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Annex VI Entry 22 15/10/2010

Benzophenone-4; Benzophenone-5

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (Benzophenone-5) and its sodium salt / Sulisobenzone

Benzophenone-4; Benzophenone-5 appears in Annex VI as a positive-list UV filter entry for EU cosmetics. Maximum concentration in this record: 5%(as acid).

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Permitted UV filter— Annex VI, EU Regulation 1223/2009
Max conc.: 5%(as acid)
Entry: 22

Chemical identity and properties

PubChem 2D chemical structure for CAS 4065-45-6
CAS 4065-45-6PubChem CID 19988

Sulisobenzone

Sulisobenzone is a member of benzophenones. — ChEBI

IUPAC name
5-benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
Molecular formula
C14H12O6S
Molecular weight
308.31 g/mol
Exact mass
308.03545927 Da
XLogP3
2.2
Topological polar surface area
109.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

Benzophenone-42-Hydroxy-4-methoxybenzophenone-5-sulfonic acidSungardUvalBenzophenone 4Seesorb 101SSyntase 230Spectra-Sorb UV 284
16 more reported names
SulisobenzonaUvinul MS 40Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-SulfisobenzoneSulisobenzonumUvinul MS-40MS 40Uvinuc ms 40Uvasorb s 5Escalol 577Viosorb 111NSC-60584Uvinul d 50303-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid1W6L629B4K2-Benzoyl-5-methoxy-1-phenol-4-sulfonic acid
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6628-37-1
CAS 6628-37-1PubChem CID 23674885

Benzophenone-5

IUPAC name
sodium 5-benzoyl-4-hydroxy-2-methoxybenzenesulfonate
Molecular formula
C14H11NaO6S
Molecular weight
330.29 g/mol
Exact mass
330.01740352 Da
Topological polar surface area
112.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
6
Covalent units
2
Defined stereocentres
0

Also known as

Sulibenzone2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium saltCyasorb UV 284Uvistat 112853Z42ZYAS2-Hydroxy-4-methoxybenzophenone-5-sodium sulfonatesulisobenzone sodiumBENZOPHENONE 5
16 more reported names
ASL 24STBenzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-, monosodium saltUVIN 1MS40UVISTAT 1121SODIUM 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONATESODIUM 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULPHONATESODIUM BENZOPHENONE-2-HYDROXY-4-METHOXY-5-SULFONATESODIUM 5-BENZOYL-4-HYDROXY-2-METHOXYBENZENESULPHONATESODIUM BENZOPHENONE-2-HYDROXY-4-METHOXY-5-SULPHONATEBENZENESULFONIC ACID, 5-BENZOYL-4-HYDROXY-2-METHOXY-, SODIUM SALT (1:1)Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-, sodium saltRefChem:566260BENZOPHENONE-5 [INCI]613-918-7UNII-853Z42ZYASNSC 60584
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

5%(as acid)

INCI glossary name

Benzophenone-4; Benzophenone-5

Chemical name

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (Benzophenone-5) and its sodium salt / Sulisobenzone

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
4065-45-6 / 6628-37-1
EC
223-772-2 / -
Annex
VI
Entry number
22

Inventory links for Benzophenone-4; Benzophenone-5

Inventory Restriction reference
Ref 32143

BENZOPHENONE-4

CAS: 4065-45-6
EC: 223-772-2
Inventory Restriction reference
Ref 32144

BENZOPHENONE-5

CAS: 6628-37-1
EC: 613-918-7

Direct matches are limited for this record, so nearby entries from Annex VI are shown as well.

Annex VI 26
Nearby record in the same annex

Polysilicone-15

CAS: 207574-74-1
EC: 426-000-4
Annex VI 27a
Nearby record in the same annex

TITANIUM DIOXIDE (NANO)

CAS: 13463-67-7[1]/ 1317-70-0[2]/ 1317-80-2[3]
EC: 236-675-5[1] /215-280-1[2]/ 215-282-2[3]

What Annex VI means for Benzophenone-4; Benzophenone-5

Benzophenone-4; Benzophenone-5 is an approved UV filter listed in Annex VI of EU Cosmetics Regulation 1223/2009. Only UV filters included in this positive list may be used to provide UV protection in EU cosmetic products.

The maximum permitted concentration specified in this entry applies to the ready-to-use product. Some UV filters are restricted to specific application types or require label warnings.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Concentration in ready-to-use product must not exceed: 5%(as acid)
  • Check whether the UV filter is approved for both leave-on and rinse-off applications.

Frequently asked questions

Yes. Benzophenone-4; Benzophenone-5 is listed in Annex VI of EU Cosmetics Regulation 1223/2009 as a permitted UV filter. It may be used at concentrations up to the specified maximum in the ready-to-use product.

CAS 4065-45-6 / 6628-37-1 is the unique numerical identifier assigned to Benzophenone-4; Benzophenone-5 by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 5%(as acid) applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex VI record Benzophenone-4; Benzophenone-5

This page summarizes one Annex VI record for Benzophenone-4; Benzophenone-5 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex VI conditions for Benzophenone-4; Benzophenone-5, but confirm any final regulatory decision against the current official annex wording and source files.

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