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Annex III Entry 18 17/10/2010

NITROMETHANE

Nitromethane

NITROMETHANE is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 0.3%.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: 0.3%
Entry: 18

Chemical identity and properties

PubChem 2D chemical structure for CAS 75-52-5
CAS 75-52-5PubChem CID 6375

Nitromethane

Nitromethane is a primary nitroalkane that is methane in which one of the hydrogens is replace by a nitro group. A polar solvent (b.p. 101 C), it is an important starting material in organic synthesis. It is also used as a fuel for rockets and radio-controlled models. It has a role as a NMR chemical shift reference compound, a polar aprotic solvent, an explosive and an EC 4.3.1.3 (histidine ammonia-lyase) inhibitor. It is a primary nitroalkane and a volatile organic compound. — ChEBI

IUPAC name
nitromethane
Molecular formula
CH3NO2
Molecular weight
61.040 g/mol
Exact mass
61.016378338 Da
XLogP3
0.1
Topological polar surface area
45.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

NitrocarbolMethane, nitro-NitrometanRU5WG8C3F4NSC-428NSC428CHEBI:77701RefChem:6070
16 more reported names
200-876-6CH3NO2NITROMETHANE (15N)nitro methanenitro-methaneNSC 428MeNO2Nitrometan [Polish]CCRIS 1205HSDB 106EINECS 200-876-6UN1261UNII-RU5WG8C3F4nitrometaneAI3-00111nitro- methane
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.3%

Product type

Rust inhibitor

INCI glossary name

NITROMETHANE

Chemical name

Nitromethane

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
75-52-5
EC
200-876-6
Annex
III
Entry number
18

Inventory links for NITROMETHANE

Inventory Restriction reference
Ref 35508

NITROMETHANE

CAS: 75-52-5
EC: 200-876-6

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 16
Nearby record in the same annex

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 21
Nearby record in the same annex

QUININE

CAS: 130-95-0
EC: 205-003-2
Annex III 16
Nearby record in the same annex

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 22
Nearby record in the same annex

RESORCINOL

CAS: 108-46-3
EC: 203-585-2

What Annex III means for NITROMETHANE

NITROMETHANE is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 11 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: 0.3%
  • Confirm product type compatibility: Rust inhibitor
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

NITROMETHANE is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 75-52-5 is the unique numerical identifier assigned to NITROMETHANE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.3% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record NITROMETHANE

This page summarizes one Annex III record for NITROMETHANE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for NITROMETHANE, but confirm any final regulatory decision against the current official annex wording and source files.

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