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1-(4-Chlorophenyl)- 3-(3,4- dichlorophenyl)urea (10) Triclocarban (CAS No. 101-20-2)

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

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Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.
Conditions and restrictions
Field of application/use: Rinse-off products 1.5 percent Purity criteria: | Other limitations/requirements: - 3,3’,4,4’ Tetrachloroazobenzene ≤ 1 ppm - 3,3’,4,4’ Tetrachloroazoxybenzene ≤ 1 ppm For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product.

Substance identity

Official source name
1-(4-Chlorophenyl)- 3-(3,4- dichlorophenyl)urea (10) Triclocarban (CAS No. 101-20-2)
CAS
101-20-2
EC
202-924-1
Identity mapping
cas_number
Linked ingredient
TRICLOCARBAN
Search this identity across the siteCAS 101-20-2EC 202-924-1

Linked CosIng identity data

Names and aliases

TRICLOCARBANtriclocarban

CosIng description: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

EU inventory restriction note: III/100 V/23

Recorded cosmetic function: ANTIMICROBIAL, DEODORANT, PRESERVATIVE

Function pages:ANTIMICROBIAL, DEODORANT, PRESERVATIVE

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

7 market datasets

Great Britain

Permitted list with conditionsRestricted

2 linked records · 2 with specific conditions

Open supporting record

New Zealand

Permitted list with conditionsRestricted

2 linked records · 2 with specific conditions

Open supporting record

ASEAN

Permitted list with conditionsRestricted

2 linked records · 2 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 101-20-2
CAS 101-20-2PubChem CID 7547

Verified chemistry for CAS 101-20-2

Triclocarban

Triclocarban is a member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively. It has a role as an antimicrobial agent, a xenobiotic, an antiseptic drug, a disinfectant and an environmental contaminant. It is a member of phenylureas, a dichlorobenzene and a member of monochlorobenzenes. It is functionally related to a 1,3-diphenylurea. — ChEBI

IUPAC name
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
Molecular formula
C13H9Cl3N2O
Molecular weight
315.6 g/mol
Exact mass
313.978046 Da
Monoisotopic mass
313.978046 Da
XLogP3
5.3
Topological polar surface area
41.1 Ų
Molecular complexity
308.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
1
Rotatable bonds
2
Heavy atoms
19
Covalent units
1

Names and synonyms reported to PubChem

3,4,4'-TRICHLOROCARBANILIDECutisanProcuteneSolubacterCusiterGenofaceTrilocarbanUrea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-
16 more reported names
3,4,4'-TrichlorodiphenylureaTrichlocarbanTriclocarbanumN-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)ureaNSC-72005TCC Soap3,4,4'-trichloro carbanilide1-(3',4'-Dichlorophenyl)-3-(4'-chlorophenyl)ureaENT 26925TCC (soap bacteriostat)Carbanilide, 3,4,4'-trichloro-CP 78416N-(3,4-Dichlorophenyl)-N'-(4-chlorophenyl)ureaBGG1Y1ED0YEPA Pesticide Chemical Code 027901CHEBI:48347
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)Cl)Cl
InChI
InChI=1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19)
InChIKey
ICUTUKXCWQYESQ-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:48347

triclocarban

A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.

Formula
C13H9Cl3N2O
Average mass
315.587 g/mol
Monoisotopic mass
313.97805 Da
Formal charge
0
  • phenylureas — is a (CHEBI:134043)
  • dichlorobenzene — is a (CHEBI:23697)
  • monochlorobenzenes — is a (CHEBI:83403)
  • disinfectant — has role (CHEBI:48219)
  • antiseptic drug — has role (CHEBI:48218)
  • xenobiotic — has role (CHEBI:35703)
  • antimicrobial agent — has role (CHEBI:33281)
  • environmental contaminant — has role (CHEBI:78298)
  • 1,3-diphenylurea — has functional parent (CHEBI:41320)
  • disinfectant — has role (CHEBI:48219)
  • antiseptic drug — has role (CHEBI:48218)
  • xenobiotic — has role (CHEBI:35703)
  • antimicrobial agent — has role (CHEBI:33281)
  • environmental contaminant — has role (CHEBI:78298)
  • phenylureas — is a (CHEBI:134043)
  • dichlorobenzene — is a (CHEBI:23697)
  • monochlorobenzenes — is a (CHEBI:83403)
Additional curated names
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea1-(3',4'-dichlorophenyl)-3-(4'-chlorophenyl)urea3,4,4'-trichloro carbanilide3,4,4'-trichlorocarbanilide3,4,4'-trichlorodiphenylureaN-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)ureaNSC-72005TCC
Cross-references from this source
  • CAS: 101-20-2 — NIST Chemistry WebBook
  • CAS: 101-20-2 — ChemIDplus
  • REGISTRY_NUMBER: 2814890 — Reaxys
  • MANUAL_X_REF: 3630 — DrugCentral
  • MANUAL_X_REF: D06223 — KEGG DRUG
  • MANUAL_X_REF: DB11155 — DrugBank
  • MANUAL_X_REF: GB769273 — Patent
  • MANUAL_X_REF: Triclocarban — Wikipedia
  • MANUAL_X_REF: US2818390 — Patent

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2018-12-13. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7547

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H400 (96.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 185 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Triclocarban (TCC) is a solid. It has anti-microbial activity and is used globally in a wide range of personal cleansing products that include deodorant soaps, detergents, cleansing lotions, and wipes. In North America, TCC is used exclusively as an antimicrobial and preservative in bar and liquid soaps and body washes. HUMAN STUDIES: Studies in humans indicate no evidence of skin sensitization or severe irritation. Petrolatum (0.1mL) containing 0, 1, 3, 6, and 9% TCC was applied continuously for 21 days on ten males. Minimal skin irritation was observed with the 9% concentration. There was no evidence of skin sensitization in volunteers tested with TCC (1.5% and 10%). The potential impact of exposure to TCC on fetal abnormalities was studied in 39 pregnant women diagnosed with fetal or post-birth abnormalities. Significantly increased levels of TCC were detected in maternal sera from mothers with abnormal births. TCC was also studied for its endocrine-disrupting effects. TCC exerted estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and dow Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: BCF values for triclocarban in rice fish (Oryzias latipes), exposed for 28 days to 20 and 2.0 ug/L were 80 and 81, respectively(1). A log BCF of 2.86 (BCF = 724) was measured using medaka (Oryzias latipes) exposed to 20 ug/L of triclocarban for 24 hours(2). According to a classification scheme(3), these BCF values suggest bioconcentration in aquatic organisms is moderate to high(SRC). Triclocarban BAFs in algae of 1600 to 2700 from three locations downstream of a waste water treatment plant in Pecan Creek, TX(4). Triclocarban bioaccumulation peaked at day 5 of a 56 day study of worms (Lumbriculus variegatus) in soil containing 22.4 ug/g dry weight triclocarban(5). Body burdens of 25 and 133 ng/g wet wt, corresponding to a biota soil accumulation factor range of 0.22 to 0.7, were reported after 28 days in earthworm (Eisenia foetida) present in 2 soils (Ashkum heavy-textured silty clay loam; Chelsea light-textured fine sand). The soils were amended with municipal (Chicago, IL) biosolids containing an average triclocarban concentration of 9200 ng/g dry wt, resulting in an average trace level soil concentration of 9 ng/g dry wt(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 12,000(2) to 71,687(3) indicate that triclocarban is expected to be immobile in soil(SRC). Volatilization of triclocarban from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.5X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Triclocarban is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.6X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(5). Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is not an important environmental fate process in soil(SRC). However using a continuous flow activated sludge, 50-100% degradation was obtained in 12 weeks, following lag periods of up to two weeks(7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Dewatered municipal biosolids (DMBs) were applied to a field at a rate of approximately 22 Mg dw/ha in October 2008. Pharmaceuticals and personal care products (PPCPs) were monitored in groundwater, tile drainage, soil, DMB aggregates incorporated into the soil post-land application, and in the grain of wheat grown on the field for a period of approximately 1 year following application. Over 80 PPCPs were analyzed in the source DMB. PPCPs selected for in-depth monitoring included ... triclocarban .... PPCPs in tile were observed twice, approximately 3 weeks and 2 months post-application. Of all PPCPs measured in tile drainage, only carbamazepine, ibuprofen, acetaminophen, triclosan, triclocarban, venlafaxine, and citalopram were detected (5-74 ng/L). PPCPs were not detected in groundwater >2 m depth below the soil surface, and concentrations above detection limits at 2 m depth were only observed once just after the first rain event post-application. In groundwater, all compounds found in tile, except carbamazepine, acetaminophen and citalopram, were detected (10-19 ng/L). PPCPs were detected in DMB aggregates incorporated in soil up to 1 year post-application, wit Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 12,000(2) to 71687(3) indicate that triclocarban is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 4.5X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). According to a classification scheme(6), BCF values of 80(7) to 724(8) suggest the potential for bioconcentration in aquatic organisms is moderate to high(SRC). Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks(7) indicating that biodegradation is not an important environmental fate process in water(SRC). However using a continuous flow activated sludge, 50-100% degradation was obtained in 12 weeks, following lag periods of up to two weeks(9). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triclocarban, which has an estimated vapor pressure of 3.6X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase triclocarban may be removed from the air by wet and dry deposition(SRC). Triclocarban contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex B, entry 97
Source record ID
annex-b:97
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1931
current India records
317
records marked Restricted
1931
records from this source version
1836
market records with CAS identity

Status distribution

Prohibited: 1614Restricted: 317

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “1-(4-Chlorophenyl)- 3-(3,4- dichlorophenyl)urea (10) Triclocarban (CAS No. 101-20-2)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex B, entry 97, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

1-(4-Chlorophenyl)- 3-(3,4- dichlorophenyl)urea (10) Triclocarban (CAS No. 101-20-2). IS 4707 (Part 2):2025 Annex B, entry 97. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/16308/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source