2-Amino-5-nitrophenol
New Zealand Cosmetic Products Group Standard Schedule 4, reference 384.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- New Zealand Cosmetic Products Group Standard Schedule 4, reference 384.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- 2-Amino-5-nitrophenol
- CAS
- 121-88-0
- EC
- Not supplied in this source row
- Identity mapping
- cas_number
- Linked ingredient
- 2-AMINO-5-NITROPHENOL
Linked CosIng identity data
Names and aliases
CosIng description: 2-Amino-5-nitrophenol
EU inventory restriction note: II/384
Recorded cosmetic function: HAIR DYEING
Function pages:HAIR DYEING
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
1 linked record
Open supporting recordCanada
1 linked record
Open supporting recordNew Zealand
Current record1 linked record
Open supporting recordASEAN
1 linked record
Open supporting recordChina
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 121-88-0
2-Amino-5-Nitrophenol
2-Amino-5-nitrophenol is a member of 3-nitrophenols. — ChEBI
- IUPAC name
- 2-amino-5-nitrophenol
- Molecular formula
- C6H6N2O3
- Molecular weight
- 154.12 g/mol
- Exact mass
- 154.03784206 Da
- Monoisotopic mass
- 154.03784206 Da
- XLogP3
- 1.5
- Topological polar surface area
- 92.1 Ų
- Molecular complexity
- 156.0
- Formal charge
- 0
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 0
- Heavy atoms
- 11
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:82384
- ChEMBL:CHEMBL164989
- EPA DTXSID:DTXSID1020063
- PubMed:22952646
- PubMed:22091177
- PubMed:21110342
- PubMed:20086194
- PubMed:19581339
- PubMed:17950496
- PubMed:17598023
- PubMed:12498276
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 7
- 3D rings
- 1
- 3D hydrophobes
- 0
- 3D acceptor features
- 2
- 3D donor features
- 2
- 3D anionic centres
- 1
- 3D cationic centres
- 1
- 3D conformers
- 1
- Effective 3D rotors
- 1.0
Machine-readable structure identifiers
- SMILES
C1=CC(=C(C=C1[N+](=O)[O-])O)N- InChI
InChI=1S/C6H6N2O3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H,7H2- InChIKey
DOPJTDJKZNWLRB-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Olive-brown, brown to orange crystalline solid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Orange needles when recrystallized from water Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 388 to 396 °F (decomposes) (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 205.8 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 2-amino-5-nitrophenol appears as brown amorphous granules or powder. Melting point 198-202 °C. Source: CAMEO Chemicals
- Physical Description: Olive-brown, brown, or orange solid; [HSDB] Green crystalline solid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Slightly soluble in water Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in ethanol, acetone, and benzene Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in deuterated DSMO Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 0.0000352 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- IARC Carcinogenic Agent: 2-Amino-5-nitrophenol Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 57: (1993) Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1993 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1992 Source: International Agency for Research on Cancer (IARC)
- Substance: 2-Amino-5-Nitrophenol Source: NTP Technical Reports
- NTP Technical Report: TR-334: Toxicology and Carcinogenesis Studies of 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1988 ) Source: NTP Technical Reports
- Peer Review Date: 03/04/87 Source: NTP Technical Reports
- Conclusion for Male Rat: Some Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (95%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (> 99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (94.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351 (92.7%): Suspected of causing cancer [Warning Carcinogenicity]; H411 (97.5%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2175 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 2-amino-5-nitrophenol(SRC), using an estimated log Kow of 0.99(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 85(SRC), determined from a structure estimation method(2), indicates that 2-amino-5-nitrophenol is expected to have high mobility in soil(SRC). Volatilization of 2-amino-5-nitrophenol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.8X10-13 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 2-Amino-5-nitrophenol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.5X10-5 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2007). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 85(SRC), determined from a structure estimation method(2), indicates that 2-amino-5-nitrophenol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 7.8X10-13 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of 0.99(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions(3). Biodegradation data were not available(SRC, 2007). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-amino-5-nitrophenol, which has an estimated vapor pressure of 3.5X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2-amino-5-nitrophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 41 hours(SRC), calculated from its rate constant of 9.4X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 2-amino-5-nitrophenol may be removed from the air by wet or dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Cosmetic Ingredient Review Link: CIR ingredient: 2-Amino-5-Nitrophenol Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used in hair dyes and to make azo dyes; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Dressing Hair [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: 2-Amino-5-nitrophenol is used as an intermediate in the manufacture of several azo dyes, including CI Solvent Red 8, which is used for coloring synthetic resins, lacquers, inks and wood stains. It is also used as a dye in semi-permanent hair coloring products to produce red and gold-blond shades. It is used to a limited extent in permanent hair coloring products. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- New Zealand cosmetic product schedules 4–8
- Source reference
- Schedule 4, reference 384, source row 402
- Source record ID
S4-402- Source version
- effective-2026-01-01
- Source language
- English
- Translation status
- Original is English
- Effective date
- 2026-01-01
- Source updated
- 2024-01-01
- Snapshot checked
- 2026-08-30 04:54 UTC
- Validation method
- openpyxl extraction; reviewed per-schedule counts
- SHA-256
4e62e372fb0aad7ac630af8c41fa50b38b52a793fd51b99697a65f8ecce1ae8a
Registered dataset notes
- Dataset coverage
- Prohibited and restricted substances, permitted colorants, preservatives and UV filters
- Authority note
- Official EPA group standard schedules; current market-specific rule source
How this record fits the market dataset
Status distribution
Condition text is present on 747 of 2913 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
New Zealand market context
Complete schedules dataset
Coverage version: Cosmetic Products Group Standard schedules effective 1 January 2026
Schedules 4–8: prohibited, restricted, colourant, preservative and UV-filter entries.
Verification checklist
- Search exact identity across Schedules 4–8.
- Apply use, concentration and warning conditions.
- Check hazardous-substance classification and Group Standard scope.
- Confirm the latest legal instrument, not only the spreadsheet.
Official market sources
- New Zealand cosmetic product schedules 4–8Official EPA group standard schedules; current market-specific rule source
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “2-Amino-5-nitrophenol” and every CAS/EC identifier refer to the material in your supplier specification.
- Search exact identity across Schedules 4–8.
- Apply use, concentration and warning conditions.
- Check hazardous-substance classification and Group Standard scope.
- Confirm the latest legal instrument, not only the spreadsheet.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
2-Amino-5-nitrophenol. Schedule 4, reference 384, source row 402. New Zealand. Source version effective-2026-01-01. CosIng Checker regulatory record: https://cosingchecker.com/regulations/nz/records/7085/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for New Zealand
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: effective-2026-01-01
- Effective date: 2026-01-01
What it does not prove
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source