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Annex III Entry 198 09/09/2013

N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate

2,2′-[(4-Aminophenyl))imino]bis (ethanol) sulphate; N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate

N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate is listed in Annex III and may only be used under the conditions shown in this record.

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Restricted substance— Annex III, EU Regulation 1223/2009
Entry: 198

Record details

Product type

Hair dye substance in oxidative hair dye products

Other restrictions

After mixing under oxidative conditionsthe maximum concentration applied to hair must not exceed 2,5% (calculated as sulphate)
- Do not use with nitrosating agents
- Maximum nitrosamine content: 50 microgram/Kg

Warnings

To be printed on the label:
Hair colorants can cause severe allergic reactions

INCI glossary name

N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate

Chemical name

2,2′-[(4-Aminophenyl))imino]bis (ethanol) sulphate; N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate

Regulatory information

Regulation

(EU) 2013/658

Key data

CAS
54381-16-
EC
259-134-5
Annex
III
Entry number
198

Inventory links for N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate

Annex III 16
Shared product type

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Shared product type

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8

What Annex III means for N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate

N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm product type compatibility: Hair dye substance in oxidative hair dye products
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 54381-16- is the unique numerical identifier assigned to N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate

This page summarizes one Annex III record for N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for N,N-bis(2-Hydroxyethyl)- p-Phenylenediamine Sulfate, but confirm any final regulatory decision against the current official annex wording and source files.

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