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Annex III Entry 203 10/02/2014

6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL

6-Methoxy-N2-methyl-2,3-pyridinediamine hydrochloride and dihydrochloride salt

6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (b) 0.68% as free base (1.0% as dihydrochloride).

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: (b) 0.68% as free base (1.0% as dihydrochloride)
Entry: 203

Record details

Maximum concentration

(b) 0.68% as free base (1.0% as dihydrochloride)

Product type

Hair dye substance in oxidative hair dye products Hair dye substance in non-oxidative hair dye products Products intended for colouring eyelashes

Other restrictions

For (a) and (c): After mixing under oxidative conditions the maximum use concentration applied to hair or eyeslashes must not exceed 0.68% calculated as free base (1.0% as dihydrochloride).
For (a) (b) and (c):
- Do not use with nitrosating agents
- Maximum nitrosamine content: 50 microgram/kg
- Keep in nitrite-free containers
(c) For professional use only

Warnings

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16.
Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past
(b) Can cause allergic reaction
(c) To be printed on the label: The mixing ratio. “For professional use only. This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16.Temporary ‘black henna’ tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp, — has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary ‘black henna’ tattoo in the past. Rinse eyes immediately if product comes into contact with them.” ’

INCI glossary name

6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL

Chemical name

6-Methoxy-N2-methyl-2,3-pyridinediamine hydrochloride and dihydrochloride salt

Chemical / IUPAC name

6-Methoxy-2-methylamino-3-aminopyridine HCl

Regulatory information

Regulation

(EC) 2013/1197

SCCS opinions

Identified ingredients

Key data

CAS
90817-34-8 / 83732-72-3
EC
- / 280-622-9
Annex
III
Entry number
203

Inventory links for 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL

Annex III 16
Shared product type

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Shared product type

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 190
Shared product type

ACID BLUE 9

CAS: 3844-45-9 - 2650-18-2 - 68921-42-6
EC: 223-339-8 - 220-168-0 - 272-939-6
Annex III 191
Shared product type

CURRY RED

CAS: 25956-17-6
EC: 247-368-0
Annex III 192
Shared product type

ACID RED 18

CAS: 2611-82-7 - 12227-64-4
EC: 220-036-2 - 235-438-3
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8
Annex III 195
Shared product type

ACID BLUE 62

CAS: 4368-56-3
EC: 224-460-9

What Annex III means for 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL

6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: (b) 0.68% as free base (1.0% as dihydrochloride)
  • Confirm product type compatibility: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products (c) Products intended for colouring eyelashes
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 90817-34-8 / 83732-72-3 is the unique numerical identifier assigned to 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (b) 0.68% as free base (1.0% as dihydrochloride) applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

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Source note for Annex III record 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL

This page summarizes one Annex III record for 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL, but confirm any final regulatory decision against the current official annex wording and source files.

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