InventoryRef 3866210/08/2020
TRICLOCARBAN
1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea
TRICLOCARBAN is linked to 2 EU annex records on this page. Inventory note: III/100 V/23.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
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| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Evidence linked Restricted entry found Open this evidence | 2 | English and EU languages |
| Great Britain | Evidence linked Restricted + Permitted list with conditions Open this evidence | 2 | English |
| Canada | Source mapped Official source mapped; ingredient rule not imported | 0 | English and French |
| New Zealand | Evidence linked Restricted + Permitted list with conditions Open this evidence | 2 | English |
| ASEAN | Evidence linked Restricted + Permitted list with conditions Open this evidence | 2 | English and national languages |
| China | Source mapped Official source mapped; ingredient rule not imported | 0 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Evidence linked Restricted Open this evidence | 1 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Source mapped Official source mapped; ingredient rule not imported | 0 | Portuguese with INCI crosswalks |
| India | Evidence linked Restricted Open this evidence | 1 | English and Hindi |
| Saudi Arabia | Evidence linked Restricted Open this evidence | 1 | Arabic and English |
Chemical identity and properties
CAS 101-20-2PubChem CID 7547
Triclocarban
Triclocarban is a member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively. It has a role as an antimicrobial agent, a xenobiotic, an antiseptic drug, a disinfectant and an environmental contaminant. It is a member of phenylureas, a dichlorobenzene and a member of monochlorobenzenes. It is functionally related to a 1,3-diphenylurea. — ChEBI
- IUPAC name
- 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
- Molecular formula
- C13H9Cl3N2O
- Molecular weight
- 315.6 g/mol
- Exact mass
- 313.978046 Da
- XLogP3
- 5.3
- Topological polar surface area
- 41.1 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 1
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
3,4,4'-TRICHLOROCARBANILIDECutisanProcuteneSolubacterCusiterGenofaceTrilocarbanUrea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-
16 more reported names
3,4,4'-TrichlorodiphenylureaTrichlocarbanTriclocarbanumN-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)ureaNSC-72005TCC Soap3,4,4'-trichloro carbanilide1-(3',4'-Dichlorophenyl)-3-(4'-chlorophenyl)ureaENT 26925TCC (soap bacteriostat)Carbanilide, 3,4,4'-trichloro-CP 78416N-(3,4-Dichlorophenyl)-N'-(4-chlorophenyl)ureaBGG1Y1ED0YEPA Pesticide Chemical Code 027901CHEBI:48347
External database identifiers
- ChEBI:CHEBI:48347
- ChEMBL:CHEMBL1076347
- EPA DTXSID:DTXSID4026214
- PubMed:38631510
- PubMed:37385329
- PubMed:35413382
- PubMed:35164063
- PubMed:32065294
- PubMed:31868902
- PubMed:31576746
- PubMed:30940137
- PubMed:30657620
- PubMed:30592132
- PubMed:27979590
- PubMed:26827900
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:48347
triclocarban
A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
- Formula
- C13H9Cl3N2O
- Average mass
- 315.587 g/mol
- Monoisotopic mass
- 313.97805 Da
- Formal charge
- 0
- phenylureas — is a (CHEBI:134043)
- dichlorobenzene — is a (CHEBI:23697)
- monochlorobenzenes — is a (CHEBI:83403)
- disinfectant — has role (CHEBI:48219)
- antiseptic drug — has role (CHEBI:48218)
- xenobiotic — has role (CHEBI:35703)
- antimicrobial agent — has role (CHEBI:33281)
- environmental contaminant — has role (CHEBI:78298)
- 1,3-diphenylurea — has functional parent (CHEBI:41320)
- disinfectant — has role (CHEBI:48219)
- antiseptic drug — has role (CHEBI:48218)
- xenobiotic — has role (CHEBI:35703)
- antimicrobial agent — has role (CHEBI:33281)
- environmental contaminant — has role (CHEBI:78298)
- phenylureas — is a (CHEBI:134043)
- dichlorobenzene — is a (CHEBI:23697)
- monochlorobenzenes — is a (CHEBI:83403)
Additional curated names
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea1-(3',4'-dichlorophenyl)-3-(4'-chlorophenyl)urea3,4,4'-trichloro carbanilide3,4,4'-trichlorocarbanilide3,4,4'-trichlorodiphenylureaN-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)ureaNSC-72005TCC
Cross-references from this source
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2018-12-13. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7547
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 250 °C at 97.8 kPa (733 mm Hg) Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Fine white plates Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Fine plates Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Fine, white to off-white powder Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.336 g/cu cm at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Dissociation Constants: pKa = 12.7 Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow = 4.342 at 25 °C, pH 8.1 Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 482 to 493 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 491.2- 493 Source: DrugBank
- Melting Point: 254.4 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: MP: 255.2-256 °C Source: Hazardous Substances Data Bank (HSDB)
- Odor: Slight, characteristic odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Triclocarban appears as fine white plates or white powder. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: White solid; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: less than 1 mg/mL at 79 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Insoluble Source: DrugBank
- Solubility: In water, 0.11 mg/L at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Practically insoluble in water Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 1 g dissolves in 25 mL acetone; 3 mL dimethyl formamide Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In methanol, 1.6 g/L at 35 °C Source: Hazardous Substances Data Bank (HSDB)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H400 (96.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 185 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
- GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Substances Data Bank (HSDB)
- Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
- Toxicity Summary: IDENTIFICATION AND USE: Triclocarban (TCC) is a solid. It has anti-microbial activity and is used globally in a wide range of personal cleansing products that include deodorant soaps, detergents, cleansing lotions, and wipes. In North America, TCC is used exclusively as an antimicrobial and preservative in bar and liquid soaps and body washes. HUMAN STUDIES: Studies in humans indicate no evidence of skin sensitization or severe irritation. Petrolatum (0.1mL) containing 0, 1, 3, 6, and 9% TCC was applied continuously for 21 days on ten males. Minimal skin irritation was observed with the 9% concentration. There was no evidence of skin sensitization in volunteers tested with TCC (1.5% and 10%). The potential impact of exposure to TCC on fetal abnormalities was studied in 39 pregnant women diagnosed with fetal or post-birth abnormalities. Significantly increased levels of TCC were detected in maternal sera from mothers with abnormal births. TCC was also studied for its endocrine-disrupting effects. TCC exerted estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and dow Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: BCF values for triclocarban in rice fish (Oryzias latipes), exposed for 28 days to 20 and 2.0 ug/L were 80 and 81, respectively(1). A log BCF of 2.86 (BCF = 724) was measured using medaka (Oryzias latipes) exposed to 20 ug/L of triclocarban for 24 hours(2). According to a classification scheme(3), these BCF values suggest bioconcentration in aquatic organisms is moderate to high(SRC). Triclocarban BAFs in algae of 1600 to 2700 from three locations downstream of a waste water treatment plant in Pecan Creek, TX(4). Triclocarban bioaccumulation peaked at day 5 of a 56 day study of worms (Lumbriculus variegatus) in soil containing 22.4 ug/g dry weight triclocarban(5). Body burdens of 25 and 133 ng/g wet wt, corresponding to a biota soil accumulation factor range of 0.22 to 0.7, were reported after 28 days in earthworm (Eisenia foetida) present in 2 soils (Ashkum heavy-textured silty clay loam; Chelsea light-textured fine sand). The soils were amended with municipal (Chicago, IL) biosolids containing an average triclocarban concentration of 9200 ng/g dry wt, resulting in an average trace level soil concentration of 9 ng/g dry wt(6). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 12,000(2) to 71,687(3) indicate that triclocarban is expected to be immobile in soil(SRC). Volatilization of triclocarban from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.5X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Triclocarban is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.6X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(5). Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is not an important environmental fate process in soil(SRC). However using a continuous flow activated sludge, 50-100% degradation was obtained in 12 weeks, following lag periods of up to two weeks(7). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Dewatered municipal biosolids (DMBs) were applied to a field at a rate of approximately 22 Mg dw/ha in October 2008. Pharmaceuticals and personal care products (PPCPs) were monitored in groundwater, tile drainage, soil, DMB aggregates incorporated into the soil post-land application, and in the grain of wheat grown on the field for a period of approximately 1 year following application. Over 80 PPCPs were analyzed in the source DMB. PPCPs selected for in-depth monitoring included ... triclocarban .... PPCPs in tile were observed twice, approximately 3 weeks and 2 months post-application. Of all PPCPs measured in tile drainage, only carbamazepine, ibuprofen, acetaminophen, triclosan, triclocarban, venlafaxine, and citalopram were detected (5-74 ng/L). PPCPs were not detected in groundwater >2 m depth below the soil surface, and concentrations above detection limits at 2 m depth were only observed once just after the first rain event post-application. In groundwater, all compounds found in tile, except carbamazepine, acetaminophen and citalopram, were detected (10-19 ng/L). PPCPs were detected in DMB aggregates incorporated in soil up to 1 year post-application, wit Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 12,000(2) to 71687(3) indicate that triclocarban is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 4.5X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). According to a classification scheme(6), BCF values of 80(7) to 724(8) suggest the potential for bioconcentration in aquatic organisms is moderate to high(SRC). Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks(7) indicating that biodegradation is not an important environmental fate process in water(SRC). However using a continuous flow activated sludge, 50-100% degradation was obtained in 12 weeks, following lag periods of up to two weeks(9). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triclocarban, which has an estimated vapor pressure of 3.6X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase triclocarban may be removed from the air by wet and dry deposition(SRC). Triclocarban contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Sources/Uses: Used as an antiseptic in cleaning products; [Merck Index] Used for skin and mucous membrane disinfection; [Reference #1] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Using Disinfectants or Biocides [Category: Clean] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: For 3,4,4'-trichlorocarbanilide (USEPA/OPP Pesticide Code: 027901) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
- Uses: Bacteriostat and antiseptic in soaps and other cleansing compositions. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Bacteriostat in ... plastics. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Triclocarban is an anti-microbial active ingredient used globally in a wide range of personal cleansing products that include deodorant soaps, detergents, cleansing lotions, and wipes. In North America, triclocarban is used exclusively as an antimicrobial and preservative in bar and liquid soaps and body washes. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Deodorant soaps contain an active ingredient such as 3,4,4'-trichlorocarbanilide (trichlocarban) to inhibit the growth of skin bacteria responsible for the formation of odor-causing substances from perspiration Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for TRICLOCARBAN
INCI name
TRICLOCARBAN
INN name
triclocarban
Description
1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea
Record provenance
- Inventory reference
- 38662
- Imported identity
- TRICLOCARBAN
- Source update
- 10/08/2020
Annex records for TRICLOCARBAN
Key data
CAS
EC
Restriction
III/100
V/23
Function
- ANTIMICROBIAL
- Preventing and/or slowing down microbial growth.
- DEODORANT
- Reducing and/or eliminating unpleasant odour. Contributing against the formation of malodour on body surfaces.
- PRESERVATIVE
- Exclusively or mainly intended to inhibit the development of micro-organisms in the cosmetic product. All authorised preservatives are substances in the positive list of Annex V to the Cosmetics Regulation 1223/2009.
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How TRICLOCARBAN appears in the CosIng inventory
The CosIng inventory lists TRICLOCARBAN as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
TRICLOCARBAN is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
TRICLOCARBAN appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.
The restriction field for TRICLOCARBAN reads: "III/100
V/23". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.
According to the EU CosIng inventory, TRICLOCARBAN carries the following function designation(s):
CAS 101-20-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for TRICLOCARBAN
This page combines the CosIng inventory entry for TRICLOCARBAN with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.
Use this inventory page to research TRICLOCARBAN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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