Methyl 2-Octynoate
Methyl 2-Octynoate is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (b) 0.01% when used alone When present in combination with methyl octine carbonate, the combined level in the finished product shall not exceed 0,01 % (of which methyl octine carbonate shall not be more than 0,002 %).
This substance is on the EU list of fragrance allergens that must be named individually in the ingredient list, rather than being covered by the word "parfum", once it exceeds 0.001% in a leave-on product or 0.01% in a rinse-off product.
Declaration is a labelling duty under Article 19, not a restriction on use. See the allergen record
Chemical identity and properties
- IUPAC name
- methyl oct-2-ynoate
- Molecular formula
- C9H14O2
- Molecular weight
- 154.21 g/mol
- Exact mass
- 154.099379685 Da
- XLogP3
- 3.2
- Topological polar surface area
- 26.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:168485
- ChEMBL:CHEMBL3185035
- EPA DTXSID:DTXSID9047093
- PubMed:26795242
- PubMed:22023385
- PubMed:20495907
- PubMed:20136892
- PubMed:17162413
- PubMed:12010023
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 217.00 to 220.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 215-217 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 0.919-0.924 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Physical Description: Colourless to slightly yellow liquid; Powerful, unpleasant odour. Violet like when diluted. Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: 1.443-1.449 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: Soluble in most fixed oils; Slightly soluble in propylene glycol; Insoluble in water, glycerin Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: Soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (97.3%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (97.4%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1763 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Maximum concentration
(b) 0.01% when used alone When present in combination with methyl octine carbonate, the combined level in the finished product shall not exceed 0,01 % (of which methyl octine carbonate shall not be more than 0,002 %)
Product type
Other restrictions
(a)(b)
The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)(g) when its concentration exceeds:
- 0.001% in leave-on products
- 0.01% in rinse-off products
Chemical name
Methyl 2-Octynoate
Chemical / IUPAC name
Methyl Oct-2-ynoate; Methyl heptine carbonate
Regulatory information
SCCS opinions
- Opinion concerning Essential Oils
- Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem - Analysis of the need for appropriate Consumer Information and Identification of Consumer Allergens
- Opinion concerning the Interim Position on Fragrance Allergy
- Memorandum on the SCCNFP Opinion concerning Fragrance Allergy
- An Initial List of Perfumery Materials which must not form part of Cosmetic products except subject to the restrictions and conditions laid down
- Opinion on Clarifications to SCCNFP/0392/00 "An initial List of Perfumery Materials which must not form part of Cosmetic Products except subject to the Restrictions and Conditions laid down"
Identified ingredients
EU Fragrance Allergen
This substance is linked to an EU fragrance-allergen reference. Check the current Annex III entry for the declaration threshold and any additional conditions.
Key data
Inventory links for Methyl 2-Octynoate
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What Annex III means for Methyl 2-Octynoate
Methyl 2-Octynoate is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Ensure formulation concentration does not exceed: (b) 0.01% when used alone When present in combination with methyl octine carbonate, the combined level in the finished product shall not exceed 0,01 % (of which methyl octine carbonate shall not be more than 0,002 %)
- Confirm product type compatibility: (a) Oral products (b) Other products
- Document conditions of use in the Product Information File (PIF).
- This substance is a regulated fragrance allergen. Declare it on the label by INCI name above 0.001% in leave-on or 0.01% in rinse-off products.
Frequently asked questions
Source note for Annex III record Methyl 2-Octynoate
This page summarizes one Annex III record for Methyl 2-Octynoate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for Methyl 2-Octynoate, but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
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