InventoryRef 7571715/10/2010
DIETHYLHEXYL ADIPATE
Bis(2-ethylhexyl) adipate
DIETHYLHEXYL ADIPATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
Swipe or scroll horizontally to see every column.
| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Source mapped Inventory entry; no linked annex rule | 0 | English and EU languages |
| Great Britain | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Canada | Evidence linked Restricted Open this evidence | 1 | English and French |
| New Zealand | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| ASEAN | Source mapped Official source mapped; ingredient rule not imported | 0 | English and national languages |
| China | Source mapped Official source mapped; ingredient rule not imported | 0 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Source mapped Official source mapped; ingredient rule not imported | 0 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Source mapped Official source mapped; ingredient rule not imported | 0 | Portuguese with INCI crosswalks |
| India | Source mapped Official source mapped; ingredient rule not imported | 0 | English and Hindi |
| Saudi Arabia | Source mapped Official source mapped; ingredient rule not imported | 0 | Arabic and English |
Chemical identity and properties
CAS 103-23-1PubChem CID 7641
Bis(2-ethylhexyl) adipate
Bis(2-ethylhexyl) adipate is a diester resulting from the formal condensation of the carboxy groups of adipic acid with 2-ethylhexan-1-ol. It is used as a plasticiser in the preparation of various polymers. It has a role as a plasticiser. It is a member of dicarboxylic acids and O-substituted derivatives, a carboxylic ester and a diester. It is functionally related to a 2-ethylhexan-1-ol and an adipic acid. — ChEBI
- IUPAC name
- bis(2-ethylhexyl) hexanedioate
- Molecular formula
- C22H42O4
- Molecular weight
- 370.6 g/mol
- Exact mass
- 370.30830982 Da
- XLogP3
- 6.8
- Topological polar surface area
- 52.6 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Di(2-ethylhexyl) adipateBis(2-ethylhexyl)hexanedioateDiethylhexyl adipateDEHABEHAPlastomoll DOAVestinol OAEffomoll DOA
16 more reported names
Kodaflex DOAMonoplex DOATruflex DOAAdipol 2EHReomol doaStaflex doaUniflex doaLankroflex DOABisoflex DOACrodamol DOAErgoplast ADDOMollan SRucoflex plasticizer doaWickenol 158Sansocizer DOAPlasthall DOA
External database identifiers
- ChEBI:CHEBI:34675
- ChEMBL:CHEMBL1414950
- EPA DTXSID:DTXSID0020606
- PubMed:22346617
- PubMed:21783615
- PubMed:21714626
- PubMed:21575223
- PubMed:21400322
- PubMed:20681565
- PubMed:20414453
- PubMed:20392686
- PubMed:20352652
- PubMed:20334193
- PubMed:19957297
- PubMed:19842066
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:34675
bis(2-ethylhexyl) adipate
A diester resulting from the formal condensation of the carboxy groups of adipic acid with 2-ethylhexan-1-ol. It is used as a plasticiser in the preparation of various polymers.
- Formula
- C22H42O4
- Average mass
- 370.574 g/mol
- Monoisotopic mass
- 370.30831 Da
- Formal charge
- 0
- diester — is a (CHEBI:51307)
- carboxylic ester — is a (CHEBI:33308)
- dicarboxylic acids and O-substituted derivatives — is a (CHEBI:131927)
- plasticiser — has role (CHEBI:79056)
- 2-ethylhexan-1-ol — has functional parent (CHEBI:16011)
- adipic acid — has functional parent (CHEBI:30832)
- plasticiser — has role (CHEBI:79056)
- diester — is a (CHEBI:51307)
- carboxylic ester — is a (CHEBI:33308)
- dicarboxylic acids and O-substituted derivatives — is a (CHEBI:131927)
Additional curated names
bis(2-ethylhexyl) adipateadipic acid bis(2-ethylhexyl) esterBEHAbis(2-ethylhexyl) hexanedioateDEHADi(2-ethylhexyl) adipateDiethylhexyl adipateDioctyl adipate
Cross-references from this source
- CAS: 103-23-1 — KEGG COMPOUND
- CAS: 103-23-1 — ChemIDplus
- CAS: 103-23-1 — NIST Chemistry WebBook
- REGISTRY_NUMBER: 1803774 — Reaxys
- MANUAL_X_REF: Bis(2-ethylhexyl)_adipate — Wikipedia
- MANUAL_X_REF: C14240 — KEGG COMPOUND
- MANUAL_X_REF: HMDB0040270 — HMDB
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2016-05-16. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7641
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 710 °F (NTP, 1992) Source: CAMEO Chemicals
- Autoignition Temperature: 710 °F (377 °C) Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 783 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 214 °C @ 5 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 416.00 to 418.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Color/Form: COLORLESS OR VERY PALE AMBER LIQ Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Light colored, oily liquid. Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.923 (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.922 @ 25 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.922 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Flash Point: 385 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 196 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 402 °F (206 °C) (OPEN CUP) Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -90 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: -67.8 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -67.8 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -67.8 °C Source: PAC Chemical Database, U.S. Department of Energy
- Odor: SLIGHT AROMATIC SMELL Source: Hazardous Substances Data Bank (HSDB)
- Odor: Odorless Source: Hazardous Substances Data Bank (HSDB)
- Odor: Mild Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Bis(2-ethylhexyl) adipate is a colorless to straw-colored liquid with a mild odor. Floats on water. (USCG, 1999) Source: CAMEO Chemicals
- Physical Description: Large Crystals; Liquid; Liquid; Liquid; Other Solid; CBI Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Light-colored, oily liquid; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Refractive Index: Index of refraction: 1.4474 @ 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: less than 0.1 mg/mL at 72 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: SOL IN MOST ORG SOLVENTS; INSOL OR VERY SLIGHTLY SOL IN GLYCERINE & GLYCOLS Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in ethanol, ethyl ether, acetone, and acetic acid Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 0.78 mg/l @ 22 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 0.00078 mg/mL at 22 °C Source: Human Metabolome Database (HMDB)
- Vapor Pressure: less than 0.01 mmHg at 68 °F ; 2.6 mmHg at 392 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 0.00000085 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 8.5X10-7 mm Hg at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Viscosity: 13.7 cP @ 20 °C Source: Hazardous Substances Data Bank (HSDB)
- pH: Acidity: 0.25 (meg/100 gm. max) Source: Hazardous Substances Data Bank (HSDB)
- IARC Carcinogenic Agent: Di(2-ethylhexyl) adipate Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print); Volume 77: (2000) Some Industrial Chemicals Source: International Agency for Research on Cancer (IARC)
- Publication Year: 2000 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 2000 Source: International Agency for Research on Cancer (IARC)
- Substance: Di(2-ethylhexyl) adipate Source: NTP Technical Reports
- NTP Technical Report: TR-212: Carcinogenesis Bioassay of Di(2-ethylhexyl)adipate (CASRN 103-23-1) in F344 Rats and B6C3F1 Mice (Feed Study) (1982 ) Source: NTP Technical Reports
- Peer Review Date: 06/27/80 Source: NTP Technical Reports
- Conclusion for Male Rat: No Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: Clear Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: Clear Evidence Source: NTP Technical Reports
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
- Note: This chemical does not meet GHS hazard criteria for 96.5% (1012 of 1049) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1012 of 1049 companies (only 3.5% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1049 reports by companies from 12 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 1012 of 1049 reports by companies.; There are 10 notifications provided by 37 of 1049 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
- Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: NITE-CMC
- Precautionary Statement Codes: P203, P261, P271, P280, P304+P340, P318, P319, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
- GHS Hazard Statements: Not Classified Source: NITE-CMC
- GHS Hazard Statements: H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: NITE-CMC
- NFPA Health Rating: 0 - Materials that, under emergency conditions, would offer no hazard beyond that of ordinary combustible materials. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Developmental; Hepatic; Musculoskeletal; Urinary Source: EPA Integrated Risk Information System (IRIS)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Environmental Bioconcentration: A whole-fish BCF of 27 was observed for blue-gill fish exposed to bis(2-ethylhexyl) adipate levels of 250 ug/l for a 28-day period(1). According to a classification scheme(2), this measured BCF value suggests the potential for bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 49,000(SRC), determined from a structure estimation method(2), indicates that bis(2-ethylhexyl) adipate is expected to be immobile in soil(SRC). The dominant degradation process in the soil environment is expected to be microbial degradation. Biodegradation test results indicate that bis(2-ethylhexyl) adipate is readily biodegradable(3,4). Therefore, the dominant degradation process in the soil environment is expected to be microbial degradation(SRC). Volatilization of bis(2-ethylhexyl) adipate from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 4.34X10-7atm-cu m/mole(3). Bis(2-ethylhexyl) adipate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.5X10-7mm Hg(3). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 49,000(SRC), determined from an estimation method(2), indicates that bis(2-ethylhexyl) adipate is expected to adsorb to suspended solids and sediment in water(SRC). Biodegradation test results indicate that bis(2-ethylhexyl) adipate is readily biodegradable(4). Therefore, the dominant degradation process in the aquatic environment is expected to be microbial degradation(4). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 4.34X10-7 atm-cu m/mole(4). According to a classification scheme(5), a BCF of 27(4), suggests the potential for bioconcentration in aquatic organisms is low. Bis(2-ethylhexyl) adipate is expected to hydrolyze producing 2-ethylhexanol and hexanoic acid(SRC). Estimated hydrolysis half-lives are 3 years and 120 days at pH values of 7 and 8, respectively(6). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis(2-ethylhexyl) adipate, which has a vapor pressure of 8.5X10-7 mm Hg at 20 °C(3), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bis(2-ethylhexyl) adipate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 0.63 days(SRC), calculated from its rate constant of 2.5X10-11 cu cm/molecule-sec at 25 °C(4) determined using a structure estimation method(2). Particulate-phase bis(2-ethylhexyl) adipate may be removed from the air by wet and dry deposition(SRC). Bis(2-ethylhexyl) adipate may undergo direct photolysis in the environment, since this compound contains a functional group that can absorb light >290 nm(5). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Anti-caking agent; Fragrance; Plasticizer; Binder; Lubricating agent; Emulsifier; Diluent; Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Dispersing agent; Solvent; Polymerization promoter; Fragrance; Plasticizer; Flavoring and nutrient; Fixing agent (mordant); Wetting agent (non-aqueous); Other; Binder; Lubricating agent; Emulsifier; Diluent; Not Known or Reasonably Ascertainable; Laboratory chemicals Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Diethylhexyl Adipate Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used as a plasticizer, in processing polyvinyl and other polymers, as a solvent, in aircraft lubricants, and in hydraulic fluids; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Plasticizer, commonly blended with general purpose plasticizers, such as /di-n-octyl phthalate/ and /diisooctyl phthalate/ in processing polyvinyl and other polymers; solvent; aircraft lubes Source: Hazardous Substances Data Bank (HSDB)
- Uses: Functional (hydraulic) fluid Source: Hazardous Substances Data Bank (HSDB)
- Uses: Plasticizer or solvent in the following cosmetics: bath oils, eye shadow, cologne, foundations, rouge, blusher, nail-polish remover, moisturizers and indoor tanning preparations Source: Hazardous Substances Data Bank (HSDB)
- Uses: ... PVC film now used in meat wrapping operations contains bis(2-ethyl hexyl) adipate (DOA) as its major plasticizer. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Plastics -> Typical concentration range in plastic materials -> 10.0 - 35.0% Source: NORMAN Suspect List Exchange
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for DIETHYLHEXYL ADIPATE
INCI name
DIETHYLHEXYL ADIPATE
Description
Bis(2-ethylhexyl) adipate
Record provenance
- Inventory reference
- 75717
- Imported identity
- DIETHYLHEXYL ADIPATE
- Source update
- 15/10/2010
Annex records for DIETHYLHEXYL ADIPATE
Key data
CAS
EC
Restriction
—
Function
- FILM FORMING
- Producing (upon application) a continuous film on the skin, hair or nails.
- PLASTICISER
- Softening and making supple synthetic polymers that otherwise could not be easily deformed, spread or worked out.
- SKIN CONDITIONING
- Maintaining the skin in good condition.
- SKIN CONDITIONING - EMOLLIENT
- Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.
- SOLVENT
- Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How DIETHYLHEXYL ADIPATE appears in the CosIng inventory
The CosIng inventory lists DIETHYLHEXYL ADIPATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
DIETHYLHEXYL ADIPATE is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
DIETHYLHEXYL ADIPATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, DIETHYLHEXYL ADIPATE carries the following function designation(s):
CAS 103-23-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for DIETHYLHEXYL ADIPATE
This page reproduces the CosIng inventory entry for DIETHYLHEXYL ADIPATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research DIETHYLHEXYL ADIPATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
Check your formula
Scan a full INCI list to detect DIETHYLHEXYL ADIPATE and any linked EU annex restrictions or allergen flags.
INCI CheckerSearch similar ingredients
Find other inventory ingredients and annex entries related to DIETHYLHEXYL ADIPATE, its identifiers or nearby name variants.
Search