Dichloroethanes (ethylene chlorides) e.g. 1,2-dichloroethane
New Zealand Cosmetic Products Group Standard Schedule 4, reference 125.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- New Zealand Cosmetic Products Group Standard Schedule 4, reference 125.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- Dichloroethanes (ethylene chlorides) e.g. 1,2-dichloroethane
- CAS
- 107-06-2
- EC
- Not supplied in this source row
- Identity mapping
- Exact CAS: 107-06-2
- Linked ingredient
- ETHYLENE DICHLORIDE
Linked CosIng identity data
Names and aliases
EU inventory restriction note: II/125
Recorded cosmetic function: NOT REPORTED
Function pages:NOT REPORTED
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
1 linked record
Open supporting recordCanada
1 linked record · 1 with specific conditions
Open supporting recordNew Zealand
Current record1 linked record
Open supporting recordASEAN
1 linked record
Open supporting recordChina
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 107-06-2
1,2-Dichloroethane
1,2-dichloroethane is a member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2. It has a role as a mutagen, a non-polar solvent and a hepatotoxic agent. — ChEBI
- IUPAC name
- 1,2-dichloroethane
- Molecular formula
- C2H4Cl2
- Molecular weight
- 98.96 g/mol
- Exact mass
- 97.9690055 Da
- Monoisotopic mass
- 97.9690055 Da
- XLogP3
- 1.5
- Topological polar surface area
- 0.0 Ų
- Molecular complexity
- 6.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 0
- Rotatable bonds
- 1
- Heavy atoms
- 4
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:27789
- ChEMBL:CHEMBL16370
- EPA DTXSID:DTXSID6020438
- PubMed:37150348
- PubMed:37028497
- PubMed:34560092
- PubMed:31734271
- PubMed:31520740
- PubMed:30664321
- PubMed:30081051
- PubMed:28973639
- PubMed:28960355
- PubMed:28421967
- PubMed:28189721
- PubMed:27301210
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 0
- 3D rings
- 0
- 3D hydrophobes
- 0
- 3D acceptor features
- 0
- 3D donor features
- 0
- 3D anionic centres
- 0
- 3D cationic centres
- 0
- 3D conformers
- 3
- Effective 3D rotors
- 1.0
Machine-readable structure identifiers
- SMILES
C(CCl)Cl- InChI
InChI=1S/C2H4Cl2/c3-1-2-4/h1-2H2- InChIKey
WSLDOOZREJYCGB-UHFFFAOYSA-N
Evidence from additional scientific databases
EMBL-EBI ChEBI
1,2-dichloroethane
A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.
- Formula
- C2H4Cl2
- Average mass
- 98.960 g/mol
- Monoisotopic mass
- 97.96901 Da
- Formal charge
- 0
- chloroethanes — is a (CHEBI:36016)
- mutagen — has role (CHEBI:25435)
- non-polar solvent — has role (CHEBI:48355)
- hepatotoxic agent — has role (CHEBI:50908)
- mutagen — has role (CHEBI:25435)
- non-polar solvent — has role (CHEBI:48355)
- hepatotoxic agent — has role (CHEBI:50908)
- chloroethanes — is a (CHEBI:36016)
Additional curated names
Cross-references from this source
- CAS: 107-06-2 — NIST Chemistry WebBook
- CAS: 107-06-2 — KEGG COMPOUND
- CAS: 107-06-2 — ChemIDplus
- MANUAL_X_REF: 1,2-Dichloroethane — Wikipedia
- MANUAL_X_REF: 12-DICHLOROETHANE — MetaCyc
- MANUAL_X_REF: 2774 — PPDB
- MANUAL_X_REF: c0001 — UM-BBD
- MANUAL_X_REF: C06752 — KEGG COMPOUND
- MANUAL_X_REF: DB03733 — DrugBank
- MANUAL_X_REF: DCE — PDBeChem
- MANUAL_X_REF: HMDB0029571 — HMDB
- REGISTRY_NUMBER: 49272 — Gmelin
- REGISTRY_NUMBER: 605264 — Reaxys
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2021-06-17. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 775 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 775 °F (413 °C) Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 440 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 182.3 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 83.5 °C Source: DrugBank
- Boiling Point: 83.4 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 83.00 to 84.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 83.5 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 182 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 83.5 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 182 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: Heavy liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Clear, colorless, oily liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Clear liquid at ambient temperatures Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless liquid [Note: Decomposes slowly, becomes acidic & darkens in color] Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless, oily liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.253 at 68 °F (USCG, 1999) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 1.2454 at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 1.2 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 1.24 Source: Occupational Safety and Health Administration (OSHA)
- Density: 1.2454 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 1.24 Source: The National Institute for Occupational Safety and Health (NIOSH)
- Flash Point: 56 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 13.0 °C (55.4 °F) - closed cup - Tested according to Annex V of Directive 67/548/EEC. Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 56 °F (13 °C) - closed cup Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 65 °F (18 °C) - open cup. Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 13 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 56 °F Source: Occupational Safety and Health Administration (OSHA)
- Flash Point: 56 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- LogP: 1.48 Source: DrugBank
- LogP: log Kow = 1.48 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 1.48 Source: Human Metabolome Database (HMDB)
- LogP: 1.48 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -31.5 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: -35.5 °C Source: DrugBank
- Melting Point: -35.6 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -35.3 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -35.7 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -32 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: -35.7 °C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: -32 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: Pleasant, chloroform-like Source: Hazardous Substances Data Bank (HSDB)
- Odor: Pleasant odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Chloroform-like odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Sweet Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Ethylene dichloride appears as a clear colorless liquid with a chloroform-like odor. Flash point 56 °F. Denser than water and insoluble in water. Vapors are heavier than air. Density 10.4 lb / gal. Source: CAMEO Chemicals
- Physical Description: Liquid; Gas Vapor Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid with a pleasant, chloroform-like odor. [Note: Decomposes slowly, becomes acidic & darkens in color.] [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS VISCOUS LIQUID WITH CHARACTERISTIC ODOUR. TURNS DARK ON EXPOSURE TO AIR, MOISTURE AND LIGHT. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Colorless liquid with a pleasant, chloroform-like odor. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Colorless liquid with a pleasant, chloroform-like odor. [Note: Decomposes slowly, becomes acidic & darkens in color.] Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: Index of refraction: 1.4422 at 25 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 5 to 10 mg/mL at 66 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: 8600 mg/L (at 25 °C) Source: DrugBank
- Solubility: In water, 8,600 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in water at 20 °C: 0.86% wt Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 0.869 g/100 mL water at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible with alcohol, chloroform, ether Source: Hazardous Substances Data Bank (HSDB)
- Solubility: For more Solubility (Complete) data for 1,2-Dichloroethane (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 8.6 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water, g/100ml: 0.87 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: 0.9% Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 60 mmHg at 68 °F ; 100 mmHg at 84.9 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 78.9 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 78.9 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 8.7 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 64 mmHg Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 75 [mm Hg] @23.7 °C Source: PAC Chemical Database, U.S. Department of Energy
- Vapor Pressure: 64 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)
- Viscosity: 0.84 cP at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- IARC Carcinogenic Agent: 1,2-Dichloroethane Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 2B: Possibly carcinogenic to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 20: (1979) Some Halogenated Hydrocarbons; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print); Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3) Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1999 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1998 Source: International Agency for Research on Cancer (IARC)
- Substance: 1,2-Dichloroethane Source: NTP Technical Reports
- NTP Technical Report: TR-055: Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CASRN 107-06-2) (1978 ) Source: NTP Technical Reports
- Peer Review Date: 03/06/78 Source: NTP Technical Reports
- Conclusion for Male Rat: Clear Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: Clear Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: Clear Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: Clear Evidence Source: NTP Technical Reports
- Exposure Routes: The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, ingestion, skin absorption, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- Exposure Routes: Oral (L157); inhalation (L157) ; dermal (L157) Source: Toxin and Toxin Target Database (T3DB)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
- ERG2024, Guide 131 (Ethylene dichloride): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H350: May cause cancer [Danger Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H304 (37.4%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (46.4%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H350 (100%): May cause cancer [Danger Carcinogenicity] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P331, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 666 reports by companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H350: May cause cancer [Danger Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P331, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Health Effects: Breathing or swallowing large amounts of 1,2-dichloroethane can produce nervous system disorders, kidney diseases, or lung effects. This can also lead to heart failure. Skin lesions and benign pulmonary tumors were reported in animals exposed dermally to liquid 1,2-dichloroethane. 1,2-dichloroethane can cause death from cardiac arrhythmia, bronchitis, hemorrhagic gastritis and colitis, hepatocellular damage, renal tubular necrosis and calcification, central nervous system depression, and histological changes in brain tissue after a sufficient single oral dose. (L156) Source: Toxin and Toxin Target Database (T3DB)
- NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Cancer, Developmental (effects while organs are developing), Gastrointestinal (Stomach and Intestines, part of the digestive system), Hepatic (Liver), Immunological (Immune System), Neurological (Nervous System), Ocular (Eyes), Renal (Urinary System or Kidneys), Reproductive (Producing Children) Source: Agency for Toxic Substances and Disease Registry (ATSDR)
- Target Organs: Eyes, skin, kidneys, liver, central nervous system, cardiovascular system Source: The National Institute for Occupational Safety and Health (NIOSH)
- Toxicity Summary: IDENTIFICATION AND USE: 1,2-Dichloroethane is a colorless, oily liquid. It is used in production of vinyl chloride, trichloroethylene, vinylidene chloride, and trichloroethane. It is also used as lead scavenger in antiknock gasoline, paint, varnish, and finish removers, metal degreasing, soaps and scouring compounds, wetting and penetrating agents, ore flotation, and as a solvent. HUMAN STUDIES: Acute incidental exposure to 1,2-dichloroethane by inhalation or ingestion has resulted in a variety of effects in humans, including effects on the central nervous system, liver, kidney, lung and cardiovascular system. The respiratory effects exhibited by individuals who died following acute oral exposure to 1,2-dichloroethane included congestion, pulmonary edema (at 570 mg/kg/day) and bronchitis. Ingestion of >/= 570 mg/kg/day of 1,2-dichloroethane resulted in severe hepatocellular damage and liver atrophy and necrosis. The potential carcinogenicity of 1,2-dichloroethane in exposed human populations has not been extensively investigated. It induced unscheduled DNA synthesis in primary cultures of human cells and gene mutation in several cell lines. Mutation frequency in human cell lines ha Source: Hazardous Substances Data Bank (HSDB)
- Toxicity Summary: 1,2-Dichloroethane is metabolized to 2-chloroacetaldehyde, S-(2-chloroethyl)glutathione by conjugation with glutathione, and to other putative reactive intermediates capable of binding covalently to cellular macromolecules in the liver, kidney, and other tissues. The conjugation of 1,2-dichloroethane with glutathione is catalyzed primarily by glutathione S-transferases. 1,2-Dichloroethane appears to be activated to mutagenic species to a lesser extent by the hepatic microsomal cytochrome P-450 enzyme system. Reactive metabolites of 1,2-dichloroethane produced by hepatic microsomal cytochrome P-450 can bind to cellular proteins and DNA. It has been suggested that 1,2-dichloroethane-induced toxicity occurs when the biotransformation processes are saturated, thereby allowing higher levels of 1,2-dichloroethane to circulate throughout the body and conjugate with glutathione instead of being detoxified and eliminated. (L156, A113) Source: Toxin and Toxin Target Database (T3DB)
- Environmental Bioconcentration: A BCF of 2 was measured for 1,2-dichloroethane in bluegill sunfish, Lepomis macrochirus(1). According to a classification scheme(2), this BCF suggests bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 33(2), indicates that 1,2-dichloroethane is expected to have very high mobility in soil(SRC). Volatilization of 1,2-dichloroethane from moist soil surfaces is expected(SRC) given a Henry's Law constant of 1.18X10-3 atm-cu m/mole(3). 1,2-Dichloroethane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 78.9 mm Hg at 25 °C(4). A 0% of Theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not expected in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 33(2), indicates that 1,2-dichloroethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.18X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 4 days, respectively(SRC). 1,2-Dichloroethane is not expected to undergo hydrolysis based on an approximated hydrolysis half-life of 50,000 years(5). According to a classification scheme(6), a reported BCF of 2(7), measured in fish, suggests the potential for bioconcentration in aquatic organisms is low. 1,2-Dichloroethane was 0% degraded after 21 days in the modified shake flask test(8), suggesting that biodegradation is not expected to be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-dichloroethane, which has a vapor pressure of 78.9 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-dichloroethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 65 days(SRC), calculated from its rate constant of 2.48X10-13 cu cm/molecule-sec at 25 °C(3). 1,2-Dichloroethane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). The tropospheric half-life of 1,2-dichloroethane in England has been reported as 17 weeks(5). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Intermediate Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Monomers; Solvent; Intermediate; Soil amendments (fertilizers); Flame retardant Source: EPA Chemical Data Reporting (CDR)
- Uses: Ethylene dichloride is primarily used in the production of vinyl chloride as well as other chemicals. It is used in solvents in closed systems for various extraction and cleaning purposes in organic synthesis. It is also added to leaded gasoline as a lead scavenger. It was formerly used in ore flotation, as a grain fumigant, as a metal degreaser, and in textile and PVC cleaning. Source: EPA Hazardous Air Pollutants
- Sources/Uses: Used in organic synthesis; used in the past as a solvent, degreaser, paint remover, and fumigant; [ACGIH] Has been used as a dry cleaning agent and solvent for degreasing, resins, adhesives, cosmetics, and pharmaceuticals; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Restricted Notes: Use as fumigant suspended by EPA due to toxicity. [Sullivan, p. 1053] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: For 1,2-dichloroethane (USEPA/OPP Pesticide Code: 042003) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
- Uses: The majority of the total EDC production is used for the production of vinyl chloride. Some EDC is used in the production of chlorinated solvents, such as 1,1,1-trichloroethane and tri- and tetrachloroethylene. The rest goes into various processes mainly for the synthesis of ethylenediamines. Its use as a solvent (dewaxing, deparaffinizing petroleum fractions, and coating remover) is marginal. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Manufacture of vinyl chloride, acetyl cellulose; solvent for fats, oils, waxes, gums, resins, and particularly for rubber. Has been used as an insect and soil fumigant. Organic solvent. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Fumigant /Former use/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for 1,2-Dichloroethane (9 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
- Uses: The most common use of 1,2-dichloroethane is in the production of vinyl chloride which is used to make a variety of plastic and vinyl products including polyvinyl chloride (PVC) pipes, furniture and automobile upholstery, wall coverings, housewares, and automobile parts. It is also used as a solvent and is added to leaded gasoline to remove lead. Exposure occurs mainly by breathing air or drinking water contaminated with 1,2-dichloroethane. Humans can be exposed to low levels of 1,2-dichloroethane through the skin or air by contact with old products made with 1,2-dichloroethane. (L156) Source: Toxin and Toxin Target Database (T3DB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- New Zealand cosmetic product schedules 4–8
- Source reference
- Schedule 4, reference 125, source row 127
- Source record ID
S4-127- Source version
- effective-2026-01-01
- Source language
- English
- Translation status
- Original is English
- Effective date
- 2026-01-01
- Source updated
- 2024-01-01
- Snapshot checked
- 2026-08-30 04:54 UTC
- Validation method
- openpyxl extraction; reviewed per-schedule counts
- SHA-256
4e62e372fb0aad7ac630af8c41fa50b38b52a793fd51b99697a65f8ecce1ae8a
Registered dataset notes
- Dataset coverage
- Prohibited and restricted substances, permitted colorants, preservatives and UV filters
- Authority note
- Official EPA group standard schedules; current market-specific rule source
How this record fits the market dataset
Status distribution
Condition text is present on 747 of 2913 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
New Zealand market context
Complete schedules dataset
Coverage version: Cosmetic Products Group Standard schedules effective 1 January 2026
Schedules 4–8: prohibited, restricted, colourant, preservative and UV-filter entries.
Verification checklist
- Search exact identity across Schedules 4–8.
- Apply use, concentration and warning conditions.
- Check hazardous-substance classification and Group Standard scope.
- Confirm the latest legal instrument, not only the spreadsheet.
Official market sources
- New Zealand cosmetic product schedules 4–8Official EPA group standard schedules; current market-specific rule source
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Dichloroethanes (ethylene chlorides) e.g. 1,2-dichloroethane” and every CAS/EC identifier refer to the material in your supplier specification.
- Search exact identity across Schedules 4–8.
- Apply use, concentration and warning conditions.
- Check hazardous-substance classification and Group Standard scope.
- Confirm the latest legal instrument, not only the spreadsheet.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
Dichloroethanes (ethylene chlorides) e.g. 1,2-dichloroethane. Schedule 4, reference 125, source row 127. New Zealand. Source version effective-2026-01-01. CosIng Checker regulatory record: https://cosingchecker.com/regulations/nz/records/6810/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for New Zealand
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: effective-2026-01-01
- Effective date: 2026-01-01
What it does not prove
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source