BILIRUBIN
Bilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates that conforms to the formula
BILIRUBIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
Bilirubin
Bilirubin IXalpha is a member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin. It has a role as an antioxidant, a mouse metabolite and a human metabolite. It is a dicarboxylic acid and a member of biladienes. It contains a 24G7 epitope. It is a conjugate acid of a bilirubin(2-). — ChEBI
- IUPAC name
- 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
- Molecular formula
- C33H36N4O6
- Molecular weight
- 584.7 g/mol
- Exact mass
- 584.26348488 Da
- XLogP3
- 2.9
- Topological polar surface area
- 164.0 Ų
- Hydrogen-bond donors
- 6
- Hydrogen-bond acceptors
- 6
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:16990
- ChEMBL:CHEMBL501680
- EPA DTXSID:DTXSID8060905
- PubMed:38342443
- PubMed:37054934
- PubMed:34619301
- PubMed:34461081
- PubMed:33788065
- PubMed:32033040
- PubMed:30026087
- PubMed:29968805
- PubMed:29079291
- PubMed:28805483
- PubMed:27578021
- PubMed:27394961
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official European Commission record
- CosIng substance ID
- 104326
- Published in the Official Journal
- Yes
- Recorded by the Commission
- 2024-08-16
Fields as published by the European Commission. The link opens the entry itself, not a search for it.
Inventory details for BILIRUBIN
INCI name
BILIRUBIN
Description
Bilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates that conforms to the formula
Record provenance
- Inventory reference
- cosing-live-104326
- Imported identity
- BILIRUBIN
- Source update
- 2024-08-16
Annex records for BILIRUBIN
Key data
- ANTIOXIDANT
- Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
- CHELATING
- Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
- REDUCING
- Changing the chemical nature of another ingredient by adding hydrogen (or removing oxygen).
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How BILIRUBIN appears in the CosIng inventory
The CosIng inventory lists BILIRUBIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
BILIRUBIN is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for BILIRUBIN
This page reproduces the CosIng inventory entry for BILIRUBIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research BILIRUBIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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