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CAS 1 record

CAS 446-72-0

CAS 446-72-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 446-72-0
CAS 446-72-0PubChem CID 5280961

Genistein

Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as a geroprotector, an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a plant metabolite, a phytoestrogen and a human urinary metabolite. It is a conjugate acid of a genistein(1-). — ChEBI

IUPAC name
5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
Molecular formula
C15H10O5
Molecular weight
270.24 g/mol
Exact mass
270.05282342 Da
XLogP3
2.7
Topological polar surface area
87.0 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

Prunetol4',5,7-TrihydroxyisoflavoneGenisterinGenisteolSophoricol5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one5,7,4'-TrihydroxyisoflavoneBonistein
16 more reported names
Genestein4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one4',5, 7-TrihydroxyisoflavoneNSC-36586DH2M523P0HNPI-031LCHEBI:28088BIO-300SIPI-807-1FW-635I-25,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-oneRefChem:5853TEMPO HOT FLASH RELIEFalpha-ISOSPARTEINE, (-)-SPARTEINE L-alpha-ISOSPARTEINE
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 446-72-0

1 total
Annex
III
Entry
373

Genistein

Genisteol; 4',5,7-Trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone

From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not co…

EC
207-174-9
Max concentration

How CAS 446-72-0 is used on this site

CAS 446-72-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 446-72-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 446-72-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.
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