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Annex VI Entry 23 27/07/2020

METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL

2,2'-Methylene bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) / Bisoctrizole

METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL appears in Annex VI as a positive-list UV filter entry for EU cosmetics. Maximum concentration in this record: 10%.

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Permitted UV filter— Annex VI, EU Regulation 1223/2009
Max conc.: 10%
Entry: 23

Chemical identity and properties

PubChem 2D chemical structure for CAS 103597-45-1
CAS 103597-45-1PubChem CID 3571576

Bisoctrizole

Bisoctrizole is a diarylmethane. — ChEBI

IUPAC name
2-(benzotriazol-2-yl)-6-[[3-(benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
Molecular formula
C41H50N6O2
Molecular weight
658.9 g/mol
Exact mass
658.39952486 Da
XLogP3
12.8
Topological polar surface area
102.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

FAT 75'634Bisoctrizole [USAN]Bisoctrizol8NT850T0YSNSC-759873BISOCTRIZOLE [MI]FAT-75634BISOCTRIZOLE [INN]
16 more reported names
BISOCTRIZOLE [MART.]BISOCTRIZOLE [USP-RS]BISOCTRIZOLE [WHO-DD]BISOCTRIZOLE [USP MONOGRAPH]2-(2H-1,2,3-benzotriazol-2-yl)-6-{[3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl}-4-(2,4,4-trimethylpentan-2-yl)phenolPhenol, 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-Phenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-BISOCTRIZOLE (MART.)BISOCTRIZOLE (USP-RS)BISOCTRIZOLE (USP MONOGRAPH)2,2'-METHYLENEBIS(6-(2-BENZOTRIAZOLYL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL2,2'-METHYLENEBIS(6-(2-BENZOTRIAZOLYL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL)PHENOL, 2,2'-METHYLENEBIS(6-(2H-BENZOTRIALZOL-2-YL)-4-(1,1,3,3-TETRAMETHYLBUTYL)-bisoctrizolumPhenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl]-4-(1,1,3,3-tetramethylbutyl)-2-(2H-1,2,3-benzotriazol-2-yl)-6-((3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:135865

bisoctrizole

Formula
C41H50N6O2
Average mass
658.891 g/mol
Monoisotopic mass
658.39952 Da
Formal charge
0
  • diarylmethane — is a (CHEBI:51614)
  • diarylmethane — is a (CHEBI:51614)
Additional curated names
bisoctyltriazoleFAT 75'634FAT-75634MBBTNSC-759873
Cross-references from this source
  • CAS: 103597-45-1 — DrugCentral
  • MANUAL_X_REF: 3031 — DrugCentral

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-02-23. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match3571576

Attributed physical-property, hazard, environmental and use annotations.

  • Solubility: < 5 ng/L at 25 °C Source: DrugBank
  • GHS Hazard Statements: H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 1.7% (14 of 842) of reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H413 (98.3%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 842 reports by companies from 4 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 14 of 842 reports by companies.; There are 3 notifications provided by 828 of 842 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 107 reports by companies from 1 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Uses: Plastics -> Typical concentration range in plastic materials -> 0.2 - 6.0% Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

10%

INCI glossary name

METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL

Chemical name

2,2'-Methylene bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) / Bisoctrizole

Chemical / IUPAC name

2,2'-Methylene bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) / Bisoctrizole

Regulatory information

Regulation

(EU) 2018/885

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
103597-45-1
EC
403-800-1
Annex
VI
Entry number
23

Inventory links for METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL

Direct matches are limited for this record, so nearby entries from Annex VI are shown as well.

Annex VI 26
Nearby record in the same annex

Polysilicone-15

CAS: 207574-74-1
EC: 426-000-4
Annex VI 27a
Nearby record in the same annex

TITANIUM DIOXIDE (NANO)

CAS: 13463-67-7[1]/ 1317-70-0[2]/ 1317-80-2[3]
EC: 236-675-5[1] /215-280-1[2]/ 215-282-2[3]
Annex VI 27
Nearby record in the same annex

TITANIUM DIOXIDE

CAS: 13463-67-7[1]/ 1317-70-0[2]/ 1317-80-2[3]
EC: 236-675-5[1] /215-280-1[2]/215-282-2 [ 3]

What Annex VI means for METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL

METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL is an approved UV filter listed in Annex VI of EU Cosmetics Regulation 1223/2009. Only UV filters included in this positive list may be used to provide UV protection in EU cosmetic products.

The maximum permitted concentration specified in this entry applies to the ready-to-use product. Some UV filters are restricted to specific application types or require label warnings.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 11 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Concentration in ready-to-use product must not exceed: 10%
  • Check whether the UV filter is approved for both leave-on and rinse-off applications.

Frequently asked questions

Yes. METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL is listed in Annex VI of EU Cosmetics Regulation 1223/2009 as a permitted UV filter. It may be used at concentrations up to the specified maximum in the ready-to-use product.

CAS 103597-45-1 is the unique numerical identifier assigned to METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 10% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex VI record METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL

This page summarizes one Annex VI record for METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex VI conditions for METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL, but confirm any final regulatory decision against the current official annex wording and source files.

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