What function does SYRINGARESINOL serve in cosmetics?

According to the EU CosIng inventory, SYRINGARESINOL carries the following function designation(s): ANTIOXIDANT, BLEACHING, SKIN CONDITIONING, SKIN PROTECTING.

What other records share CAS 487-35-4?

CAS 487-35-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SYRINGARESINOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9707413/05/2019

SYRINGARESINOL

Phenol, 4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxy-

SYRINGARESINOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 487-35-4

CAS 487-35-4PubChem CID 100067

Syringaresinol

Syringaresinol is a lignan that is 7,9':7',9-diepoxylignane substituted by hydroxy groups at positions 4 and 4' and methoxy groups at positions 3, 3', 5 and 5' respectively. It has a role as a plant metabolite. It is a lignan, a polyphenol, an aromatic ether, a polyether and a furofuran. — ChEBI

IUPAC name: 4-[6-(4-hydroxy-3,5-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2,6-dimethoxyphenol

Molecular formula: C22H26O8
Molecular weight: 418.4 g/mol
Exact mass: 418.16276778 Da
XLogP3: 2.2
Topological polar surface area: 95.8 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 8
Covalent units: 1
Defined stereocentres: 0

Also known as

CHEBI:49211syringa-resinol4-(6-(4-hydroxy-3,5-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro(3,4-c)furan-3-yl)-2,6-dimethoxyphenolRefChem:9324631177-14-6Episyringaresinol4,4'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis(2,6-dimethoxyphenol)(+/-)-Syringaresinol;

16 more reported names

4,4'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxyphenol]Phenol,4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxy-Lirioresinol A4-[6-(4-hydroxy-3,5-dimethoxy-phenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2,6-dimethoxy-phenolSymplicosigenolSyringylresinolDL-Syringaresil4,4'-tetrahydro-1h,3h-furo[3,4-c]furan-1,4-diylbis(2,6-dimethoxyphenol)HY-N8307S(8-8)SDA-52609DA-78139FS-10194DS-012209CS-01429103,3,5,5-tetramethoxy-7,9,7,9-diepoxylignan-4,4-diol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:49211
ChEMBL:CHEMBL4469429
PubMed:23574627
PubMed:22980843
PubMed:22963516
PubMed:22876679
PubMed:22688032
PubMed:22646817
PubMed:22615643
PubMed:22368856
PubMed:22254011
PubMed:22170035
PubMed:22007546
PubMed:21954557

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SYRINGARESINOL

INCI name

SYRINGARESINOL

Description

Phenol, 4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxy-

Record provenance

Inventory reference: 97074
Imported identity: SYRINGARESINOL
Source update: 13/05/2019

European Commission CosIng source notes

Annex records for SYRINGARESINOL

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Key data

CAS

487-35-4

—

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
BLEACHING: Bleaching or lightening the shade of hair and/or skin.
SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28186 · SYRINGARESINOL

Ingredients with overlapping formulation functions

SUCCINOYL ASCORBATE PENTAPEPTIDE-6ANTIOXIDANT, BLEACHING, SKIN CONDITIONING, SKIN PROTECTING

SULFONATED CHITOSANANTIOXIDANT; ANTI-SEBUM; BLEACHING; BULKING; SKIN PROTECTING

SULFORAPHANEBLEACHING, SKIN PROTECTING

SUNFLOWER SEED OIL ETHYL FERULATE ESTERSANTIOXIDANT, BLEACHING, EMULSION STABILISING, SKIN CONDITIONING - EMOLLIENT, UV ABSORBER

SYZYGIUM FORMOSUM LEAF EXTRACTANTIMICROBIAL; ANTIOXIDANT; BLEACHING; SKIN PROTECTING

SYZYGIUM FORMOSUM LEAF WATERANTIOXIDANT; BLEACHING; SKIN PROTECTING

T-BUTYLPHENYL IMIDAZOLYLPHENYL SULFONAMIDEANTIOXIDANT, BLEACHING, SKIN PROTECTING

TAEDBLEACHING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SYRINGARESINOL appears in the CosIng inventory

The CosIng inventory lists SYRINGARESINOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SYRINGARESINOL is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SYRINGARESINOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SYRINGARESINOL carries the following function designation(s):

CAS 487-35-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SYRINGARESINOL

This page reproduces the CosIng inventory entry for SYRINGARESINOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SYRINGARESINOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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