Is PROTODIOSCIN safe to use in EU cosmetics?

PROTODIOSCIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 55056-80-9?

CAS 55056-80-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8324315/10/2010

PROTODIOSCIN

26-O-beta-D-Glycopyranosyl-22-hydroxyfurost-5-ene-3beta,26-diol-3-O-beta-diglucorhamnoside

PROTODIOSCIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 55056-80-9

CAS 55056-80-9PubChem CID 441891

Protodioscin

Protodioscin is a furostanol glycoside that consists of the trisaccharide alpha-L-Rha-(14)-[alpha-L-Rha-(12)]-beta-D-Glc attached to position 3 of 26-(beta-D-glucopyranosyloxy)-3beta,22-dihydroxyfurost-5-ene via a glycosidic linkage. Found in several plant species including yams, asparagus and funugreek. It has a role as an antineoplastic agent, an antilipemic drug, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a plant metabolite. It is a beta-D-glucoside, a pentacyclic triterpenoid, a cyclic hemiketal, a steroid saponin and a trisaccharide derivative. It derives from a hydride of a furostan. — ChEBI

IUPAC name: (2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[[(1S,2S,4S,6R,7S,8R,9S,12S,13R,16S)-6-hydroxy-7,9,13-trimethyl-6-[(3R)-3-methyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutyl]-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-en-16-yl]oxy]-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol

Molecular formula: C51H84O22
Molecular weight: 1049.2 g/mol
Exact mass: 1048.54542430 Da
XLogP3: -1.3
Topological polar surface area: 346.0 Å²
Hydrogen-bond donors: 13
Hydrogen-bond acceptors: 22
Covalent units: 1
Defined stereocentres: 31

Also known as

D0LC3PH24PCHEBI:8588(3beta,22R,25R)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl alpha-L-rhamnopyranosyl-(1->2)-[alpha-L-rhamnopyranosyl-(1->4)]-beta-D-glucopyranoside(3beta,22R,25R)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl alpha-L-rhamnopyranosyl-(1->2)-(alpha-L-rhamnopyranosyl-(1->4))-beta-D-glucopyranosideRefChem:46278Furostanol IProtodioscin?UNII-D0LC3PH24P

16 more reported names

PROTODIOSCINEFurostane base-2H + O-Hex, O-Hex-dHex-dHexproto-dioscinProtodioscin (Standard)PROTODIOSCIN [WHO-DD]HY-N0799REX-A3793Furost-5-ene-3,22,26-triol 3-chacotrioside-26-glucopyranosideHY-N0799CCG-270619CS-6050EBC-509148AS-75278P7057(3b, 25R)-26-(b-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl O-6-deoxy-a-L-mannopyranosyl-(1-2)-O-[6-deoxy-a-L-mannopyranosyl-(1- 4)]-b-D-glucopyranoside(3beta,22R,25R)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl alpha-L-rhamnopyranosyl-(1->2)-[alpha

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:8588
ChEMBL:CHEMBL4782480
PubMed:22738987
PubMed:22642742
PubMed:22579841
PubMed:22368416
PubMed:22367665
PubMed:22296876
PubMed:22066185
PubMed:22022002
PubMed:21886973
PubMed:21647317
PubMed:21535581
PubMed:21503618

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PROTODIOSCIN

INCI name

PROTODIOSCIN

Description

26-O-beta-D-Glycopyranosyl-22-hydroxyfurost-5-ene-3beta,26-diol-3-O-beta-diglucorhamnoside

Record provenance

Inventory reference: 83243
Imported identity: PROTODIOSCIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PROTODIOSCIN

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Key data

CAS

55056-80-9

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23379 · PROTODIOSCIN

Ingredients with overlapping formulation functions

PROTEA REPENS FLOWER NECTARSKIN CONDITIONING

PROTEASESKIN CONDITIONING

PROTEASE DEXTRANSKIN CONDITIONING

PROTOCATECHUICALDEHYDEANTIOXIDANT, BLEACHING, SKIN CONDITIONING

PRUNASINSKIN CONDITIONING

PRUNELLA VULGARISSKIN CONDITIONING

PRUNELLA VULGARIS FLOWER EXTRACTSKIN CONDITIONING

PRUNELLA VULGARIS LEAF EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PROTODIOSCIN appears in the CosIng inventory

The CosIng inventory lists PROTODIOSCIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PROTODIOSCIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PROTODIOSCIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PROTODIOSCIN carries the following function designation(s):

SKIN CONDITIONING

CAS 55056-80-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PROTODIOSCIN

This page reproduces the CosIng inventory entry for PROTODIOSCIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PROTODIOSCIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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