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Annex III Entry 21 17/10/2010

QUININE

Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)- its salts

QUININE is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (a) 0.5% (as quinine base) (b) 0.2% (as quinine base).

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: (a) 0.5% (as quinine base) (b) 0.2% (as quinine base)
Entry: 21

Record details

Maximum concentration

(a) 0.5% (as quinine base) (b) 0.2% (as quinine base)

Product type

Hair rinse-off products Hair leave-on products

INCI glossary name

QUININE

Chemical name

Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)- its salts

Chemical / IUPAC name

(8S,9R)-6'-Methoxycinchonan-9-ol

Regulatory information

Regulation

(EC) 2009/1223

Identified ingredients

Key data

CAS
130-95-0
EC
205-003-2
Annex
III
Entry number
21

Inventory links for QUININE

Inventory Restriction reference
Ref 37459

QUININE

CAS: 130-95-0
EC: 205-003-2

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 22
Nearby record in the same annex

RESORCINOL

CAS: 108-46-3
EC: 203-585-2
Annex III 18
Nearby record in the same annex

NITROMETHANE

CAS: 75-52-5
EC: 200-876-6
Annex III 17
Nearby record in the same annex

SODIUM NITRITE

CAS: 7632-00-0
EC: 231-555-9
Annex III 16
Nearby record in the same annex

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Nearby record in the same annex

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4

What Annex III means for QUININE

QUININE is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: (a) 0.5% (as quinine base) (b) 0.2% (as quinine base)
  • Confirm product type compatibility: (a) Hair rinse-off products (b) Hair leave-on products
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

QUININE is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 130-95-0 is the unique numerical identifier assigned to QUININE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (a) 0.5% (as quinine base) (b) 0.2% (as quinine base) applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record QUININE

This page summarizes one Annex III record for QUININE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for QUININE, but confirm any final regulatory decision against the current official annex wording and source files.

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