SCOPARONE
6,7-Dimethoxycoumarin,6,7-Dimethylesculetin,2H-1-Benzopyran-2-one, 6,7-Dimethoxy-
SCOPARONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
Scoparone
Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as an antihypertensive agent, an antilipemic drug, an immunosuppressive agent, an anti-allergic agent, an anti-inflammatory agent and a plant metabolite. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin. — ChEBI
- IUPAC name
- 6,7-dimethoxychromen-2-one
- Molecular formula
- C11H10O4
- Molecular weight
- 206.19 g/mol
- Exact mass
- 206.05790880 Da
- XLogP3
- 1.9
- Topological polar surface area
- 44.8 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:9055
- ChEMBL:CHEMBL325864
- EPA DTXSID:DTXSID10152640
- PubMed:37449671
- PubMed:36542898
- PubMed:28299617
- PubMed:25315519
- PubMed:24685503
- PubMed:24333270
- PubMed:24176340
- PubMed:23535186
- PubMed:23086487
- PubMed:23017425
- PubMed:22870812
- PubMed:22654640
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Melting Point: 144 °C Source: Human Metabolome Database (HMDB)
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]; H319 (97.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P264+P265, P270, P280, P301+P316, P305+P351+P338, P321, P330, P337+P317, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for SCOPARONE
INCI name
SCOPARONE
Description
6,7-Dimethoxycoumarin,6,7-Dimethylesculetin,2H-1-Benzopyran-2-one, 6,7-Dimethoxy-
Record provenance
- Inventory reference
- 92012
- Imported identity
- SCOPARONE
- Source update
- 19/11/2014
Annex records for SCOPARONE
Key data
- ANTIOXIDANT
- Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How SCOPARONE appears in the CosIng inventory
The CosIng inventory lists SCOPARONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
SCOPARONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for SCOPARONE
This page reproduces the CosIng inventory entry for SCOPARONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research SCOPARONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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