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Annex III Entry 8a 03/03/2015

p-Phenylenediamine and its salts

p-Phenylenediamine and its salts is listed in Annex III and may only be used under the conditions shown in this record.

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Restricted substance— Annex III, EU Regulation 1223/2009
Entry: 8a

Chemical identity and properties

PubChem 2D chemical structure for CAS 106-50-3
CAS 106-50-3PubChem CID 7814

P-Phenylenediamine

1,4-phenylenediamine is a phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus. It has a role as a reagent, a dye, an allergen and a hapten. — ChEBI

IUPAC name
benzene-1,4-diamine
Molecular formula
C6H8N2
Molecular weight
108.14 g/mol
Exact mass
108.068748264 Da
XLogP3
-0.3
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

1,4-BENZENEDIAMINE1,4-Diaminobenzene1,4-Phenylenediamine4-Aminoanilinepara-phenylenediaminep-Aminoanilinep-DiaminobenzeneOrsin
16 more reported names
ParaphenylenediamineUrsol D4-Phenylenediaminep-BenzenediamineFouramine DFutramine DBenzofur DDeveloper PFFourrine DFur YellowSantoflex ICSantoflex LCDurafur Black RPelagol DTertral DPelagol DR
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:51403

1,4-phenylenediamine

A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.

Formula
C6H8N2
Average mass
108.144 g/mol
Monoisotopic mass
108.06875 Da
Formal charge
0
  • phenylenediamine — is a (CHEBI:51402)
  • dye — has role (CHEBI:37958)
  • reagent — has role (CHEBI:33893)
  • allergen — has role (CHEBI:50904)
  • hapten — has role (CHEBI:59174)
  • dye — has role (CHEBI:37958)
  • reagent — has role (CHEBI:33893)
  • allergen — has role (CHEBI:50904)
  • hapten — has role (CHEBI:59174)
  • phenylenediamine — is a (CHEBI:51402)
Additional curated names
benzene-1,4-diamine1,4-Benzenediamine1,4-diaminobenzene4-Aminoaniline4-phenylenediaminepara-phenylenediamineparaphenylene-diamineparaphenylenediaminep-DiaminobenzenePPDpPDAPPDAp-Phenylenediaminep-phenylenediamine base
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2024-03-05. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7814

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P321, P330, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301+H311+H331 (43.2%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H301 (99.7%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (99.7%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H317 (99.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (99.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (99.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H370 (38.9%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H400 (98.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (99.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P321, P330, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 597 reports by companies from 32 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P319, P321, P330, P333+P317, P337+P317, P342+P316, P362+P364, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P319, P321, P330, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Environmental Bioconcentration: An estimated BCF value of 0.3 was calculated for 1,4-benzenediamine(SRC), using a measured log Kow of -0.3(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). An experimental BCF value of 450 was measured for algae exposed to 1,4-diaminobenzene dihydrochloride for 24 hours(4). An experimental BCF value of 6 was measured for fish (golden ide) exposed to 1,4-diaminobenzene dihydrochloride for 3 days(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 16(SRC), determined from a measured log Kow of -0.30(2), and a recommended regression-derived equation(3), indicates that 1,4-benzenediamine is expected to have high mobility in soil(SRC); however it may form covalent bonds to humic material which would limit movement through soil(4). Volatilization of 1,4-benzenediamine is not expected from moist soil surfaces(SRC) given an estimated Henry's Law constant of 6.7X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(5). Volatilization of 1,4-benzenediamine from dry soil surfaces is not expected(SRC) based on an extrapolated vapor pressure of 0.005 mm Hg(SRC) at 25 °C(6). Biodegradation is expected to occur slowly in soils based on standard biodegradability tests conducted with activated sludge(7-11). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 16(SRC), determined from a measured log Kow of -0.30(2), and a recommended regression-derived equation(3), indicates that 1,4-benzenediamine is not expected to adsorb to suspended solids and sediment in water(SRC). 1,4-benzenediamine is not expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 6.7X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Degradation of 1,4-benzenediamine by photochemically produced peroxy radicals will be an important environmental fate process in surface waters(5,SRC). The half-life of this reaction is estimated as 1 day for a solution concentration of 1X10-9 M of peroxy radicals and an estimated rate constant of 1X10+4 L/mol-s(5). According to a classification scheme(6), an estimated BCF value of 0.3(3,SRC), from a measured log Kow of -0.3(2,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Biodegradation in aquatic environments is not expected to be an important environmental fate process(SRC). A 0% theoretical oxygen demand was observed for 1,4-benzenediamine in a Warbu Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,4-benzenediamine, which has an extrapolated vapor pressure of 0.005 mm Hg at 25 °C(2,SRC), is expected to exist primarily as a vapor in the ambient atmosphere. Vapor-phase 1,4-benzenediamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 2 hours(3,SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Link: CIR ingredient: p-Phenylenediamine Source: Cosmetic Ingredient Review (CIR)
  • Uses: p-Phenylenediamine is primarily used as a dye intermediate and as a dye (e.g., hair dyes and dyes used for dyeing furs), as well as a photographic developing agent and a chemical intermediate. p-Phenylenediamine is also used as a vulcanization accelerator and as an antioxidant in rubber compounds. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used to dye hair and fur; also used to develop photographs and to synthesize other organic compounds; [ACGIH] Occupational asthma reported in fur dyers; [Malo] Allergic contact dermatitis in hairdressers, mechanics, printers, and textile workers; [Marks] Used to dye leather; [PMID 21938525] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Leather Tanning and Processing [Category: Industry]; Photographic Processing [Category: Other]; Fur Dressing and Dyeing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry]; Dressing Hair [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Dyeing furs; also in photochemical measurements, accelerating vulcanization; manuf azo dyes. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: CHEM INT FOR DYES (EG, DIRECT BLACK 19, 78 & 80); OXIDN BASE 10 & DEVELOPER 13 FOR DYES; CHEM INT FOR ARAMID FIBERS (USED IN TIRE CORD); CHEM INT FOR N,N'-DISUBSTITUTED-P-PHENYLENEDIAMINES; COMPONENT OF GASOLINE ANTIOXIDANTS. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used as an intermediate for the manufacture of diisocyanates for polyurethane Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Substance listed with specific concentration in tattoo ink and/or permanent make up according to EU Commission Regulation 2020/2081. The concentration limit (by weight) is 0.0005%. Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 16245-77-5
CAS 16245-77-5PubChem CID 27769

1,4-Benzenediamine sulfate

IUPAC name
benzene-1,4-diamine;sulfuric acid
Molecular formula
C6H10N2O4S
Molecular weight
206.22 g/mol
Exact mass
206.03612798 Da
Topological polar surface area
135.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Covalent units
2
Defined stereocentres
0

Also known as

p-Phenylenediamine sulfate1,4-Benzenediamine, sulfate (1:1)1,4-Benzenediamine, sulfateUNII-S7IGM30961HSDB 6256EINECS 240-357-1COVASTYLE PPDSCOLOREX PPDS
16 more reported names
1,4-Benzenediamine sulfate (1:1)1,4-BENZENEDIAMINE SULFATE [HSDB]pPhenylenediamine sulfateRefChem:73044Benzene1,4diammonium sulphateP-PHENYLENEDIAMINE SULFATE [INCI]240-357-11,4-Phenylenediamine Sulfate1,4-Diaminobenzene SulfateBenzene-1,4-diammonium sulphateS7IGM30961UFPKLWVNKAMAPE-UHFFFAOYSA-NBS-42135DB-043524DB-071285P0175
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 624-18-0
CAS 624-18-0PubChem CID 12205

1,4-Diaminobenzene dihydrochloride

1,4-phenylenediamine dihydrochloride appears as white to slightly reddish crystals or gray powder. (NTP, 1992) — CAMEO Chemicals

IUPAC name
benzene-1,4-diamine;dihydrochloride
Molecular formula
C6H10Cl2N2
Molecular weight
181.06 g/mol
Exact mass
180.0221037 Da
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

p-Phenylenediamine dihydrochloride1,4-Phenylenediamine dihydrochloridebenzene-1,4-diamine dihydrochlorideFourrine DSPelagol Grey CDDurafur Black RCFourrine 641,4-Benzenediamine dihydrochloride
16 more reported names
p-PD HClp-Phenylenediamine HClPelagol CD1,4-Benzenediamine, dihydrochloridep-Pda HClOxidation Base 10AC.I. Oxidation Base 10A4-Aminoaniline dihydrochloridep-Benzenediamine dihydrochloridep-Diaminobenzene dihydrochlorideCI Oxidation Base 10ANCI-C03930p-Phenylenediamine, dihydrochloridep-Aminoaniline dihydrochlorideCCRIS 510Phenylenediamine dihydrochloride
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Product type

Hair dye substance in oxidative hair dye products

Other restrictions

(a) General use
(b) Professional use For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2 % calculated as free base

Warnings

(a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. Contains phenylenediamines. Do not use to dye eyelashes or eyebrows.’
(b) To be printed on the label: The mixing ratio. ‘For professional use only. Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. Contains phenylenediamines. Wear suitable gloves.’

Chemical name

p-Phenylenediamine and its salts

Chemical / IUPAC name

p-Phenylenediamine; p-Phenylenediamine HCl; p-Phenylenediamine Sulphate

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

Key data

CAS
106-50-3 / 624-18-0 / 16245-77-5
EC
203-404-7 / 210-834-9 / 240-357-1
Annex
III
Entry number
8a

Inventory links for p-Phenylenediamine and its salts

Annex III 16
Shared product type

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Shared product type

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8

What Annex III means for p-Phenylenediamine and its salts

p-Phenylenediamine and its salts is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 3 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm product type compatibility: Hair dye substance in oxidative hair dye products
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

p-Phenylenediamine and its salts is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 106-50-3 / 624-18-0 / 16245-77-5 is the unique numerical identifier assigned to p-Phenylenediamine and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record p-Phenylenediamine and its salts

This page summarizes one Annex III record for p-Phenylenediamine and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for p-Phenylenediamine and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

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