Official EU label nameGlossary entry 16618
METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 5 of 13 indexed market datasets: 7 country records and 1 EU Annex records. Every result and evidence gap is listed below.
Markets checked
13
Markets with evidence
5
Evidence gaps
8
Resolved identifiers
2
Resolved substance identity
CAS:103597-45-1
EC:403-800-1
Ingredient index records:
METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
Cosmetic functions: LIGHT STABILIZER, UV FILTER
2,2'-Methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)
Inventory restriction note: VI/23
10 matched or reported names
METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOLbisoctrizole2,2'-Methylene bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) / BisoctrizoleMethylene Bis-Benzotriazolyl TetramethylbutylphenolMethylene Bis-Benzotriazolyl Tetramethylbutylphenol (nano)2,2'-Methylene-bis-6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)2,2′-Methylene-bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) (nano) (methylene bis-benzotriazolyl tetramethylbutylphenol (nano), bisoctrizole (nano))2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol/MBBT) CAS No. 103597-45-12,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45-1메칠렌비스-벤조트리아졸릴테트라메칠부틸페놀
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
Swipe or scroll horizontally to see dataset coverage and next actions.
| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | Conditional positive-list match | 1Open record 1 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | Review every linked record and exact conditions. |
| Great Britain GB | Permitted list with conditions | 2Open record 1Open record 2 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | Review every linked record and exact conditions. |
| Canada CA | No local match | 0 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | The Hotlist is an administrative compliance tool, not an exhaustive safety approval list. |
| New Zealand NZ | Permitted list with conditions | 2Open record 1Open record 2 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | Review every linked record and exact conditions. |
| ASEAN ASEAN | Permitted list with conditions | 2Open record 1Open record 2 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Review every linked record and exact conditions. |
| China CN | No local match | 0 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | Restricted | 1Open record 1 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Review every linked record and exact conditions. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | No local match | 0 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction. |
| Brazil BR | No local match | 0 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026. |
| India IN | No local match | 0 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | The standards are separate controlled publications; absence from a locally indexed excerpt is not permission. |
| Saudi Arabia SA | No local match | 0 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply. |
No market rows match this filter.
Matching market records and conditions
Great Britain
GB retained Regulation 1223/2009 schedules, effective 15 August 2026Methylene Bis-Benzotriazolyl TetramethylbutylphenolPermitted list with conditions
10%
GB Cosmetics Regulation, Annex VI, entry 23 · 2026-08-15
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (nano)Permitted list with conditions
10% · Not to be used in applications that may lead to exposure of the end user's lungs by inhalation. Only nanomaterials having the following characteristics are allowed: Purity ≥ 98,5%, with 2,2′-methylene-bis-(6(2H-benzotriazol-2-yl)-4-(isooctyl)phenol) isomer fraction not exc…
GB Cosmetics Regulation, Annex VI, entry 23a · 2026-08-15
New Zealand
Cosmetic Products Group Standard schedules effective 1 January 20262,2'-Methylene-bis-6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)Permitted list with conditions
Maximum concentration: 10%
Schedule 8, reference 23, source row 26 · effective-2026-01-01
2,2′-Methylene-bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) (nano) (methylene bis-benzotriazolyl tetramethylbutylphenol (nano), bisoctrizole (nano))Permitted list with conditions
Maximum concentration: 10% · Other limitations: Not to be used in applications that may lead to exposure of the end user's lungs by inhalation Only nanomaterials having the following characteristics are allowed: - Purity: ≥ 98.5%, with 2,2′-methylene-bis-(6(2H-benzotriazol-2-yl)…
Schedule 8, reference 23a, source row 27 · effective-2026-01-01
ASEAN
ASEAN Cosmetic Directive annexes 2026-1, 22 June 20262,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol/MBBT) CAS No. 103597-45-1Permitted list with conditions
10%(5)
ASEAN Annex VII, reference 23 · 2026-1
2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45-1Permitted list with conditions
10%(5) · Not to be used in applications that may lead to exposure of the end user's lungs by inhalation. Only nanomaterials having the following characteristics are allowed: - Purity ≥ 98.5 %, with 2,2′- methylene-bis-(6(2H- benzotriazol-2-yl)-4- (isooctyl)phenol) isomer fractio…
ASEAN Annex VII, reference 23a · 2026-1
South Korea
MFDS Notice 2026-19, effective 18 March 2026Exact Annex II–VI evidence
Annex VIentry 23
Open full regulatory recordMETHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
Maximum concentration: 10%
Chemical identity and properties
- IUPAC name
- 2-(benzotriazol-2-yl)-6-[[3-(benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
- Molecular formula
- C41H50N6O2
- Molecular weight
- 658.9 g/mol
- Exact mass
- 658.39952486 Da
- XLogP3
- 12.8
- Topological polar surface area
- 102.0 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 6
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
FAT 75'634Bisoctrizole [USAN]Bisoctrizol8NT850T0YSNSC-759873BISOCTRIZOLE [MI]FAT-75634BISOCTRIZOLE [INN]
16 more reported names
BISOCTRIZOLE [MART.]BISOCTRIZOLE [USP-RS]BISOCTRIZOLE [WHO-DD]BISOCTRIZOLE [USP MONOGRAPH]2-(2H-1,2,3-benzotriazol-2-yl)-6-{[3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl}-4-(2,4,4-trimethylpentan-2-yl)phenolPhenol, 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-Phenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-BISOCTRIZOLE (MART.)BISOCTRIZOLE (USP-RS)BISOCTRIZOLE (USP MONOGRAPH)2,2'-METHYLENEBIS(6-(2-BENZOTRIAZOLYL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL2,2'-METHYLENEBIS(6-(2-BENZOTRIAZOLYL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL)PHENOL, 2,2'-METHYLENEBIS(6-(2H-BENZOTRIALZOL-2-YL)-4-(1,1,3,3-TETRAMETHYLBUTYL)-bisoctrizolumPhenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl]-4-(1,1,3,3-tetramethylbutyl)-2-(2H-1,2,3-benzotriazol-2-yl)-6-((3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol
External database identifiers
- ChEBI:CHEBI:135865
- ChEMBL:CHEMBL2104957
- EPA DTXSID:DTXSID2046703
- PubMed:23320122
- PubMed:21504696
- PubMed:20038348
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:135865
bisoctrizole
- Formula
- C41H50N6O2
- Average mass
- 658.891 g/mol
- Monoisotopic mass
- 658.39952 Da
- Formal charge
- 0
- diarylmethane — is a (CHEBI:51614)
- diarylmethane — is a (CHEBI:51614)
Additional curated names
bisoctyltriazoleFAT 75'634FAT-75634MBBTNSC-759873
Cross-references from this source
- CAS: 103597-45-1 — DrugCentral
- MANUAL_X_REF: 3031 — DrugCentral
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-02-23. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match3571576
Attributed physical-property, hazard, environmental and use annotations.
- LogP: 12.7 Source: DrugBank
- Melting Point: 195 Source: DrugBank
- Physical Description: Other Solid; Dry Powder; Large Crystals Source: EPA Chemical Data Reporting (CDR)
- Solubility: < 5 ng/L at 25 °C Source: DrugBank
- GHS Hazard Statements: H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for 1.7% (14 of 842) of reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H413 (98.3%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 842 reports by companies from 4 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 14 of 842 reports by companies.; There are 3 notifications provided by 828 of 842 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 107 reports by companies from 1 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Consumer Uses: UV stabilizer; Other Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Stabilizing agent; Other; UV stabilizer Source: EPA Chemical Data Reporting (CDR)
- Uses: Plastics -> Typical concentration range in plastic materials -> 0.2 - 6.0% Source: NORMAN Suspect List Exchange
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Additional authoritative substance research
Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight
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Official source and scope
Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.
Open official Decision