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CAS 1 record

CAS 107-06-2

CAS 107-06-2 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 107-06-2
CAS 107-06-2PubChem CID 11

1,2-Dichloroethane

1,2-dichloroethane is a member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2. It has a role as a mutagen, a non-polar solvent and a hepatotoxic agent. — ChEBI

IUPAC name
1,2-dichloroethane
Molecular formula
C2H4Cl2
Molecular weight
98.96 g/mol
Exact mass
97.9690055 Da
XLogP3
1.5
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

Ethylene dichlorideEthylene chlorideGlycol dichlorideDutch liquidEthane, 1,2-dichloro-Ethane dichloridesym-DichloroethaneAethylenchlorid
16 more reported names
BrocideDichlor-Mulsion1,2-DichlorethaneDichloro-1,2-ethaneDichloremulsionalpha,beta-Dichloroethane1,2-BichloroethaneBorer solBichlorure D'ethyleneDi-chlor-mulsionFreon 150Destruxol borer-sol1,2-DCE1,2-Ethylene dichlorideEthyleendichlorideCloruro di ethene
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:27789

1,2-dichloroethane

A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.

Formula
C2H4Cl2
Average mass
98.960 g/mol
Monoisotopic mass
97.96901 Da
Formal charge
0
  • chloroethanes — is a (CHEBI:36016)
  • mutagen — has role (CHEBI:25435)
  • non-polar solvent — has role (CHEBI:48355)
  • hepatotoxic agent — has role (CHEBI:50908)
  • mutagen — has role (CHEBI:25435)
  • non-polar solvent — has role (CHEBI:48355)
  • hepatotoxic agent — has role (CHEBI:50908)
  • chloroethanes — is a (CHEBI:36016)
Additional curated names
1,2-dichloroethane1,2-DCE1,2-Dichloraethan1,2-Dichloroethane1,2-DICHLOROETHANEAethylenchloridAethylendichloridDCEDutch liquidEDCethane dichlorideethylene chlorideEthylene dichlorideGlycol dichloridealpha,beta-dichloroethane
Cross-references from this source
  • CAS: 107-06-2 — NIST Chemistry WebBook
  • CAS: 107-06-2 — KEGG COMPOUND
  • CAS: 107-06-2 — ChemIDplus
  • MANUAL_X_REF: 1,2-Dichloroethane — Wikipedia
  • MANUAL_X_REF: 12-DICHLOROETHANE — MetaCyc
  • MANUAL_X_REF: 2774 — PPDB
  • MANUAL_X_REF: c0001 — UM-BBD
  • MANUAL_X_REF: C06752 — KEGG COMPOUND
  • MANUAL_X_REF: DB03733 — DrugBank
  • MANUAL_X_REF: DCE — PDBeChem
  • MANUAL_X_REF: HMDB0029571 — HMDB
  • REGISTRY_NUMBER: 49272 — Gmelin
  • REGISTRY_NUMBER: 605264 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2021-06-17. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match11

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • ERG2024, Guide 131 (Ethylene dichloride): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H350: May cause cancer [Danger Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H304 (37.4%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (46.4%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H350 (100%): May cause cancer [Danger Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P331, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 666 reports by companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H350: May cause cancer [Danger Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P331, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Breathing or swallowing large amounts of 1,2-dichloroethane can produce nervous system disorders, kidney diseases, or lung effects. This can also lead to heart failure. Skin lesions and benign pulmonary tumors were reported in animals exposed dermally to liquid 1,2-dichloroethane. 1,2-dichloroethane can cause death from cardiac arrhythmia, bronchitis, hemorrhagic gastritis and colitis, hepatocellular damage, renal tubular necrosis and calcification, central nervous system depression, and histological changes in brain tissue after a sufficient single oral dose. (L156) Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: 1,2-Dichloroethane is a colorless, oily liquid. It is used in production of vinyl chloride, trichloroethylene, vinylidene chloride, and trichloroethane. It is also used as lead scavenger in antiknock gasoline, paint, varnish, and finish removers, metal degreasing, soaps and scouring compounds, wetting and penetrating agents, ore flotation, and as a solvent. HUMAN STUDIES: Acute incidental exposure to 1,2-dichloroethane by inhalation or ingestion has resulted in a variety of effects in humans, including effects on the central nervous system, liver, kidney, lung and cardiovascular system. The respiratory effects exhibited by individuals who died following acute oral exposure to 1,2-dichloroethane included congestion, pulmonary edema (at 570 mg/kg/day) and bronchitis. Ingestion of >/= 570 mg/kg/day of 1,2-dichloroethane resulted in severe hepatocellular damage and liver atrophy and necrosis. The potential carcinogenicity of 1,2-dichloroethane in exposed human populations has not been extensively investigated. It induced unscheduled DNA synthesis in primary cultures of human cells and gene mutation in several cell lines. Mutation frequency in human cell lines ha Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: 1,2-Dichloroethane is metabolized to 2-chloroacetaldehyde, S-(2-chloroethyl)glutathione by conjugation with glutathione, and to other putative reactive intermediates capable of binding covalently to cellular macromolecules in the liver, kidney, and other tissues. The conjugation of 1,2-dichloroethane with glutathione is catalyzed primarily by glutathione S-transferases. 1,2-Dichloroethane appears to be activated to mutagenic species to a lesser extent by the hepatic microsomal cytochrome P-450 enzyme system. Reactive metabolites of 1,2-dichloroethane produced by hepatic microsomal cytochrome P-450 can bind to cellular proteins and DNA. It has been suggested that 1,2-dichloroethane-induced toxicity occurs when the biotransformation processes are saturated, thereby allowing higher levels of 1,2-dichloroethane to circulate throughout the body and conjugate with glutathione instead of being detoxified and eliminated. (L156, A113) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: A BCF of 2 was measured for 1,2-dichloroethane in bluegill sunfish, Lepomis macrochirus(1). According to a classification scheme(2), this BCF suggests bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 33(2), indicates that 1,2-dichloroethane is expected to have very high mobility in soil(SRC). Volatilization of 1,2-dichloroethane from moist soil surfaces is expected(SRC) given a Henry's Law constant of 1.18X10-3 atm-cu m/mole(3). 1,2-Dichloroethane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 78.9 mm Hg at 25 °C(4). A 0% of Theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not expected in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 33(2), indicates that 1,2-dichloroethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.18X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 4 days, respectively(SRC). 1,2-Dichloroethane is not expected to undergo hydrolysis based on an approximated hydrolysis half-life of 50,000 years(5). According to a classification scheme(6), a reported BCF of 2(7), measured in fish, suggests the potential for bioconcentration in aquatic organisms is low. 1,2-Dichloroethane was 0% degraded after 21 days in the modified shake flask test(8), suggesting that biodegradation is not expected to be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-dichloroethane, which has a vapor pressure of 78.9 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-dichloroethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 65 days(SRC), calculated from its rate constant of 2.48X10-13 cu cm/molecule-sec at 25 °C(3). 1,2-Dichloroethane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). The tropospheric half-life of 1,2-dichloroethane in England has been reported as 17 weeks(5). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Ethylene dichloride is primarily used in the production of vinyl chloride as well as other chemicals. It is used in solvents in closed systems for various extraction and cleaning purposes in organic synthesis. It is also added to leaded gasoline as a lead scavenger. It was formerly used in ore flotation, as a grain fumigant, as a metal degreaser, and in textile and PVC cleaning. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used in organic synthesis; used in the past as a solvent, degreaser, paint remover, and fumigant; [ACGIH] Has been used as a dry cleaning agent and solvent for degreasing, resins, adhesives, cosmetics, and pharmaceuticals; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Restricted Notes: Use as fumigant suspended by EPA due to toxicity. [Sullivan, p. 1053] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For 1,2-dichloroethane (USEPA/OPP Pesticide Code: 042003) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The majority of the total EDC production is used for the production of vinyl chloride. Some EDC is used in the production of chlorinated solvents, such as 1,1,1-trichloroethane and tri- and tetrachloroethylene. The rest goes into various processes mainly for the synthesis of ethylenediamines. Its use as a solvent (dewaxing, deparaffinizing petroleum fractions, and coating remover) is marginal. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Manufacture of vinyl chloride, acetyl cellulose; solvent for fats, oils, waxes, gums, resins, and particularly for rubber. Has been used as an insect and soil fumigant. Organic solvent. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Fumigant /Former use/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 1,2-Dichloroethane (9 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The most common use of 1,2-dichloroethane is in the production of vinyl chloride which is used to make a variety of plastic and vinyl products including polyvinyl chloride (PVC) pipes, furniture and automobile upholstery, wall coverings, housewares, and automobile parts. It is also used as a solvent and is added to leaded gasoline to remove lead. Exposure occurs mainly by breathing air or drinking water contaminated with 1,2-dichloroethane. Humans can be exposed to low levels of 1,2-dichloroethane through the skin or air by contact with old products made with 1,2-dichloroethane. (L156) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 107-06-2

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CAS 107-06-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

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