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Official EU label nameGlossary entry 13282

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

Resolved substance identity

CAS:7365-45-9
EC:230-907-9
Ingredient index records:
HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID
Cosmetic functions: BUFFERING

4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

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1 matched or reported name
HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 7365-45-9
CAS 7365-45-9PubChem CID 23831

4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid is a HEPES that is ethanesulfonic acid in which one of the methyl hydrogens is replaced by a 4-(2-hydroxyethyl)piperazin-1-yl group. A Good's buffer substance, pKa = 7.55 at 20 C. It is an organosulfonic acid and a HEPES. It is a conjugate acid of a 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate. It is a tautomer of a 2-[4-(2-hydroxyethyl)piperazin-4-ium-1-yl]ethanesulfonate. — ChEBI

IUPAC name
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Molecular formula
C8H18N2O4S
Molecular weight
238.31 g/mol
Exact mass
238.09872823 Da
XLogP3
-4.0
Topological polar surface area
89.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

HEPES1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-HEPES solution4-(2-Hydroxyethyl)-1-piperazineethane sulfonic acidRWW266YE9ICHEBI:42334hydroxyethylpiperazine ethane sulfonic acidNSC-166663
16 more reported names
Monosodium Salt, HEPESSalt, HEPES MonosodiumN 2 Hydroxyethylpiperazine N' 2' ethanesulfonic AcidN-2-Hydroxyethylpiperazine-N'-2'-ethanesulfonic AcidRefChem:783545CHEBI:46756Hydroxyethyl Piperazine Ethanesulfonic Acid Solution230-907-92-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acidN-2-Hydroxyethylpiperazine-N'-ethanesulfonateN-2-Hydroxyethylpiperazine-N'-ethanesulfonic acidN-2-Hydroxyethylpiperazine-N-ethane sulfonic acidNSC 166663N-2-Hydroxyethylpiperazine N',2'-ethanesulfonic acid
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortalUS EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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