61.3 years at 25 °C and pH 7(10). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,1-dichloroethane, which has a vapor pressure of 227 mm Hg at 25 °C(SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,1-dichloroethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 59 days(SRC), calculated from its rate constant of 2.74X10-13 cu cm/molecule-sec at 25 °C(3). 1,1-Dichloroethane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Ethylidene dichloride is primarily used as an intermediate in the manufacture of other chemicals such as vinyl chloride and 1,1,1-trichloroethane, and to manufacture high vacuum rubber. In the past, ethylidene dichloride was used as an anesthetic, but that use has been discontinued. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used as a chemical intermediate, grain fumigant, and solvent for plastics and oils; in the past, used as an anesthetic; [ACGIH] Used as a cleaning agent, in metal degreasing, rubber cementing, in fabric spreading, ore flotation, fire extinguishing, as an insecticide spray, extraction solvent, coupling agent in antiknock gasoline, paint, varnish, and finish remover, and to make high vacuum rubber; [HSDB] Used as a reagent and solvent for paint and varnishes; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Painting (Solvents) [Category: Paint]; Farming (Pesticides) [Category: Industry]; Metal Extraction and Refining [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Reagent and chemical intermediate. Solvent for paint, varnishes; degreaser. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1,1-Dichlorethane is used as a chemical intermediate and grain fumigant /SRP: former use/ and has limited use as a solvent for plastics, oils, and fats. It was formerly used as an anesthetic but it is of no importance in this field today. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used in the manufacture of high vacuum rubber and silicone grease. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: ... primarily used as a feedstock for the production of 1,1,1-trichloroethane. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 1,1-Dichloroethane (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Most commonly used in the production of vinyl chloride monomer /1,2-dichloroethane/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: ... an intermediate in the production of 1,1,1-trichloroethane. Other uses negligable. /1,1-dichloroethane/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1,1-Dichloroethane is used primarily to make 1,1,1-trichloroethane and a number of other chemicals. It is also used to dissolve other substances such as paint, varnish and finish removers, and to remove grease. Exposure may results from breathing air containing vapors of 1,1-dichloroethane, drinking contaminated water, and through eye and skin contact. (L403) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist prohibited entry 191
Source record ID
prohibited:191
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
490
records marked Prohibited
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Dichloroethanes” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist prohibited entry 191, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Dichloroethanes. Hotlist prohibited entry 191. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/191/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

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Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

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