CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex III Entry 200 27/07/2020

TETRAAMINOPYRIMIDINE SULFATE

2,4,5,6-Tetraaminopyrimidine sulphate

TETRAAMINOPYRIMIDINE SULFATE is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (b) 3,4% (calculated as sulphate).

Search similar Back to annex Compare
Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: (b) 3,4% (calculated as sulphate)
Entry: 200

Record details

Maximum concentration

(b) 3,4% (calculated as sulphate)

Product type

Hair dye substance in oxidative hair dye products Hair dye substance in non-oxidative hair dye products Products in­tended for col­ouring eyelashes

Other restrictions

(a) (c) After mixing under oxidative condit­ions the maximum concentration ap­plied to hair or eye­lashes must not ex­ceed 3,4 % (calcu­lated as sulfate)
(c) Professional use

Warnings

(a) To be printed on the la­bel: The mixing ratio. “Hair colourants can cause severe allergic reac­tions. Read and follow instruc­tions. This product is not in­tended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irri­tated and damaged scalp, — you have ever experi­enced any reaction after colouring your hair, — you have experienced a reaction to a tempor­ary ‘black henna’ tattoo in the past.”

(c) As from 3 March 2018, to be printed on the la­bel: The mixing ratio. “This product can cause severe allergic reactions. Read and follow instruc­tions. This product is not in­tended for use on persons under the age of 16. Tem­porary ‘black henna’ tattoos may increase the risk of al­lergy. Eyelashes shall not be co­loured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp, — has experienced any re­action after colouring hair or eyelashes, — has experienced a reac­tion to a temporary ‘black henna’ tattoo in the past.

For professional use only. Rinse eyes immediately if product comes into contact with them”.

INCI glossary name

TETRAAMINOPYRIMIDINE SULFATE

Chemical name

2,4,5,6-Tetraaminopyrimidine sulphate

Chemical / IUPAC name

2,4,5,6-Tetraaminopyrimidine sulphate

Regulatory information

Regulation

(EU) 2017/237

Key data

CAS
5392-28-9
EC
226-393-0
Annex
III
Entry number
200

Inventory links for TETRAAMINOPYRIMIDINE SULFATE

Inventory Restriction reference
Ref 34213

HC VIOLET NO. 2

CAS: 104226-19-9
EC: 410-910-3
Annex III 16
Shared product type

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Shared product type

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 190
Shared product type

ACID BLUE 9

CAS: 3844-45-9 - 2650-18-2 - 68921-42-6
EC: 223-339-8 - 220-168-0 - 272-939-6
Annex III 191
Shared product type

CURRY RED

CAS: 25956-17-6
EC: 247-368-0
Annex III 192
Shared product type

ACID RED 18

CAS: 2611-82-7 - 12227-64-4
EC: 220-036-2 - 235-438-3
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8
Annex III 195
Shared product type

ACID BLUE 62

CAS: 4368-56-3
EC: 224-460-9

What Annex III means for TETRAAMINOPYRIMIDINE SULFATE

TETRAAMINOPYRIMIDINE SULFATE is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: (b) 3,4% (calculated as sulphate)
  • Confirm product type compatibility: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products (c) Products in­tended for col­ouring eyelashes
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

TETRAAMINOPYRIMIDINE SULFATE is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 5392-28-9 is the unique numerical identifier assigned to TETRAAMINOPYRIMIDINE SULFATE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (b) 3,4% (calculated as sulphate) applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex III record TETRAAMINOPYRIMIDINE SULFATE

This page summarizes one Annex III record for TETRAAMINOPYRIMIDINE SULFATE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for TETRAAMINOPYRIMIDINE SULFATE, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect TETRAAMINOPYRIMIDINE SULFATE and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare TETRAAMINOPYRIMIDINE SULFATE side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex III and compare regulatory conditions across substances in this annex.

Open Annex III