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Official EU label nameGlossary entry 3414

BILIRUBIN

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

Resolved substance identity

CAS:635-65-4
EC:211-239-7
Ingredient index records:
BILIRUBIN
Cosmetic functions: ANTIOXIDANT; CHELATING; REDUCING

Bilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates that conforms to the formula

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1 matched or reported name
BILIRUBIN

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name BILIRUBIN.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 635-65-4
CAS 635-65-4PubChem CID 5280352

Bilirubin

Bilirubin IXalpha is a member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin. It has a role as an antioxidant, a mouse metabolite and a human metabolite. It is a dicarboxylic acid and a member of biladienes. It contains a 24G7 epitope. It is a conjugate acid of a bilirubin(2-). — ChEBI

IUPAC name
3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
Molecular formula
C33H36N4O6
Molecular weight
584.7 g/mol
Exact mass
584.26348488 Da
XLogP3
2.9
Topological polar surface area
164.0 Ų
Hydrogen-bond donors
6
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

HematoidinHemetoidinBilirubin IX-alphaCholerythrinBilirubin IXalphaBilirubin IX alpha2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acidBilirubin test
16 more reported names
RFM9X3LJ49NSC-2668521H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-CHEBI:169901,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic aciddelta BilirubinBilirubinate, CalciumCalcium Salt BilirubinDisodium Salt BilirubinSalt Bilirubin, CalciumMonosodium Salt BilirubinRefChem:568345211-239-7(4z,15z)-bilirubin ixalphaBilirubin IX.alpha.Disodium bilirubinate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortalUS EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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