What does the restriction note for AMMONIUM THIOGLYCOLATE mean?

The restriction field for AMMONIUM THIOGLYCOLATE reads: III/2a. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 5421-46-5?

CAS 5421-46-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains AMMONIUM THIOGLYCOLATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3190215/10/2010

AMMONIUM THIOGLYCOLATE

Ammonium mercaptoacetate

AMMONIUM THIOGLYCOLATE is linked to 1 EU annex record on this page. Inventory note: III/2a.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 5421-46-5

CAS 5421-46-5PubChem CID 21534

Ammonium Thioglycolate

Ammonium thioglycolate is an organic ammonium salt having thioglycolate(1) as the counterion. Also known as perm salt, it has use in perming hair. It has a role as an allergen and a reducing agent. It contains a thioglycolate(1-). — ChEBI

IUPAC name: azanium 2-sulfanylacetate

Molecular formula: C2H7NO2S
Molecular weight: 109.15 g/mol
Exact mass: 109.01974964 Da
Topological polar surface area: 42.1 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 2
Defined stereocentres: 0

Also known as

Ammonium mercaptoacetateThioglycolic acid ammonium saltThiofaco A-50Acetic acid, mercapto-, monoammonium saltAmmonium thioglycollateUSAF MO-2ammonium sulfanylacetateHSDB 7167

16 more reported names

Thioglycollic acid, ammonium saltNSC 6954UNII-6P9E788VZZEINECS 226-540-9Mercaptoacetic acid, monoammonium salt6P9E788VZZAI3-26246Acetic acid, 2-mercapto-, ammonium salt (1:1)CHEBI:156555EC 226-540-9NSC-6954AMMONIUM THIOGLYCOLATE [HSDB]Thiofaco A50Ammonium thiogylcollateRefChem:112211Thiogylcollic acid, ammonium salt

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:156555
EPA DTXSID:DTXSID2027599

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for AMMONIUM THIOGLYCOLATE

INCI name

AMMONIUM THIOGLYCOLATE

Description

Ammonium mercaptoacetate

Record provenance

Inventory reference: 31902
Imported identity: AMMONIUM THIOGLYCOLATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for AMMONIUM THIOGLYCOLATE

Annex III Restriction reference

Entry 2a

THIOGLYCOLIC ACID

CAS: 68-11-1

EC: 200-677-4

Key data

CAS

5421-46-5

226-540-9

Restriction

III/2a

Function

DEPILATORY: Breaking down the mechanical strength of hair fibers so that they can be removed by mild scraping/rubbing.
HAIR WAVING OR STRAIGHTENING: Modifying the chemical structure of the hair, allowing it to be set in the style required (permanent waves or hair straightening).
REDUCING: Changing the chemical nature of another ingredient by adding hydrogen (or removing oxygen).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#1835 · AMMONIUM THIOGLYCOLATE

Ingredients with overlapping formulation functions

AMMONIUM THIOLACTATEDEPILATORY, HAIR WAVING OR STRAIGHTENING, REDUCING

BACILLUS/LACTOBACILLUS/MONASCUS/RICE BRAN EXTRACT/SOYBEAN EXTRACT FERMENT FILTR…ANTIMICROBIAL, ANTIOXIDANT, DEPILATORY

BARIUM SULFIDEDEPILATORY

C4-6 OLEFIN/STYRENE COPOLYMERDEPILATORY, SKIN CONDITIONING

C5-6 OLEFIN/STYRENE COPOLYMERDEPILATORY, SKIN CONDITIONING

CALCIUM SULFIDEDEPILATORY

CALCIUM THIOGLYCOLATEDEPILATORY, KERATOLYTIC, REDUCING

CALCIUM THIOGLYCOLATE HYDROXIDEDEPILATORY

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How AMMONIUM THIOGLYCOLATE appears in the CosIng inventory

The CosIng inventory lists AMMONIUM THIOGLYCOLATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

AMMONIUM THIOGLYCOLATE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

AMMONIUM THIOGLYCOLATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for AMMONIUM THIOGLYCOLATE reads: "III/2a". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, AMMONIUM THIOGLYCOLATE carries the following function designation(s):

CAS 5421-46-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for AMMONIUM THIOGLYCOLATE

This page combines the CosIng inventory entry for AMMONIUM THIOGLYCOLATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research AMMONIUM THIOGLYCOLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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