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CAS 139-85-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8355715/10/2010

PROTOCATECHUICALDEHYDE

3,4-Ddihydroxybenzaldehyde

PROTOCATECHUICALDEHYDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 139-85-5

CAS 139-85-5PubChem CID 8768

3,4-Dihydroxybenzaldehyde

3,4-dihydroxybenzaldehyde is a dihydroxybenzaldehyde. — ChEBI

IUPAC name: 3,4-dihydroxybenzaldehyde

Molecular formula: C7H6O3
Molecular weight: 138.12 g/mol
Exact mass: 138.031694049 Da
XLogP3: 1.3
Topological polar surface area: 57.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

ProtocatechualdehydePROTOCATECHUIC ALDEHYDERancinamycin IV4-Formyl-1,2-dihydroxybenzene3,4-Dihydroxybenzenecarbonal4PVP2HCH4TCHEBI:50205NSC-22961

16 more reported names

GM-W03RefChem:45419O HUI WHITE EXTREME CELLIGHT205-377-7Benzaldehyde, 3,4-dihydroxy-catechaldehyde3,4-dihydroxy-benzaldehyde4-Formyl-1,2-benzenediol1,2-Dihydroxy-4-formylbenzene3,4-dihydroxy benzaldehydeprotocatechuicaldehydeTadalafil Impurity 5UNII-4PVP2HCH4TNSC 229614,5-Dihydroxybenzaldehyde3,4-DHBAOP

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:50205
ChEMBL:CHEMBL222021
EPA DTXSID:DTXSID4074512
PubMed:40228705
PubMed:29732668
PubMed:29665407
PubMed:25582705
PubMed:24712725
PubMed:23159608
PubMed:23019903
PubMed:23019884
PubMed:22885041
PubMed:22861150
PubMed:22792795
PubMed:22779179

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PROTOCATECHUICALDEHYDE

INCI name

PROTOCATECHUICALDEHYDE

Description

3,4-Ddihydroxybenzaldehyde

Record provenance

Inventory reference: 83557
Imported identity: PROTOCATECHUICALDEHYDE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PROTOCATECHUICALDEHYDE

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Key data

CAS

139-85-5

205-377-7

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
BLEACHING: Bleaching or lightening the shade of hair and/or skin.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23378 · PROTOCATECHUICALDEHYDE

Ingredients with overlapping formulation functions

PIPERLONGUMINEANTIOXIDANT, BLEACHING, SKIN CONDITIONING

POLYGONUM FAGOPYRUM SPROUT EXTRACTANTIOXIDANT, ASTRINGENT, BLEACHING, SKIN CONDITIONING

POSIDONIA OCEANICA EXTRACTANTIOXIDANT, BLEACHING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

POTASSIUM METHOXYSALICYLATEBLEACHING

PRUNUS MUME BUD EXTRACTBLEACHING, HUMECTANT

PURPUROGALLIN CARBOXYLIC ACIDANTIOXIDANT; BLEACHING; SKIN CONDITIONING - MISCELLANEOUS

PYRUS MALUS ROOT BARK POWDERBLEACHING

QUINOYL TRIPEPTIDE-1ANTIOXIDANT, BLEACHING, HAIR CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PROTOCATECHUICALDEHYDE appears in the CosIng inventory

The CosIng inventory lists PROTOCATECHUICALDEHYDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PROTOCATECHUICALDEHYDE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PROTOCATECHUICALDEHYDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PROTOCATECHUICALDEHYDE carries the following function designation(s):

CAS 139-85-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PROTOCATECHUICALDEHYDE

This page reproduces the CosIng inventory entry for PROTOCATECHUICALDEHYDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PROTOCATECHUICALDEHYDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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