Is SYNEPHRINE HCL safe to use in EU cosmetics?

SYNEPHRINE HCL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 5985-28-4?

CAS 5985-28-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SYNEPHRINE HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9577119/04/2018

SYNEPHRINE HCL

Benzenemethanol, 4-hydroxy-\a-[(methylamino)methyl]-, hydrochloride (1:1)

SYNEPHRINE HCL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 5985-28-4

CAS 5985-28-4PubChem CID 42609626

Synephrine hydrochloride

IUPAC name: 4-[1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride

Molecular formula: C9H14ClNO2
Molecular weight: 203.66 g/mol
Exact mass: 203.0713064 Da
Topological polar surface area: 52.5 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 3
Covalent units: 2
Defined stereocentres: 0

Also known as

Synephrine HClOxedrine hydrochlorideoxedrine HClOcuton (TN)EN5D1IH09SUNII-EN5D1IH09SSYNEPHRINE HYDROCHLORIDE [MI]OXEDRINE HYDROCHLORIDE [MART.]

16 more reported names

OXEDRINE HYDROCHLORIDE [WHO-DD]EINECS 227-804-6p-Methylaminoaethanolphenol hydrochloridp-Methylaminoethanol phenol hydrochloridep-Methylaminoaethanolphenol hydrochlorid [German](RS)-1-(4-HYDROXYPHENYL)-2-(METHYLAMINO)ETHANOL HYDROCHLORIDEOXEDRINE HYDROCHLORIDE (MART.)l-1-p-Hydroxyphenyl-2-methylamino-1-ethanol hydrochloridep-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol hydrochlorideBenzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, hydrochlorideOcutonBENZYL ALCOHOL, p-HYDROXY-alpha-((METHYLAMINO)METHYL)-, HYDROCHLORIDERefChem:186992227-804-64-[1-hydroxy-2-(methylamino)ethyl]phenol hydrochloride4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID70975251
PubMed:1392

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SYNEPHRINE HCL

INCI name

SYNEPHRINE HCL

Description

Benzenemethanol, 4-hydroxy-\a-[(methylamino)methyl]-, hydrochloride (1:1)

Record provenance

Inventory reference: 95771
Imported identity: SYNEPHRINE HCL
Source update: 19/04/2018

European Commission CosIng source notes

Annex records for SYNEPHRINE HCL

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Key data

CAS

5985-28-4

227-804-6 (I)

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28157 · SYNEPHRINE HCl

Ingredients with overlapping formulation functions

SULFONATED CHITOSANANTIOXIDANT; ANTI-SEBUM; BLEACHING; BULKING; SKIN PROTECTING

SULINDACANTIOXIDANT

SUNFLOWER SEED OIL ETHYL FERULATE ESTERSANTIOXIDANT, BLEACHING, EMULSION STABILISING, SKIN CONDITIONING - EMOLLIENT, UV ABSORBER

SUPEROXIDE DISMUTASEANTIOXIDANT, REDUCING, SKIN CONDITIONING

SYRINGA OBLATA CALLUS EXTRACTANTIOXIDANT; SKIN CONDITIONING - EMOLLIENT

SYRINGA VULGARIS LEAF CELL EXTRACTANTIOXIDANT, SKIN PROTECTING

SYRINGA VULGARIS MERISTEM CELL CULTUREANTIOXIDANT, SKIN PROTECTING

SYRINGARESINOLANTIOXIDANT, BLEACHING, SKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SYNEPHRINE HCL appears in the CosIng inventory

The CosIng inventory lists SYNEPHRINE HCL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SYNEPHRINE HCL is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SYNEPHRINE HCL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SYNEPHRINE HCL carries the following function designation(s):

CAS 5985-28-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SYNEPHRINE HCL

This page reproduces the CosIng inventory entry for SYNEPHRINE HCL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SYNEPHRINE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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