What does the restriction note for CALCIUM THIOGLYCOLATE mean?

The restriction field for CALCIUM THIOGLYCOLATE reads: III/2a. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 814-71-1?

CAS 814-71-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CALCIUM THIOGLYCOLATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3235215/10/2010

CALCIUM THIOGLYCOLATE

Calcium bis(mercaptoacetate)

CALCIUM THIOGLYCOLATE is linked to 1 EU annex record on this page. Inventory note: III/2a.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 814-71-1

CAS 814-71-1PubChem CID 13141

Calcium Thioglycolate

Based on the available data, the CIR Expert Panel concluded that ... Calcium Thioglycolate is safe for use in hair straighteners, permanent waves, tonics, dressings, and so forth, wave sets, other non-coloring hair products, and hair dyes and colors, as described in this safety assessment, at concentrations up to 15.2% (as Thioglycolic Acid). Hairdressers should avoid skin contact and minimize consumer skin exposure. Calcium Thioglycolate in depilatories is safe when formulated to be non-irritating under conditions of recommended use. — Cosmetic Ingredient Review (CIR)

IUPAC name: calcium bis(2-sulfanylacetate)

Molecular formula: C4H6CaO4S2
Molecular weight: 222.3 g/mol
Exact mass: 221.9333419 Da
Topological polar surface area: 82.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 6
Covalent units: 3
Defined stereocentres: 0

Also known as

Acetic acid, mercapto-, calcium salt (2:1)EbacreamDepilCalcium thioglycollateCalcium mercaptoacetateJullyVikorCalcium bis(mercaptoacetate)

16 more reported names

Acetic acid, 2-mercapto-, calcium salt (2:1)Mercaptoacetic acid calcium derivativeRefChem:122917Secret Dig Hair Removal FoamSecret Dig hair removal spray foamSecret Dig Hair Removal Foam SpraySecret Dig hair removal spray. foam212-402-5249-881-5SurgexCalcium 2-mercaptoacetatecalcium;2-sulfanylacetateUNII-J96129652NEINECS 212-402-5HSDB 1962calcium bis(sulfanylacetate)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID6061151

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CALCIUM THIOGLYCOLATE

INCI name

CALCIUM THIOGLYCOLATE

Description

Calcium bis(mercaptoacetate)

Record provenance

Inventory reference: 32352
Imported identity: CALCIUM THIOGLYCOLATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CALCIUM THIOGLYCOLATE

Annex III Restriction reference

Entry 2a

THIOGLYCOLIC ACID

CAS: 68-11-1

EC: 200-677-4

Key data

CAS

814-71-1

212-402-5

Restriction

III/2a

Function

DEPILATORY: Breaking down the mechanical strength of hair fibers so that they can be removed by mild scraping/rubbing.
KERATOLYTIC: Helping to eliminate the dead cells of the stratum corneum.
REDUCING: Changing the chemical nature of another ingredient by adding hydrogen (or removing oxygen).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#4990 · CALCIUM THIOGLYCOLATE

Ingredients with overlapping formulation functions

AMMONIUM LACTATEBUFFERING, HUMECTANT, KERATOLYTIC, SKIN CONDITIONING

BETAINE SALICYLATEANTIMICROBIAL, KERATOLYTIC

BROMELAINKERATOLYTIC, SKIN CONDITIONING

CALCIUM LACTATEASTRINGENT, BUFFERING, KERATOLYTIC

CELLULASEKERATOLYTIC, ORAL CARE, VISCOSITY CONTROLLING

CHLOROACETIC ACIDKERATOLYTIC

MAGNESIUM LACTATEBUFFERING, KERATOLYTIC, SKIN CONDITIONING

PRUNUS CERASUS EXTRACTANTIOXIDANT, KERATOLYTIC, MOISTURISING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CALCIUM THIOGLYCOLATE appears in the CosIng inventory

The CosIng inventory lists CALCIUM THIOGLYCOLATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CALCIUM THIOGLYCOLATE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CALCIUM THIOGLYCOLATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for CALCIUM THIOGLYCOLATE reads: "III/2a". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, CALCIUM THIOGLYCOLATE carries the following function designation(s):

CAS 814-71-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CALCIUM THIOGLYCOLATE

This page combines the CosIng inventory entry for CALCIUM THIOGLYCOLATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research CALCIUM THIOGLYCOLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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