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EU cosmetic ingredients, restrictions and safety
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Official EU label nameGlossary entry 8603

DIETHYLHEXYL ADIPATE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 1 of 13 indexed market datasets: 1 country records and 0 EU Annex records. Every result and evidence gap is listed below.

1 markets with evidence
Markets checked
13
Markets with evidence
1
Evidence gaps
12
Resolved identifiers
2

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:103-23-1
EC:203-090-1
Ingredient index records:
DIETHYLHEXYL ADIPATE
Cosmetic functions: FILM FORMING, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

Bis(2-ethylhexyl) adipate

Open full local profile
2 matched or reported names
DIETHYLHEXYL ADIPATEDiethylhexyl Adipate

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

Swipe or scroll horizontally to see dataset coverage and next actions.

MarketResultRecordsDatasetMeaning / next action
European Union
EU
No local match0
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain
GB
No local match0
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Canada
CA
Restricted1Open record 1
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
Review every linked record and exact conditions.
New Zealand
NZ
No local match0
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
ASEAN
ASEAN
No local match0
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
No local match0
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
No local match0
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia
SA
No local match0
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
No market rows match this filter.

Matching market records and conditions

Chemical identity and properties

PubChem 2D chemical structure for CAS 103-23-1
CAS 103-23-1PubChem CID 7641

Bis(2-ethylhexyl) adipate

IUPAC name
bis(2-ethylhexyl) hexanedioate
Molecular formula
C22H42O4
Molecular weight
370.6 g/mol
Exact mass
370.30830982 Da
XLogP3
6.8
Topological polar surface area
52.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Di(2-ethylhexyl) adipateBis(2-ethylhexyl)hexanedioateDiethylhexyl adipateDEHABEHAPlastomoll DOAVestinol OAEffomoll DOA
16 more reported names
Kodaflex DOAMonoplex DOATruflex DOAAdipol 2EHReomol doaStaflex doaUniflex doaLankroflex DOABisoflex DOACrodamol DOAErgoplast ADDOMollan SRucoflex plasticizer doaWickenol 158Sansocizer DOAPlasthall DOA
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34675

bis(2-ethylhexyl) adipate

A diester resulting from the formal condensation of the carboxy groups of adipic acid with 2-ethylhexan-1-ol. It is used as a plasticiser in the preparation of various polymers.

Formula
C22H42O4
Average mass
370.574 g/mol
Monoisotopic mass
370.30831 Da
Formal charge
0
  • diester — is a (CHEBI:51307)
  • carboxylic ester — is a (CHEBI:33308)
  • dicarboxylic acids and O-substituted derivatives — is a (CHEBI:131927)
  • plasticiser — has role (CHEBI:79056)
  • 2-ethylhexan-1-ol — has functional parent (CHEBI:16011)
  • adipic acid — has functional parent (CHEBI:30832)
  • plasticiser — has role (CHEBI:79056)
  • diester — is a (CHEBI:51307)
  • carboxylic ester — is a (CHEBI:33308)
  • dicarboxylic acids and O-substituted derivatives — is a (CHEBI:131927)
Additional curated names
bis(2-ethylhexyl) adipateadipic acid bis(2-ethylhexyl) esterBEHAbis(2-ethylhexyl) hexanedioateDEHADi(2-ethylhexyl) adipateDiethylhexyl adipateDioctyl adipate
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2016-05-16. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7641

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 96.5% (1012 of 1049) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1012 of 1049 companies (only 3.5% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1049 reports by companies from 12 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 1012 of 1049 reports by companies.; There are 10 notifications provided by 37 of 1049 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P261, P271, P280, P304+P340, P318, P319, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • GHS Hazard Statements: Not Classified Source: NITE-CMC
  • GHS Hazard Statements: H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: NITE-CMC
  • NFPA Health Rating: 0 - Materials that, under emergency conditions, would offer no hazard beyond that of ordinary combustible materials. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Environmental Bioconcentration: A whole-fish BCF of 27 was observed for blue-gill fish exposed to bis(2-ethylhexyl) adipate levels of 250 ug/l for a 28-day period(1). According to a classification scheme(2), this measured BCF value suggests the potential for bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 49,000(SRC), determined from a structure estimation method(2), indicates that bis(2-ethylhexyl) adipate is expected to be immobile in soil(SRC). The dominant degradation process in the soil environment is expected to be microbial degradation. Biodegradation test results indicate that bis(2-ethylhexyl) adipate is readily biodegradable(3,4). Therefore, the dominant degradation process in the soil environment is expected to be microbial degradation(SRC). Volatilization of bis(2-ethylhexyl) adipate from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 4.34X10-7atm-cu m/mole(3). Bis(2-ethylhexyl) adipate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.5X10-7mm Hg(3). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 49,000(SRC), determined from an estimation method(2), indicates that bis(2-ethylhexyl) adipate is expected to adsorb to suspended solids and sediment in water(SRC). Biodegradation test results indicate that bis(2-ethylhexyl) adipate is readily biodegradable(4). Therefore, the dominant degradation process in the aquatic environment is expected to be microbial degradation(4). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 4.34X10-7 atm-cu m/mole(4). According to a classification scheme(5), a BCF of 27(4), suggests the potential for bioconcentration in aquatic organisms is low. Bis(2-ethylhexyl) adipate is expected to hydrolyze producing 2-ethylhexanol and hexanoic acid(SRC). Estimated hydrolysis half-lives are 3 years and 120 days at pH values of 7 and 8, respectively(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis(2-ethylhexyl) adipate, which has a vapor pressure of 8.5X10-7 mm Hg at 20 °C(3), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bis(2-ethylhexyl) adipate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 0.63 days(SRC), calculated from its rate constant of 2.5X10-11 cu cm/molecule-sec at 25 °C(4) determined using a structure estimation method(2). Particulate-phase bis(2-ethylhexyl) adipate may be removed from the air by wet and dry deposition(SRC). Bis(2-ethylhexyl) adipate may undergo direct photolysis in the environment, since this compound contains a functional group that can absorb light >290 nm(5). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Anti-caking agent; Fragrance; Plasticizer; Binder; Lubricating agent; Emulsifier; Diluent; Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Dispersing agent; Solvent; Polymerization promoter; Fragrance; Plasticizer; Flavoring and nutrient; Fixing agent (mordant); Wetting agent (non-aqueous); Other; Binder; Lubricating agent; Emulsifier; Diluent; Not Known or Reasonably Ascertainable; Laboratory chemicals Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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Continue the compliance check

1. Confirm identity

Match the supplier specification, CAS/EC identifiers and composition to this official label name. Similar wording is not proof of chemical equivalence.

2. Review restrictions

Check every exact Annex record shown above, plus CMR, nanomaterial, SCCS and later-amendment requirements that may apply.

3. Verify the formula

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

Open official Decision