5-Amino-4-Chloro-o-Cresol HCl
5-Amino-4-chloro-2-methylphenol hydrochloride
5-Amino-4-Chloro-o-Cresol HCl is listed in Annex III and may only be used under the conditions shown in this record.
Chemical identity and properties
5-Amino-4-chloro-o-cresol hydrochloride
The Expert Panel for Cosmetic Ingredient Safety concluded that 5-Amino-4-Chloro-o-Cresol and 5-Amino-4-Chloro-o-Cresol HCl are safe for use as oxidative hair dye ingredients in the present practices of use and concentration described in this safety assessment. — Cosmetic Ingredient Review (CIR)
- IUPAC name
- 5-amino-4-chloro-2-methylphenol;hydrochloride
- Molecular formula
- C7H9Cl2NO
- Molecular weight
- 194.06 g/mol
- Exact mass
- 193.0061193 Da
- Topological polar surface area
- 46.3 Ų
- Hydrogen-bond donors
- 3
- Hydrogen-bond acceptors
- 2
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
8 more reported names
External database identifiers
- EPA DTXSID:DTXSID001021269
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Cosmetic Ingredient Review Conclusion: The Expert Panel for Cosmetic Ingredient Safety concluded that 5-Amino-4-Chloro-o-Cresol and 5-Amino-4-Chloro-o-Cresol HCl are safe for use as oxidative hair dye ingredients in the present practices of use and concentration described in this safety assessment. Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Link: CIR ingredient: 5-Amino-4-Chloro-o-Cresol HCl Source: Cosmetic Ingredient Review (CIR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Product type
Other restrictions
After mixing under oxidative conditions the maximum concentration to hair must not exceed 1,5% (calculated as hydrochloride).
Warnings
To be printed on the label:
Hair colorants can cause severe allergic reactions.
INCI glossary name
5-Amino-4-Chloro-o-Cresol HCl
Chemical name
5-Amino-4-chloro-2-methylphenol hydrochloride
Chemical / IUPAC name
5-Amino-4-chloro-2-methylphenol hydrochloride
Regulatory information
Key data
Inventory links for 5-Amino-4-Chloro-o-Cresol HCl
Related records for 5-Amino-4-Chloro-o-Cresol HCl
N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate
1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE
6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL
HYDROXYETHYL-P-PHENYLENE-DIAMINE SULFATE
What Annex III means for 5-Amino-4-Chloro-o-Cresol HCl
5-Amino-4-Chloro-o-Cresol HCl is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Confirm product type compatibility: Hair dye substance in oxidative hair dye products
- Include required warning statement on product label.
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record 5-Amino-4-Chloro-o-Cresol HCl
This page summarizes one Annex III record for 5-Amino-4-Chloro-o-Cresol HCl from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for 5-Amino-4-Chloro-o-Cresol HCl, but confirm any final regulatory decision against the current official annex wording and source files.
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