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CAS 60-27-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5417815/10/2010

1-METHYLHYDANTOIN-2-IMIDE

4H-Imidazol-4-one, 2-amino-1,5-Dihydro-1-Methyl-

1-METHYLHYDANTOIN-2-IMIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 60-27-5

CAS 60-27-5PubChem CID 588

creatinine

Creatinine is a lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine. It has a role as a diagnostic agent and a human metabolite. It is a lactam and an imidazolidinone. It is functionally related to a creatine. — ChEBI

IUPAC name: 2-amino-3-methyl-4H-imidazol-5-one

Molecular formula: C4H7N3O
Molecular weight: 113.12 g/mol
Exact mass: 113.058911855 Da
XLogP3: -1.8
Topological polar surface area: 58.7 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

2-Imino-1-methylimidazolidin-4-one1-Methylglycocyamidine1-Methylhydantoin-2-imideKreatininCreatinine,heatedKreatininum2-amino-1-methylimidazolin-4-one2-amino-1-methyl-1,5-dihydro-4H-imidazol-4-one

16 more reported names

4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-creatininaNSC-13123AYI8EX34EU2-Amino-1,5-dihydro-1-methyl-4H-imidazol-4-oneCHEBI:16737NSC-760435CREATININE (II)CREATININE [II]IMIDAZOLIDIN-4-ONE, 2-IMINO-1-METHYLCREATININE (USP-RS)CREATININE [USP-RS]RefChem:5708200-466-7Creatine anhydride2-Imino-N-methylhydantoin

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:16737
ChEMBL:CHEMBL65567
PubMed:36066211
PubMed:32045570
PubMed:29988851
PubMed:29968805
PubMed:28710020
PubMed:27469509
PubMed:27056296
PubMed:25301743
PubMed:24868163
PubMed:24709313
PubMed:24012798
PubMed:23125906

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 1-METHYLHYDANTOIN-2-IMIDE

INCI name

1-METHYLHYDANTOIN-2-IMIDE

Description

4H-Imidazol-4-one, 2-amino-1,5-Dihydro-1-Methyl-

Record provenance

Inventory reference: 54178
Imported identity: 1-METHYLHYDANTOIN-2-IMIDE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for 1-METHYLHYDANTOIN-2-IMIDE

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Key data

CAS

60-27-5

200-466-7

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#135 · 1-METHYLHYDANTOIN-2-IMIDE

Ingredients with overlapping formulation functions

(PAEONIA LACTIFLORA BARK/SAP)/PHELLODENDRON AMURENSE BARK/MENTHA ARVENSIS LEAF/…HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

(SH-PENTAPEPTIDE-10 6-AMINOCAPROOYL SH-PENTAPEPTIDE-11) SPHUMECTANT, SKIN CONDITIONING

1,2-BUTANEDIOLHUMECTANT, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING

1,2-HEXANEDIOLSKIN CONDITIONING, SOLVENT

1-NAPHTHALENEACETIC ACIDSKIN CONDITIONING

10-HYDROXYDECANOIC ACIDSKIN CONDITIONING

10-HYDROXYDECENOIC ACIDSKIN CONDITIONING

10-HYDROXYSTEARIC ACIDSKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 1-METHYLHYDANTOIN-2-IMIDE appears in the CosIng inventory

The CosIng inventory lists 1-METHYLHYDANTOIN-2-IMIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

1-METHYLHYDANTOIN-2-IMIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

1-METHYLHYDANTOIN-2-IMIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 1-METHYLHYDANTOIN-2-IMIDE carries the following function designation(s):

SKIN CONDITIONING

CAS 60-27-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 1-METHYLHYDANTOIN-2-IMIDE

This page reproduces the CosIng inventory entry for 1-METHYLHYDANTOIN-2-IMIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research 1-METHYLHYDANTOIN-2-IMIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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