HC YELLOW NO. 10
1,5-Di-(beta-hydroxyethylamino)-2-nitro-4-chlorobenzene (see note 17)
HC YELLOW NO. 10 is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 0.1%.
Chemical identity and properties
HC Yellow no. 10
- IUPAC name
- 2-[4-chloro-5-(2-hydroxyethylamino)-2-nitroanilino]ethanol
- Molecular formula
- C10H14ClN3O4
- Molecular weight
- 275.69 g/mol
- Exact mass
- 275.0672836 Da
- XLogP3
- 1.5
- Topological polar surface area
- 110.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 6
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
9 more reported names
External database identifiers
- EPA DTXSID:DTXSID40148798
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Maximum concentration
0.1%
Other restrictions
- Do not use with nitrosating agents
- Maximum nitrosamine content: 50 microgram/kg
- Keep in nitrite-free containers
INCI glossary name
HC YELLOW NO. 10
Chemical name
1,5-Di-(beta-hydroxyethylamino)-2-nitro-4-chlorobenzene (see note 17)
Chemical / IUPAC name
1,5-Di-(beta-hydroxyethylamino)-2-nitro-4-chlorobenzene
Regulatory information
SCCS opinions
- Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products
- Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004
- Opinion on Personal Use of Hair Dyes and Cancer Risk
- Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk
- Assessment Strategies for Hair Dyes
- Opinion on 1,5-Di(beta-hydroxyethylamino)-2-nitro-4-chlorobenzene
- Opinion on HC Yellow No. 10
Identified ingredients
Key data
Inventory links for HC YELLOW NO. 10
Related records for HC YELLOW NO. 10
CI 19140 / ACID YELLOW 23
ACID BLUE 9
6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL
What Annex III means for HC YELLOW NO. 10
HC YELLOW NO. 10 is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Ensure formulation concentration does not exceed: 0.1%
- Confirm product type compatibility: Hair dye substance in non-oxidative hair dyes products
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record HC YELLOW NO. 10
This page summarizes one Annex III record for HC YELLOW NO. 10 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for HC YELLOW NO. 10, but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
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