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InventoryRef 8518815/10/2010

GENISTEIN

5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone

GENISTEIN is linked to 1 EU annex record on this page.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Restricted entry found
Open this evidence		1English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaEvidence linked
Restricted
Open this evidence		1Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 446-72-0
CAS 446-72-0PubChem CID 5280961

Genistein

Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as a geroprotector, an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a plant metabolite, a phytoestrogen and a human urinary metabolite. It is a conjugate acid of a genistein(1-). — ChEBI

IUPAC name
5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
Molecular formula
C15H10O5
Molecular weight
270.24 g/mol
Exact mass
270.05282342 Da
XLogP3
2.7
Topological polar surface area
87.0 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

Prunetol4',5,7-TrihydroxyisoflavoneGenisterinGenisteolSophoricol5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one5,7,4'-TrihydroxyisoflavoneBonistein
16 more reported names
Genestein4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one4',5, 7-TrihydroxyisoflavoneNSC-36586DH2M523P0HNPI-031LCHEBI:28088BIO-300SIPI-807-1FW-635I-25,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-oneRefChem:5853TEMPO HOT FLASH RELIEFalpha-ISOSPARTEINE, (-)-SPARTEINE L-alpha-ISOSPARTEINE
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GENISTEIN

INCI name

GENISTEIN

Description

5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone

Record provenance

Inventory reference
85188
Imported identity
GENISTEIN
Source update
15/10/2010
European Commission CosIng source notes
Annex III Identified ingredient
Entry 373

Genistein

CAS: 446-72-0
EC: 207-174-9

Key data

CAS
446-72-0
EC
207-174-9
Restriction
—
Function
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#10875 · GENISTEIN

Ingredients with overlapping formulation functions

GEMFIBROZILOYL PENTAPEPTIDE-43SKIN CONDITIONING
GENIPA AMERICANA EXTRACTSKIN CONDITIONING
GENIPA AMERICANA FRUIT EXTRACTSKIN CONDITIONING
GENISTA TINCTORIA FLOWER/LEAF/STEM EXTRACTSKIN CONDITIONING
GENISTEIN GLUCOSIDEANTIOXIDANT, SKIN CONDITIONING
GENISTEIN METHYL ETHERHUMECTANT, SKIN CONDITIONING, SKIN PROTECTING
GENTIANA ACAULIS FLOWER/LEAF EXTRACTSKIN CONDITIONING
GENTIANA LUTEA EXTRACTSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How GENISTEIN appears in the CosIng inventory

The CosIng inventory lists GENISTEIN as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GENISTEIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GENISTEIN appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

According to the EU CosIng inventory, GENISTEIN carries the following function designation(s):

CAS 446-72-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for GENISTEIN

This page combines the CosIng inventory entry for GENISTEIN with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research GENISTEIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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