What is CAS 120-51-4 for Benzyl benzoate?

CAS 120-51-4 is the unique numerical identifier assigned to Benzyl benzoate by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex III Entry 85 Allergen 17/10/2010

Benzyl benzoate

Q: How do I check if my product formula contains Benzyl benzoate?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Benzyl benzoate is listed in Annex III and may only be used under the conditions shown in this record.

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Restricted substance— Annex III, EU Regulation 1223/2009

Entry: 85

Allergen

Declared fragrance allergen

This substance is on the EU list of fragrance allergens that must be named individually in the ingredient list, rather than being covered by the word "parfum", once it exceeds 0.001% in a leave-on product or 0.01% in a rinse-off product.

Declaration is a labelling duty under Article 19, not a restriction on use. See the allergen record

Chemical identity and properties

PubChem 2D chemical structure for CAS 120-51-4

CAS 120-51-4PubChem CID 2345

Benzyl Benzoate

Benzyl benzoate is a benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. It has a role as an acaricide, a scabicide and a plant metabolite. It is a benzoate ester and a benzyl ester. It is functionally related to a benzoic acid. — ChEBI

IUPAC name: benzyl benzoate

Molecular formula: C14H12O2
Molecular weight: 212.24 g/mol
Exact mass: 212.083729621 Da
XLogP3: 4.0
Topological polar surface area: 26.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

AscabiolBenylateBenzoic acid, phenylmethyl esterPhenylmethyl benzoateBenzoic acid, benzyl esterScobenolAscabinNovoscabin

16 more reported names

ScabiozonBenzyl phenylformateBenzyletsColebenzPeruscabinScabancaScabagenScabitoxVanzoateVenzonateScabideBenzyl benzenecarboxylateAntiscabiosumBenzylis benzoasBenzyl alcohol benzoic esterPeruscabina

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:41237
ChEMBL:CHEMBL1239
EPA DTXSID:DTXSID8029153
PubMed:29540657
PubMed:27965148
PubMed:27270453
PubMed:26795242
PubMed:23001898
PubMed:22980009
PubMed:22954530
PubMed:22833176
PubMed:22799103
PubMed:22721474
PubMed:22701601
PubMed:22619691

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match2345

Attributed physical-property, hazard, environmental and use annotations.

Autoignition Temperature: 896 °F (480 °C) Source: Hazardous Substances Data Bank (HSDB)
Autoignition Temperature: 480 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Boiling Point: 323.5 °C Source: DrugBank
Boiling Point: 321.3 °C Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: BP: 323-324 °C Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: 323.00 to 324.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
Boiling Point: 324 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Boiling Point: 323-324 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Boiling Point: 324 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy

Color/Form: Leaflets or oily liquid Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Water-white liquid Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Colorless, oily liquid Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Clear, colorless liquid Source: Hazardous Substances Data Bank (HSDB)

Density: 1.1121 g/cu cm at 25 °C Source: Hazardous Substances Data Bank (HSDB)
Density: Relative density (water = 1): 1.1 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Density: 1.113-1.121 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Density: 1.116 @25 °C Source: PAC Chemical Database, U.S. Department of Energy

Flash Point: 148 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Flash Point: 158 °C (316 °F) - closed cup Source: Hazardous Substances Data Bank (HSDB)
Flash Point: 298 °F (148 °C) - closed cup Source: Hazardous Substances Data Bank (HSDB)
Flash Point: 148 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

LogP: 3.97 Source: DrugBank
LogP: log Kow = 3.97 Source: Hazardous Substances Data Bank (HSDB)
LogP: 3.7 Source: Human Metabolome Database (HMDB)
LogP: 3.97 Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Melting Point: 21 °C Source: DrugBank
Melting Point: 19 °C Source: Hazardous Substances Data Bank (HSDB)
Melting Point: 21 °C Source: Human Metabolome Database (HMDB)
Melting Point: 21 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Odor: Light, balsamic odor reminiscent of almond Source: Hazardous Substances Data Bank (HSDB)
Odor: Faint, pleasant, aromatic odor Source: Hazardous Substances Data Bank (HSDB)

Physical Description: CBI; Other Solid; Dry Powder; Other Solid; Liquid Source: EPA Chemical Data Reporting (CDR)
Physical Description: Colorless liquid or white solid; [ICSC] Not miscible or difficult to mix in water; [MSDSonline] Pleasant odor; Slightly volatile in steam and insoluble in water; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: Solid Source: Human Metabolome Database (HMDB)
Physical Description: COLOURLESS LIQUID OR WHITE SOLID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Physical Description: leaflets or oily liquid with a faint, sweet, balsamic odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Refractive Index: Index of refraction: 1.5680 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
Refractive Index: Index of refraction: 1.5681 at 21 °C/D Source: Hazardous Substances Data Bank (HSDB)
Refractive Index: 1.566-1.571 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Solubility: 15.4 mg/L Source: DrugBank
Solubility: Insoluble in water Source: Hazardous Substances Data Bank (HSDB)
Solubility: Insoluble in glycerol; miscible with alcohol, chloroform, ether, oils Source: Hazardous Substances Data Bank (HSDB)
Solubility: Soluble in ethanol, ethyl ether, acetone, benzene, methanol, chloroform Source: Hazardous Substances Data Bank (HSDB)
Solubility: 1.98e-02 g/L Source: Human Metabolome Database (HMDB)
Solubility: Solubility in water: none Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Solubility: insoluble in water; soluble in organic solvents, oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Solubility: miscible at room temperature (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Vapor Pressure: 0.000224 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: 0.000224 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
Vapor Pressure: 0.00022 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy

Viscosity: 8.292 cP at 25 °C Source: Hazardous Substances Data Bank (HSDB)

pH: Solution in alcohol practically neutral to moistened litmus paper Source: Hazardous Substances Data Bank (HSDB)

Exposure Routes: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H400 (21.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411 (99.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 2822 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: NITE-CMC
GHS Hazard Statements: H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
Precautionary Statement Codes: P260, P264, P270, P273, P308+P316, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral] Source: NITE-CMC
Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: NITE-CMC

NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)

Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
Toxicity Summary: IDENTIFICATION AND USE: Benzyl benzoate is a liquid. It is used as solvent of cellulose acetate, nitrocellulose and artificial musk, substitute for camphor in celluloid and plastic pyroxylin compounds, perfume fixative, in confectionary and chewing gum flavors. As an insecticide/miticide, it was used to control dust mites in carpets, mattresses, upholstery, and on furniture. Benzyl benzoate is used as an alternative agent for the topical treatment of scabies and also has been used for the topical treatment of pediculosis (lice infestation). It is also used in veterinary medicine as acaricide and pediculicide, but is contraindicated in cats. It was used in the Vietnam War to eradicate and repel certain ticks and mites. HUMAN STUDIES: Direct contact may cause skin irritation. Liquid is irritating to eyes on direct contact, but no damage has been reported. There was no evidence of adverse effects on pregnancy outcome due to topical benzyl benzoate lotion. Benzyl benzoate gave estrogenic responses in a human breast cancer cell line in culture. ANIMAL STUDIES: 13-week study in rats demonstrated decreased body weight gain and mortality at 800 mg/kg/day. Neurotoxicity signs noted such as Source: Hazardous Substances Data Bank (HSDB)

Environmental Bioconcentration: An estimated BCF of 190 was calculated in fish for benzyl benzoate(SRC), using a log Kow of 3.97(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC). Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2500(SRC), determined from a structure estimation method(2), indicates that benzyl benzoate is expected to have slight mobility in soil(SRC). Volatilization of benzyl benzoate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.3X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Benzyl benzoate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 2.24X10-4 mm Hg at 25 °C(3). Utilizing the Japanese MITI test, 90% of the Theoretical BOD was reached in 4 weeks(4) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2500(SRC), determined from a structure estimation method(2), indicates that benzyl benzoate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.3X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 190(SRC), from its log Kow of 3.97(5) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is high(SRC). Hydrolysis is not expected to be an important environmental fate process as suggested by estimated acid-base hydrolysis half-lives of 1.7 years and 63 days at pH 7 and pH 8, respectively(1). Utilizing the Japanese MITI test, 90% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), benzyl benzoate, which has a vapor pressure of 2.25X10-4 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase benzyl benzoate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 55 hrs(SRC), calculated from its rate constant of 7.0X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase benzyl benzoate may be removed from the air by wet and dry deposition(SRC). Benzyl benzoate contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Consumer Uses: Fragrance; Plasticizer; Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)

Industry Uses: Flavoring and nutrient; Solvent; Not Known or Reasonably Ascertainable; Fixing agent (mordant); Fragrance Source: EPA Chemical Data Reporting (CDR)

Cosmetic Ingredient Review Link: CIR ingredient: Benzyl Benzoate Source: Cosmetic Ingredient Review (CIR)
Sources/Uses: Used in plastic pyroxylin compounds, flavors, perfumes, plasticizers, dye carriers, antispasmodic drugs, insect repellants, scabicides , and pediculicides; [HSDB] Used as a dye carrier and a solvent for cellulose derivatives, plasticizers, and perfume fixatives; It is the main constituent in Peru balsam; Used in drugs for asthma; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: For benzyl benzoate (USEPA/OPP Pesticide Code: 009501) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: As solvent of cellulose acetate, nitrocellulose and artificual musk; substitute for camphor in celluloid and plastic pyroxylin compounds; perfume fixative; in confectionary and chewing gum flavors. Source: Hazardous Substances Data Bank (HSDB)
Uses: Fixative and solvent for musk in perfumes and flavors; medicine (external); plasticizer for nitrocellulose and cellulose acetate, miticide. Source: Hazardous Substances Data Bank (HSDB)
Uses: Reported uses (ppm):; Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association, 1994) [Table#818] Source: Hazardous Substances Data Bank (HSDB)
Uses: For more Uses (Complete) data for Benzyl benzoate (8 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Uses: Use (kg; approx.) in Germany (2009): >750; Consumption (g per capita; approx.) in Germany (2009): 0.00916; Excretion rate: 1; Calculated removal (%): 94.9 Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Other restrictions

The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)g when its concentration exceeds:
- 0.001% in leave-on products
- 0.01% in rinse-off products

INCI glossary name

Benzyl benzoate

Chemical name

Benzyl benzoate

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

BENZYL BENZOATE

EU Fragrance Allergen

This substance is linked to an EU fragrance-allergen reference. Check the current Annex III entry for the declaration threshold and any additional conditions.

BENZYL BENZOATE

Key data

CAS

120-51-4

204-402-9

Annex

III

Entry number

Inventory links for Benzyl benzoate

Inventory Restriction reference

Ref 32154

BENZYL BENZOATE

CAS: 120-51-4

EC: 204-402-9

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 84