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Annex III Source last update: 02/03/2026

Restricted cosmetic substances

LIST OF SUBSTANCES WHICH COSMETIC PRODUCTS MUST NOT CONTAIN EXCEPT SUBJECT TO THE RESTRICTIONS LAID DOWN

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CosIng Checker is an independent reference website built from publicly available European Commission cosmetic ingredient materials, including Annex II–VI datasets.

Use these pages for research, discovery and comparison, but verify critical regulatory decisions against the official source text and current law.

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Records

373 total
Entry
200

HC VIOLET NO. 2

1-Propanol, 3-[[4-[bis(2-hydroxyethyl)amino]-2-nitrophenyl]amino] (see note 17)

Can cause allergic reaction

CAS
104226-19-9
EC
410-910-3
Max concentration Product type 30/05/2013
Entry
200

TETRAAMINOPYRIMIDINE SULFATE

2,4,5,6-Tetraaminopyrimidine sulphate

(a) To be printed on the la­bel: The mixing ratio. “Hair colourants can cause severe allergic reac­tions. Read and follow instruc­tions. This product is not in­tended for use on persons under the age of 16. Temporary ‘b…

CAS
5392-28-9
EC
226-393-0
Max concentration Product type 27/07/2020
Entry
201

2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL

Phenol, 2-Chloro-6-(ethylamino)-4-nitro- (see note 17)

Can cause allergic reaction

CAS
131657-78-8
EC
411-440-1
Max concentration Product type 05/06/2014
Entry
202

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE

4,4'-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt (see note 17)

(a) The mixing ratio: Hair colorants can cause severe allergic reactions. (b) Can cause allergic reaction

CAS
81892-72-0 - 74918-21-1
EC
279-845-4 - 278-022-7
Product type 25/07/2013
Entry
203

6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL

6-Methoxy-N2-methyl-2,3-pyridinediamine hydrochloride and dihydrochloride salt

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
90817-34-8 / 83732-72-3
EC
- / 280-622-9
Max concentration Product type 10/02/2014
Entry
204

DIHYDROXYINDOLINE

2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt (see note 17).

- Can cause allergic reaction - You have ever experienced any reaction afther colouring your hair - You have experienced a reaction to a temporary 'black henna' tattoo in the past

CAS
29539-03-5 - 138937-28-7
EC
- - 421-170-6
Max concentration Product type 27/05/2013
Entry
205

4-HYDROXYPROPYLAMINO-3-NITROPHENOL

1-Hydroxy-3-nitro-4-(3-hydroxypropylamino)benzene (see note 17)

(a) To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘blac…

CAS
92952-81-3
EC
406-305-9
Max concentration Product type 05/06/2014
Entry
206

HYDROXYETHYL-P-PHENYLENE-DIAMINE SULFATE

3-(2-Hydroxyethyl)-p- phenylenediammonium sulphate

(a) To be printed on the la­bel: The mixing ratio. “Hair colourants can cause severe allergic reac­tions. Read and follow instruc­tions. This product is not in­tended for use on persons under the age of 16. Temporary ‘b…

CAS
93841-25-9
EC
298-995-1
Product type 27/07/2020
Entry
207

DIHYDROXY-INDOLE

1H-Indole-5,6-diol

To be printed on the label: Hair colorants can cause severe allergic reactions.

CAS
3131-52-0
EC
412-130-9
Product type 09/09/2013
Entry
208

HC ORANGE NO. 2

1-(beta-Aminoethyl)amino-4-(beta-hydroxyethyl)oxy-2-nitrobenzene and its salts

Hair colorants can cause severe allergic reactions. Read and follow instructions. .

CAS
85765-48-6
EC
416-410-1
Max concentration Product type 24/07/2013
Entry
208

5-Amino-4-Chloro-o-Cresol HCl

5-Amino-4-chloro-2-methylphenol hydrochloride

To be printed on the label: Hair colorants can cause severe allergic reactions.

CAS
110102-85-7
EC
—
Product type 09/09/2013
Entry
209

6-Hydroxy-indole

1H-Indol-6-ol

To be printied on the label: Hair colorants can cause severe allergic reactions.

CAS
2380-86-1
EC
417-020-4
Product type 09/09/2013
Entry
21

QUININE

Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)- its salts

(a) Hair rinse-off products (b) Hair leave-on products

CAS
130-95-0
EC
205-003-2
Max concentration Product type 17/10/2010
Entry
210

ISATIN

1H-Indole-2,3-Dione

Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. D…

CAS
91-56-5
EC
202-077-8
Max concentration Product type 16/06/2014
Entry
211

2-AMINO-3-HYDROXYPYRIDINE

2-Aminopyridin-3-ol; 2-Amino-3-Hydroxypyridine

(a) To be printed on the la­bel: The mixing ratio. “Hair colourants can cause severe allergic reac­tions. Read and follow instruc­tions. This product is not in­tended for use on persons under the age of 16. Temporary ‘b…

CAS
16867-03-1
EC
240-886-8
Product type 27/07/2020
Entry
212

1-Acetoxy-2-Methylnaph-thalene

2-Methyl-1-naphthyl acetate

After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0% (When both 2-Methyl-1-Naphthol and 1-Acetoxy-2-Methylnaphthalene are present in a hair dye formulation, the maximum …

CAS
5697-02-9
EC
454-690-7
Product type 09/09/2013
Entry
213

2-Methyl-1-Naphthol

1-Hydroxy-2-methylnaphthalene

To be printed on the label: Hair colorants can cause severe allergic reactions.

CAS
7469-77-4
EC
231-265-2
Product type 09/09/2013
Entry
214

ACID YELLOW 1

Disodium 5,7-dinitro-8-oxido-2- naphthalenesulfonate CI 1036

To be printed on the label: Hair colorants can cause severe allergic reactions

CAS
846-70-8
EC
212-690-2
Max concentration Product type 09/09/2013
Entry
215

4-AMINO-3-NITROPHENOL

4-Amino-3-nitrophenol

(a) and (b) “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your ris…

CAS
610-81-1
EC
210-236-8
Max concentration Product type 05/06/2014
Entry
216

2,7-NAPHTHALENEDIOL

Naphthalene-2,7-diol

(a) To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘blac…

CAS
582-17-2
EC
209-478-7
Max concentration Product type 05/06/2014
Entry
217

M-AMINOPHENOL; M-AMINOPHENOL HCL; M-AMINOPHENOL SULFATE

m-Aminophenol and its salts

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
591-27-5/ 51-81-0 / 68239-81-6 /38171-54-9
EC
209-711-2 / 200-125-2 / 269-475-1
Product type 14/02/2014
Entry
218

2,6-DIHYDROXY-3,4-DIMETHYLPYRIDINE

6-Hydroxy-3,4- dimethyl-2-pyridone

To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black he…

CAS
84540-47-6
EC
283-141-2
Product type 05/06/2014
Entry
219

4-Hydroxypropylamino-3-nitrophenol

1-Hydroxy-3-nitro- 4-(3-hydroxypropy lamino)benzene

(a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “blac…

CAS
92952-81-3
EC
406-305-9
Max concentration Product type 04/10/2023
Entry
22

RESORCINOL

1,3-benzenediol

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
108-46-3
EC
203-585-2
Max concentration Product type 11/11/2022
Entry
220

HC Blue No 11

1-[(2′-Methoxye thyl)amino]-2-nitro- 4-[di-(2′-hydroxye thyl)amino]ben zene

— Do not use with nitro sating agents — Maximum nitrosamine content: 50 μg /kg — Keep in nitrite-free containers

CAS
23920-15-2
EC
459-980-7
Max concentration Product type 04/10/2023
Entry
221

Hydroxyethyl-2-Nitro-p-Toluidine

2-(4-Methyl-2-nitroanilino)ethanol

To be printed on the label: Hair colorants can use severe allergic reactions

CAS
100418-33-5
EC
408-090-7
Max concentration Product type 09/09/2013
Entry
222

2-HYDROXYETHYL PICRAMIC ACID

1-Hydroxy-2-beta-hydroxyethylamino-4,6-dinitrobenzene

(a) To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘blac…

CAS
99610-72-7
EC
412-520-9
Max concentration Product type CMR 05/06/2014
Entry
223

P-METHYLAMINOPHENOL

4-Methylaminophenol and its salts

Hair colourants can cause severe allergic reactions

CAS
150-75-4 - 55-55-0 - 1936-57-8
EC
205-768-2 - 200-237-1 - 217-706-1
Product type 30/05/2013
Entry
224

HC Violet No 2

1-Propanol, 3-[[4-[bis(2-hydroxyethyl)amino]-2-nitrophenyl]amino]

Can cause allergic reaction

CAS
104226-19-9
EC
410-910-3
Max concentration Product type 04/10/2023
Entry
225

HC BLUE NO. 12

1-(beta-Hydroxyethyl)amino-2-nitro-4-N-ethyl-N-(beta-hydroxyethyl)aminobenzene and its hydrocloride

(a) To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘blac…

CAS
104516-93-0 - 132885-85-9
EC
407-020-2
Max concentration Product type 05/06/2014
Entry
226

1,3-bis-(2,4-Diaminophenoxy)propane 1,3-bis-(2,4-Diaminophenoxy)propane HCl

4,4′-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt

(a) To be printed on the label: The mixing ratio. ‘imageHair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “…

CAS
81892-72-0 / 74918-21-1
EC
279-845-4 / 278-022-7
Max concentration Product type 04/10/2023
Entry
227

3-AMINO-2,4-DICHLOROPHENOL

3-Amino-2,4-dichlorophenol and its hydrochloride

(a) To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘blac…

CAS
61693-42-3 - 1693-43-4
EC
262-909-0
Max concentration Product type 05/06/2014
Entry
228

PHENYL METHYL PYRAZOLONE

3-Methyl-1-phenyl-5-pyrazolone

To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black he…

CAS
89-25-8
EC
201-891-0
Product type 05/06/2014
Entry
229

2-METHYL-5-HYDROXYETHYL AMINOPHENOL

5-[(2-hydroxyethyl)amino]-o-cresol

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
55302-96-0
EC
259-583-7
Product type 12/02/2014
Entry
230

HYDROXYBENZOMORPHOLINE

2,3-Dihydro-2H-1,4-benzoxazin-6-ol

To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black he…

CAS
26021-57-8
EC
247-415-5
Product type 29/11/2023
Entry
231

HC YELLOW NO. 10

1,5-Di-(beta-hydroxyethylamino)-2-nitro-4-chlorobenzene (see note 17)

- Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

CAS
109023-83-8
EC
416-940-3
Max concentration Product type 30/04/2014
Entry
234

HC VIOLET NO 1

Ethanol, 2-[(4-amino-2-methyl-5-nitrophenyl)amino]- and its salts

Hair colorants can cause severe allergic reactions. Read and follow instructions.

CAS
82576-75-8
EC
417-600-7
Max concentration Product type 24/07/2013
Entry
235

3-METHYLAMINO-4-NITROPHENOXYETHANOL

2-[3-(Methylamino)-4-nitrophenoxy]ethanol (see note 17)

- Do not use with nitrosating agents - Maximum nitrosamine content: 50 micrograme/Kg - Keep in nitrite-free containers

CAS
59820-63-2
EC
261-940-7
Max concentration Product type 24/07/2013
Entry
236

2-HYDROXYETHYLAMINO-5-NITROANISOLE

2-[(2-methoxy-4-nitrophenyl)amino]ethanol and its salts

- Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers

CAS
66095-81-6
EC
266-138-0
Max concentration Product type 24/07/2013
Entry
237

HC RED NO 13

2,2'-[(4-Amino-3-nitrophenyl)imino]bisethanol hydrochloride and its salts

Hair colourants can cause seere allergic reactions Read and follow instructions

CAS
29705-39-3 - 94158-13-1
EC
-- 303-083-4
Max concentration Product type 24/07/2013
Entry
238

1,5-NAPHTHALENEDIOL

Naphthalene-1,5-diol and its salts

Hair colourants can cause severe allergic reactions Read and follow instrctions

CAS
83-56-7
EC
201-487-4
Max concentration Product type 24/07/2013
Entry
239

HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL

Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) and its tetrahydro-chloride

Hair colourants can cause severe allergic reactions Read and follow instructions

CAS
128729-30-6 -- 128729-28-2
EC
416-320-2
Product type 25/07/2013
Entry
240

4-Nitro-o-Phenylenediamine

4-Nitro-1,2-phenylenediamine

To be printing on the label: Hair colorants can cause severe allergic reactions.

CAS
99-56-9
EC
202-766-3
Product type 09/09/2013
Entry
241

4-AMINO-2-HYDROXYTOLUENE

5-Amino-o-cresol

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions.Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black …

CAS
2835-95-2
EC
220-618-6
Product type 12/02/2014
Entry
242

2,4-DIAMINOPHENOXYETHANOL HCL

2,4-Diaminophenoxyethanol, its hydrochloride and its sulphate

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
70643-19-5 / 66422-95-5 / 70643-20-8
EC
- / 266-357-1 / 274-713-2
Product type 14/02/2014
Entry
243

2-METHYLRESORCINOL

1,3-benzenediol, 2-methyl

(a) To be printed on the la­bel: The mixing ratio. “Hair colourants can cause severe allergic reac­tions. Read and follow instruc­tions. This product is not in­tended for use on persons under the age of 16. Temporary ‘b…

CAS
608-25-3
EC
210-155-8
Max concentration Product type 27/07/2020
Entry
244

4-AMINO-M-CRESOL

4-Amino-m-cresol

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
2835-99-6
EC
220-621-2
Product type 12/02/2014

About this annex

Annex III covers substances that cosmetic products must not contain except under specific restrictions. These records often include warnings, conditions of use and concentration limits.

This section is especially useful for reviewing restricted substances, warning labels and product-type specific usage notes.