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CAS 1 record

CAS 3380-34-5

CAS 3380-34-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 3380-34-5
CAS 3380-34-5PubChem CID 5564

Triclosan

Triclosan is an aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. It has a role as an EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor, a fungicide, an antibacterial agent, a xenobiotic, an antimalarial, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, a persistent organic pollutant and a drug allergen. It is a dichlorobenzene, a member of phenols, an aromatic ether and a member of monochlorobenzenes. — ChEBI

IUPAC name
5-chloro-2-(2,4-dichlorophenoxy)phenol
Molecular formula
C12H7Cl3O2
Molecular weight
289.5 g/mol
Exact mass
287.951163 Da
XLogP3
5.0
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Cloxifenolum2,4,4'-Trichloro-2'-hydroxydiphenyl etherTriclosanumIrgasan DP300Stri-Dex Cleansing BarStri-Dex Face WashCH 3565Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
16 more reported names
Lexol 3005-Chloro-2-(2,4-dichloro-phenoxy)-phenolCH-3565Phenyl ether, 2'-hydroxy-2,4,4'-trichloro-NSC-759151CHEBI:1642004NM5039Y5XtriclosanoGermasidolClearskinDermacareFreshandsGermicidaPacificPanachePrevens
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 3380-34-5

1 total
Annex
V
Entry
25

Triclosan

5-Chloro-2-(2,4-dichlorophenoxy)phenol

For toothpaste containing Triclosan the following labelling is obligatory: ‘Not to be used for children under 3 years of age’.

EC
222-182-2
Max concentration

How CAS 3380-34-5 is used on this site

CAS 3380-34-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 3380-34-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 3380-34-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.
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