Is PROTEASE safe to use in EU cosmetics?

PROTEASE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 9001-92-7?

CAS 9001-92-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PROTEASE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3731615/10/2010

PROTEASE

Proteinase

PROTEASE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Exact external identity check

matched

One PubChem compound was retained because the exact CosIng name appears among its reported synonyms.

PubChem title: Bacillomycin
IUPAC name: 3-[(3R,6R,9S,16S,19R,22S,25S)-3,9-bis(2-amino-2-oxoethyl)-16-[(1R)-1-hydroxyethyl]-19-(hydroxymethyl)-6-[(4-hydroxyphenyl)methyl]-13-octyl-2,5,8,11,15,18,21,24-octaoxo-1,4,7,10,14,17,20,23-octazabicyclo[23.3.0]octacosan-22-yl]propanoic acid
Molecular formula: C45H68N10O15
Molecular weight: 989.1 g/mol
InChIKey: VLKSXJAPRDAENT-OWGHDAAGSA-N

Open exact PubChem record

Exact CosIng INCI name equals a PubChem synonym · Checked 2026-08-31

Inventory details for PROTEASE

INCI name

PROTEASE

Description

Proteinase

Record provenance

Inventory reference: 37316
Imported identity: PROTEASE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PROTEASE

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Key data

CAS

9001-92-7

232-642-4

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23372 · PROTEASE

Ingredients with overlapping formulation functions

PROSTANTHERA ROTUNDIFOLIA LEAF EXTRACTSKIN CONDITIONING

PROTAMINE SULFATESKIN CONDITIONING

PROTEA CYNAROIDES FLOWER EXTRACTSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

PROTEA REPENS FLOWER NECTARSKIN CONDITIONING

PROTEASE DEXTRANSKIN CONDITIONING

PROTOCATECHUICALDEHYDEANTIOXIDANT, BLEACHING, SKIN CONDITIONING

PROTODIOSCINSKIN CONDITIONING

PRUNASINSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PROTEASE appears in the CosIng inventory

The CosIng inventory lists PROTEASE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PROTEASE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PROTEASE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PROTEASE carries the following function designation(s):

SKIN CONDITIONING

CAS 9001-92-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for PROTEASE

This page reproduces the CosIng inventory entry for PROTEASE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PROTEASE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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