Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex III Entry 239 25/07/2013

HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL

Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) and its tetrahydro-chloride

HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL is listed in Annex III and may only be used under the conditions shown in this record.

Search similar Back to annex Compare
Restricted substance— Annex III, EU Regulation 1223/2009
Entry: 239

Chemical identity and properties

PubChem 2D chemical structure for CAS 128729-28-2
CAS 128729-28-2PubChem CID 21932462

Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride

IUPAC name
1,3-bis[4-amino-N-(2-hydroxyethyl)anilino]propan-2-ol;tetrahydrochloride
Molecular formula
C19H32Cl4N4O3
Molecular weight
506.3 g/mol
Exact mass
506.119902 Da
Topological polar surface area
119.0 Ų
Hydrogen-bond donors
9
Hydrogen-bond acceptors
7
Covalent units
5
Defined stereocentres
0

Also known as

Imexine OAXUNII-0K832J58E7Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) HCl0K832J58E72-Propanol, 1,3-bis((4-aminophenyl)(2-hydroxyethyl)amino)-, tetrahydrochloride1,3-Bis-((4-amino-phenyl)-(2-hydroxy-ethyl)-amino)-propan-2-ol, tetrahydrochloride2-Propanol, 1,3-bis((4-aminophenyl)(2-hydroxyethyl)amino)-, hydrochloride (1:4)RefChem:147262
9 more reported names
HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL [INCI]416-320-2Hydroxypropyl bis (N-Hydroxyethyl-p-phenylenediamine Hydrochloride) (>90%)2,2'-((2-Hydroxypropane-1,3-diyl)bis((4-aminophenyl)azanediyl))diethanol tetrahydrochloride1,3-bis[(4-Aminophenyl)(2-hydroxyethyl)amino]-2-propanol TetrahydrochlorideGATCALZBQPZIFW-UHFFFAOYSA-NHydroxypropyl bis (N-Hydroxyethyl-p-phenylenediamine Hydrochloride)1,3-Bis[(4-aminophenyl)(2-hydroxyethyl)amino]propan-2-ol--hydrogen chloride (1/4)2-Propanol,1,3-bis[(4-aminophenyl)(2-hydroxyethyl)amino]-, tetrahydrochloride
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match21932462

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P272, P273, P280, P302+P352, P305+P354+P338, P317, P321, P332+P317, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 128729-30-6
CAS 128729-30-6PubChem CID 9885240

1,3-Bis((4-aminophenyl)-(2-hydroxyethyl)-amino)-propan-2-ol

IUPAC name
1,3-bis[4-amino-N-(2-hydroxyethyl)anilino]propan-2-ol
Molecular formula
C19H28N4O3
Molecular weight
360.5 g/mol
Exact mass
360.21614077 Da
XLogP3
0.5
Topological polar surface area
119.0 Ų
Hydrogen-bond donors
5
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
0

Also known as

UNII-632K3X0904632K3X09042-Propanol, 1,3-bis((4-aminophenyl)(2-hydroxyethyl)amino)-1,3-Bis(N-(4-aminophenyl)-N-(2-hydroxyethyl)amino)-2-propanol1,3-bis[(4-aminophenyl)(2-hydroxyethyl)amino]propan-2-ol2-aPropanol, 1,a3-abis[(4-aaminophenyl)a(2-ahydroxyethyl)aamino]a-
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match9885240

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Product type

Hair dye substance in oxidative hair dye products

Other restrictions

After mixing under oxidative conditions the maximumconcentration applied to hair must not exceed 0.4% (as tetrahydro-chloride)

Warnings

Hair colourants can cause severe allergic reactions
Read and follow instructions

INCI glossary name

HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL

Chemical name

Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) and its tetrahydro-chloride

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
128729-30-6 -- 128729-28-2
EC
416-320-2
Annex
III
Entry number
239

Inventory links for HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL

Annex III 16
Shared product type

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Shared product type

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8

What Annex III means for HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL

HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm product type compatibility: Hair dye substance in oxidative hair dye products
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 128729-30-6 -- 128729-28-2 is the unique numerical identifier assigned to HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex III record HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL

This page summarizes one Annex III record for HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex III and compare regulatory conditions across substances in this annex.

Open Annex III