ANISe ALCOHOL
4-Methoxybenzyl alcohol
ANISe ALCOHOL is listed in Annex III and may only be used under the conditions shown in this record.
This substance is on the EU list of fragrance allergens that must be named individually in the ingredient list, rather than being covered by the word "parfum", once it exceeds 0.001% in a leave-on product or 0.01% in a rinse-off product.
Declaration is a labelling duty under Article 19, not a restriction on use. See the allergen record
Chemical identity and properties
4-Methoxybenzyl alcohol
4-Methoxybenzyl alcohol is a member of benzyl alcohols. — ChEBI
- IUPAC name
- (4-methoxyphenyl)methanol
- Molecular formula
- C8H10O2
- Molecular weight
- 138.16 g/mol
- Exact mass
- 138.068079557 Da
- XLogP3
- 1.1
- Topological polar surface area
- 29.5 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:193647
- ChEMBL:CHEMBL294431
- EPA DTXSID:DTXSID6044357
- PubMed:22708725
- PubMed:22421904
- PubMed:22271643
- PubMed:22036971
- PubMed:22033097
- PubMed:21375505
- PubMed:21270975
- PubMed:20828316
- PubMed:20495907
- PubMed:20074740
- PubMed:19901994
- PubMed:19574215
Evidence from additional scientific databases
EMBL-EBI ChEBI
4-Methoxybenzyl alcohol
- Formula
- C8H10O2
- Average mass
- 138.166 g/mol
- Monoisotopic mass
- 138.06808 Da
- Formal charge
- 0
- benzyl alcohols — is a (CHEBI:22743)
- benzyl alcohols — is a (CHEBI:22743)
Additional curated names
Cross-references from this source
- CAS: 105-13-5 — ChemIDplus
- MANUAL_X_REF: 21105859 — ChemSpider
- MANUAL_X_REF: D77792 — KEGG DRUG
- MANUAL_X_REF: HMDB0034241 — HMDB
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 259.00 to 260.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 259 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Boiling Point: 259.1 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Density: 1.107-1.115 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 1.108 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- LogP: 1.10 Source: Human Metabolome Database (HMDB)
- Melting Point: 24 - 25 °C Source: Human Metabolome Database (HMDB)
- Melting Point: 25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Liquid; mp = 24-25 deg C; [Merck Index] White liquid or low-melting solid; mp = 22-25 deg C; [Alfa Aesar MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Physical Description: colourless to slightly yellow liquid or opaque crystalline mass with a mild, sweet, floral odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: 1.540-1.547 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 2 mg/mL at 20 °C Source: Human Metabolome Database (HMDB)
- Solubility: insoluble in water; poorly soluble in glycols, glycerol; soluble in organic solvents, oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: miscible above 20� (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 0.0038 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (97.3%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (95.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (91.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P270, P272, P280, P301+P317, P302+P352, P305+P354+P338, P317, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2001 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P264, P264+P265, P270, P272, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Consumer Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a flavoring agent; [FDA] Used to make perfumes, fragrances, fine chemicals, pharmaceuticals, photo-chemicals, cosmetics, and personal care products; [ECHA REACH Registrations] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Other restrictions
The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)g when its concentration exceeds:
- 0.001% in leave-on products
- 0.01% in rinse-off products
INCI glossary name
ANISe ALCOHOL
Chemical name
4-Methoxybenzyl alcohol
Regulatory information
SCCS opinions
- Opinion concerning Essential Oils
- Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem - Analysis of the need for appropriate Consumer Information and Identification of Consumer Allergens
- Opinion concerning the Interim Position on Fragrance Allergy
- Memorandum on the SCCNFP Opinion concerning Fragrance Allergy
Identified ingredients
EU Fragrance Allergen
This substance is linked to an EU fragrance-allergen reference. Check the current Annex III entry for the declaration threshold and any additional conditions.
Key data
Inventory links for ANISe ALCOHOL
Related records for ANISe ALCOHOL
Direct matches are limited for this record, so nearby entries from Annex III are shown as well.
Citronellol
ISOEUGENOL
What Annex III means for ANISe ALCOHOL
ANISe ALCOHOL is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Document conditions of use in the Product Information File (PIF).
- This substance is a regulated fragrance allergen. Declare it on the label by INCI name above 0.001% in leave-on or 0.01% in rinse-off products.
Frequently asked questions
Source note for Annex III record ANISe ALCOHOL
This page summarizes one Annex III record for ANISe ALCOHOL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for ANISe ALCOHOL, but confirm any final regulatory decision against the current official annex wording and source files.
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