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Annex III Entry 73 Allergen 11/09/2023

ISOEUGENOL

Phenol, 2-methoxy-4-(1-propenyl); (E)-2-methoxy-4-(prop-1-enyl)phenol;(trans-Isoeugenol); (Z)-2-methoxy-4-(prop-1-enyl)phenol;(cis-Isoeugenol)

ISOEUGENOL is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: b) 0,02 %.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: b) 0,02 %
Entry: 73
Allergen

Record details

Maximum concentration

b) 0,02 %

Product type

Oral products Other products

Other restrictions

(a) (b) The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds:
— 0,001 % in leave-on products
— 0,01 % in rinse-off products.

INCI glossary name

ISOEUGENOL

Chemical name

Phenol, 2-methoxy-4-(1-propenyl); (E)-2-methoxy-4-(prop-1-enyl)phenol;(trans-Isoeugenol); (Z)-2-methoxy-4-(prop-1-enyl)phenol;(cis-Isoeugenol)

Chemical / IUPAC name

Phenol, 2-methoxy-4- (1-propenyl)

Regulatory information

Regulation

(EU) 2023/1545

Identified ingredients

EU Fragrance Allergen

This substance is on the list of 26 regulated EU fragrance allergens. It must be declared on the label above threshold concentrations.

ISOEUGENOL

Key data

CAS
97-54-1; 5932-68-3; 5912-86-7
EC
202-590-7; 227-678-2; 227-633-7
Annex
III
Entry number
73

Inventory links for ISOEUGENOL

Inventory Restriction reference
Ref 34653

ISOEUGENOL

CAS: 97-54-1
EC: 202-590-7

What Annex III means for ISOEUGENOL

ISOEUGENOL is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: b) 0,02 %
  • Confirm product type compatibility: (a) Oral products (b) Other products
  • Document conditions of use in the Product Information File (PIF).
  • This substance is a regulated fragrance allergen. Declare it on the label by INCI name above 0.001% in leave-on or 0.01% in rinse-off products.

Frequently asked questions

ISOEUGENOL is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 97-54-1; 5932-68-3; 5912-86-7 is the unique numerical identifier assigned to ISOEUGENOL by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Yes. ISOEUGENOL is on the EU list of regulated fragrance allergens. It must be declared on the cosmetic product label by its INCI name when present above 0.001% in leave-on products or above 0.01% in rinse-off products, as required by EU Cosmetics Regulation 1223/2009.

The maximum concentration of b) 0,02 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record ISOEUGENOL

This page summarizes one Annex III record for ISOEUGENOL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for ISOEUGENOL, but confirm any final regulatory decision against the current official annex wording and source files.

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