ISATIN
1H-Indole-2,3-Dione
ISATIN is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 1.6%.
Chemical identity and properties
Isatin
Isatin is an indoledione that is the 2,3-diketo derivative of indole. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and a plant metabolite. — ChEBI
- IUPAC name
- 1H-indole-2,3-dione
- Molecular formula
- C8H5NO2
- Molecular weight
- 147.13 g/mol
- Exact mass
- 147.032028402 Da
- XLogP3
- 0.8
- Topological polar surface area
- 46.2 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:27539
- ChEMBL:CHEMBL326294
- EPA DTXSID:DTXSID3038694
- PubMed:30926317
- PubMed:24636345
- PubMed:24316276
- PubMed:24246760
- PubMed:23295225
- PubMed:23247010
- PubMed:23103534
- PubMed:23044749
- PubMed:23028517
- PubMed:23011183
- PubMed:22969614
- PubMed:22920713
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Maximum concentration
1.6%
Warnings
Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if:
— you have a rash on your face or sensitive, irritated and damaged scalp,
— you have ever experienced any reaction after colouring your hair,
— you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.’
INCI glossary name
ISATIN
Chemical name
1H-Indole-2,3-Dione
Chemical / IUPAC name
1H-Indole-2,3-Dione
Regulatory information
Key data
Inventory links for ISATIN
Related records for ISATIN
CI 19140 / ACID YELLOW 23
ACID BLUE 9
6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL
What Annex III means for ISATIN
ISATIN is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Ensure formulation concentration does not exceed: 1.6%
- Confirm product type compatibility: Hair dye substance in non-oxidative hair dye products
- Include required warning statement on product label.
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record ISATIN
This page summarizes one Annex III record for ISATIN from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for ISATIN, but confirm any final regulatory decision against the current official annex wording and source files.
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