Is SULINDAC safe to use in EU cosmetics?

SULINDAC is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 38194-50-2?

CAS 38194-50-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SULINDAC?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8639415/10/2010

SULINDAC

cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H- indene-3-acetic acid

SULINDAC is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 38194-50-2

CAS 38194-50-2PubChem CID 1548887

Sulindac

Sulindac is a commonly used nonsteroidal antiinflammatory drug (NSAID) that is available by prescription only and used predominantly to treat chronic arthritis. Sulindac is a rare, but well established cause of idiosyncratic, clinically apparent drug induced liver disease. — LiverTox

IUPAC name: 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid

Molecular formula: C20H17FO3S
Molecular weight: 356.4 g/mol
Exact mass: 356.08824374 Da
XLogP3: 3.4
Topological polar surface area: 73.6 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

ClinorilArthrocineArtribidSulindacoSulindacumCitireumaSulindac sulfoxideAflodac

16 more reported names

ImbaralMK-231AlgocetilClisundacReumofilSulinolSulreumaSudacMK 231cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acidcis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid184SNS8VUHNSC-757344CHEBI:93521H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:9352
ChEBI:CHEBI:93811
ChEMBL:CHEMBL15770
EPA DTXSID:DTXSID4023624
PubMed:32020584
PubMed:26894321
PubMed:22733274
PubMed:20541701

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SULINDAC

INCI name

SULINDAC

Description

cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H- indene-3-acetic acid

Record provenance

Inventory reference: 86394
Imported identity: SULINDAC
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for SULINDAC

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Key data

CAS

38194-50-2

253-819-2

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28080 · SULINDAC

Ingredients with overlapping formulation functions

STYRACH OBASSIS EXTRACTANTIOXIDANT, SKIN CONDITIONING

SUCCINOYL ASCORBATE PENTAPEPTIDE-6ANTIOXIDANT, BLEACHING, SKIN CONDITIONING, SKIN PROTECTING

SUCCINOYL METHYL KYNURENINEANTIOXIDANT; HUMECTANT; VISCOSITY CONTROLLING; SKIN CONDITIONING - MISCELLANEOUS; SURFACTANT - SOLU…

SULFONATED CHITOSANANTIOXIDANT; ANTI-SEBUM; BLEACHING; BULKING; SKIN PROTECTING

SUNFLOWER SEED OIL ETHYL FERULATE ESTERSANTIOXIDANT, BLEACHING, EMULSION STABILISING, SKIN CONDITIONING - EMOLLIENT, UV ABSORBER

SUPEROXIDE DISMUTASEANTIOXIDANT, REDUCING, SKIN CONDITIONING

SYNEPHRINE HCLANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

SYRINGA OBLATA CALLUS EXTRACTANTIOXIDANT; SKIN CONDITIONING - EMOLLIENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SULINDAC appears in the CosIng inventory

The CosIng inventory lists SULINDAC as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SULINDAC is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SULINDAC is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SULINDAC carries the following function designation(s):

ANTIOXIDANT

CAS 38194-50-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SULINDAC

This page reproduces the CosIng inventory entry for SULINDAC from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SULINDAC and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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