What does the restriction note for BENZOPHENONE-4 mean?

The restriction field for BENZOPHENONE-4 reads: VI/22. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 4065-45-6?

CAS 4065-45-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains BENZOPHENONE-4?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3214306/08/2020

BENZOPHENONE-4

5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid

BENZOPHENONE-4 is linked to 1 EU annex record on this page. Inventory note: VI/22.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Positive-list entry with conditions Open this evidence	1	English and EU languages
Great Britain	Evidence linked Permitted list with conditions Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Permitted list with conditions Open this evidence	1	English
ASEAN	Evidence linked Permitted list with conditions Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Restricted Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 4065-45-6

CAS 4065-45-6PubChem CID 19988

Sulisobenzone

Sulisobenzone is a member of benzophenones. — ChEBI

IUPAC name: 5-benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid

Molecular formula: C14H12O6S
Molecular weight: 308.31 g/mol
Exact mass: 308.03545927 Da
XLogP3: 2.2
Topological polar surface area: 109.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

Benzophenone-42-Hydroxy-4-methoxybenzophenone-5-sulfonic acidSungardUvalBenzophenone 4Seesorb 101SSyntase 230Spectra-Sorb UV 284

16 more reported names

SulisobenzonaUvinul MS 40Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-SulfisobenzoneSulisobenzonumUvinul MS-40MS 40Uvinuc ms 40Uvasorb s 5Escalol 577Viosorb 111NSC-60584Uvinul d 50303-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid1W6L629B4K2-Benzoyl-5-methoxy-1-phenol-4-sulfonic acid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:135312
ChEMBL:CHEMBL2059073
EPA DTXSID:DTXSID2042436
PubMed:26016852
PubMed:24407064
PubMed:23815618
PubMed:22189380
PubMed:21807473
PubMed:21272034
PubMed:20937294
PubMed:20363401
PubMed:19854348
PubMed:19645264
PubMed:18498461
PubMed:18455898

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BENZOPHENONE-4

INCI name

BENZOPHENONE-4

INN name

sulisobenzone

Description

5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid

Record provenance

Inventory reference: 32143
Imported identity: BENZOPHENONE-4
Source update: 06/08/2020

European Commission CosIng source notes

Annex records for BENZOPHENONE-4

Annex VI Restriction reference

Entry 22

Benzophenone-4; Benzophenone-5

CAS: 4065-45-6 / 6628-37-1

EC: 223-772-2 / -

Key data

CAS

4065-45-6

223-772-2

Restriction

VI/22

Function

LIGHT STABILIZER: Protecting the cosmetic product from deterioration effects of light.
UV ABSORBER: Protecting the cosmetic product from the effects of UV-light.
UV FILTER: Exclusively or mainly intended to protect the skin and/or hair against certain UV radiation by absorbing, reflecting or scattering UV radiation. All authorised UV filters are substances in the positive list of Annex VI to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#3222 · BENZOPHENONE-4

The 5 markets that hold a rule for this substance do not classify it the same way.

restricted: South Korea
permitted on a positive list: European Union Great Britain New Zealand ASEAN

See every substance the markets disagree about

Ingredients with overlapping formulation functions

ALPHA-VINIFERINUV FILTER

ASTER YOMENA EXTRACTSKIN CONDITIONING, SOLVENT, SURFACE MODIFIER, UV FILTER

BACILLUS LYSATESKIN PROTECTING, UV FILTER

BENZOPHENONE-3LIGHT STABILIZER, UV ABSORBER, UV FILTER

BENZOPHENONE-5LIGHT STABILIZER, UV ABSORBER, UV FILTER

BENZYLIDENE CAMPHOR SULFONIC ACIDLIGHT STABILIZER, UV ABSORBER, UV FILTER

BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINEUV FILTER

BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINEHAIR CONDITIONING, LIGHT STABILIZER, UV ABSORBER, UV FILTER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How BENZOPHENONE-4 appears in the CosIng inventory

The CosIng inventory lists BENZOPHENONE-4 as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BENZOPHENONE-4 is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BENZOPHENONE-4 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for BENZOPHENONE-4 reads: "VI/22". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, BENZOPHENONE-4 carries the following function designation(s):

CAS 4065-45-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for BENZOPHENONE-4

This page combines the CosIng inventory entry for BENZOPHENONE-4 with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research BENZOPHENONE-4 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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