What does the restriction note for HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES mean?

The restriction field for HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES reads: II/416. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What function does HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES serve in cosmetics?

According to the EU CosIng inventory, HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES carries the following function designation(s): BUFFERING, HAIR CONDITIONING, EYELASH CONDITIONING, SKIN CONDITIONING - MISCELLANEOUS.

How do I check if my formula contains HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1050692024-08-14

HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES

Human Dermal Fibroblast Stem Cell Exosomes are the vesicles secreted into the conditioned media by human dermal fibroblast derived stem cells.

HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet. Inventory note: II/416.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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What the official INCI name states

The official label identifies a biological source material and its stated preparation or plant part.

Identity type from wording: biological_material
Preparation or form: EXOSOMES
Stated biological parts: STEM, CELL

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

Official European Commission record

CosIng substance ID: 105069
Published in the Official Journal: Yes
Recorded by the Commission: 2024-08-14

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES

INCI name

HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES

Description

Human Dermal Fibroblast Stem Cell Exosomes are the vesicles secreted into the conditioned media by human dermal fibroblast derived stem cells.

Record provenance

Inventory reference: cosing-live-105069
Imported identity: HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES
Source update: 2024-08-14

European Commission CosIng source notes

Annex records for HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES

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Key data

CAS

—

The CosIng inventory records no CAS number for this ingredient. That is the absence of an identifier in the source, not a finding about the substance.

—

Restriction

II/416

Function

BUFFERING: Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.
HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
EYELASH CONDITIONING: Conditioning and enhancing the appearance of eyelashes. Improving the gloss or sheen of eyelashes, coating the eyelash hair to increase the appearance of its diameter and length, or helping with the separation of the eyelash hair.
SKIN CONDITIONING - MISCELLANEOUS: Enhancing the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#12225 · HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES

Ingredients with overlapping formulation functions

BUTYL PELARGONATEHAIR CONDITIONING; NAIL CONDITIONING; DISPERSING NON-SURFACTANT; EYELASH CONDITIONING; SKIN CONDITI…

FURANYL METHYLTHIO METHYLSULFANYLTRIAZOLEASTRINGENT; HAIR CONDITIONING; EYELASH CONDITIONING

HEXYL PELARGONATEHAIR CONDITIONING; NAIL CONDITIONING; DISPERSING NON-SURFACTANT; EYELASH CONDITIONING; SKIN CONDITI…

HUMAN CELL MEMBRANE LIPOPROTEINS/LIPIDSEYELASH CONDITIONING, HAIR CONDITIONING, SKIN PROTECTING

HUMAN MONONUCLEAR CELL INDUCED PLURIPOTENT CELL CULTURE CONDITIONED MEDIAHAIR CONDITIONING; EYELASH CONDITIONING; SKIN CONDITIONING - MISCELLANEOUS

ISOPROPYL DIMETHYLNORCARBOPROSTATEEYELASH CONDITIONING

MORPHOLINO OXOPHENYL BENZOXAZOLEHAIR CONDITIONING; EYELASH CONDITIONING

MORPHOLINO OXOPIPERIDINYL BENZOXAZOLEHAIR CONDITIONING; EYELASH CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES appears in the CosIng inventory

The CosIng inventory lists HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

The restriction field for HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES reads: "II/416". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES carries the following function designation(s):

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES

This page reproduces the CosIng inventory entry for HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HUMAN DERMAL FIBROBLAST STEM CELL EXOSOMES and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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