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InventoryRef 5681215/10/2010

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 7365-45-9
CAS 7365-45-9PubChem CID 23831

4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid is a HEPES that is ethanesulfonic acid in which one of the methyl hydrogens is replaced by a 4-(2-hydroxyethyl)piperazin-1-yl group. A Good's buffer substance, pKa = 7.55 at 20 C. It is an organosulfonic acid and a HEPES. It is a conjugate acid of a 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate. It is a tautomer of a 2-[4-(2-hydroxyethyl)piperazin-4-ium-1-yl]ethanesulfonate. — ChEBI

IUPAC name
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Molecular formula
C8H18N2O4S
Molecular weight
238.31 g/mol
Exact mass
238.09872823 Da
XLogP3
-4.0
Topological polar surface area
89.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

HEPES1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-HEPES solution4-(2-Hydroxyethyl)-1-piperazineethane sulfonic acidRWW266YE9ICHEBI:42334hydroxyethylpiperazine ethane sulfonic acidNSC-166663
16 more reported names
Monosodium Salt, HEPESSalt, HEPES MonosodiumN 2 Hydroxyethylpiperazine N' 2' ethanesulfonic AcidN-2-Hydroxyethylpiperazine-N'-2'-ethanesulfonic AcidRefChem:783545CHEBI:46756Hydroxyethyl Piperazine Ethanesulfonic Acid Solution230-907-92-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acidN-2-Hydroxyethylpiperazine-N'-ethanesulfonateN-2-Hydroxyethylpiperazine-N'-ethanesulfonic acidN-2-Hydroxyethylpiperazine-N-ethane sulfonic acidNSC 166663N-2-Hydroxyethylpiperazine N',2'-ethanesulfonic acid
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

INCI name

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

Description

4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

Record provenance

Inventory reference
56812
Imported identity
HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
7365-45-9
EC
230-907-9
Restriction
—
Function
BUFFERING
Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#13282 · HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

Ingredients with overlapping formulation functions

HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMESBUFFERING; HAIR CONDITIONING; EYELASH CONDITIONING; SKIN CONDITIONING - MISCELLANEOUS
HYDROBROMIC ACIDBUFFERING
HYDROCHLORIC ACIDBUFFERING
HYDROXYECTOINBUFFERING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
IMIDAZOLEBUFFERING
ISOBUTYRIC ACIDBUFFERING
ISOPROPANOLAMINEBUFFERING
ISOPROPYLAMINEBUFFERING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID appears in the CosIng inventory

The CosIng inventory lists HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID carries the following function designation(s):

CAS 7365-45-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

This page reproduces the CosIng inventory entry for HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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