What is CAS 124-87-8 for Picrotoxin?

CAS 124-87-8 is the unique numerical identifier assigned to Picrotoxin by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 282 15/10/2010

Picrotoxin

Q: How do I check if my product formula contains Picrotoxin?

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Picrotoxin is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 282

Chemical identity and properties

PubChem 2D chemical structure for CAS 124-87-8

CAS 124-87-8PubChem CID 31304

Picrotoxin

Cocculus appears as a poisonous berry, the dried fruit of Anamirta cocculus L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent. — CAMEO Chemicals

IUPAC name: (1R,3R,5S,8S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione;(1R,5S,8S,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione

Molecular formula: C30H34O13
Molecular weight: 602.6 g/mol
Exact mass: 602.19994113 Da
Topological polar surface area: 191.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 13
Covalent units: 2
Defined stereocentres: 11

Also known as

CocculinCocculusPicrotoxinumOriental berryIndian berryPicrotoxinePicrotoxCoques du levant

16 more reported names

Picrotin, compound with picrotoxinin (1:1)EPA Pesticide Chemical Code 002301AI3-17689ZLT174DL7UNSC-403139RefChem:174201CHEBI:134126204-716-6Coques du levant [French]Caswell No. 663APicrotoxinin - picrotinPicrotoxin [NF]HSDB 6385EINECS 204-716-6UNII-ZLT174DL7UNSC 403139

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

PubMed:35137321
PubMed:34536444
PubMed:31811871
PubMed:30590068
PubMed:29596924
PubMed:29038840
PubMed:25490531
PubMed:25456265
PubMed:24482233
PubMed:21454176
PubMed:21113126
PubMed:20940032

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match31304

Attributed physical-property, hazard, environmental and use annotations.

Color/Form: Shiny rhomboid leaflets Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Colorless, shining, prismatic crystals or white or nearly white microcrystalline powder Source: Hazardous Substances Data Bank (HSDB)

LogP: -2.229 Source: DrugBank

Melting Point: 397 °F (EPA, 1998) Source: CAMEO Chemicals
Melting Point: 203.5 °C Source: DrugBank
Melting Point: 203 °C Source: Hazardous Substances Data Bank (HSDB)

Odor: Odorless Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Cocculus appears as a poisonous berry, the dried fruit of Anamirta cocculus L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent. Source: CAMEO Chemicals

Solubility: 4100 mg/L Source: DrugBank
Solubility: 1 g in 350 ml water Source: Hazardous Substances Data Bank (HSDB)
Solubility: 1 g in 5 ml boiling water (approx) Source: Hazardous Substances Data Bank (HSDB)
Solubility: 1 g in 13.5 ml 95% ethanol Source: Hazardous Substances Data Bank (HSDB)
Solubility: 1 g in 3 ml boiling alcohol (approx) Source: Hazardous Substances Data Bank (HSDB)
Solubility: For more Solubility (Complete) data for PICROTOXIN (7 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Vapor Pressure: 0.00001 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy

pH: A saturated solution in water is neutral to litmus Source: Hazardous Substances Data Bank (HSDB)

First Aid: Warning: Picrotoxin is a powerful stimulant and affects all portions of the central nervous system. Picrotoxin is a highly toxic alkaloid convulsant poison. Epileptics may be more sensitive to picrotoxin.; Signs and Symptoms of Picrotoxin Exposure: Signs and symptoms of acute exposure to picrotoxin may include slowing of pulse followed by increased pulse rate, tachycardia, and arrhythmias. Headache, salivation, sweating, dilation of pupils, loss of vision, muscle rigidity, excitement, hyperactivity, delirium, hallucinations, and convulsions may be observed. Nausea, vomiting, diarrhea, hyperpnea (excessive respiration), pulmonary edema, respiratory failure, and coma may also be noted.; Emergency Life-Support Procedures: Acute exposure to picrotoxin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.; Inhalation Exposure:; 1. Move victims to fresh Source: CAMEO Chemicals

Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 43 reports by companies from 1 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Uses: MEDICATION (VET) Source: Hazardous Substances Data Bank (HSDB)
Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Picrotoxin

Chemical / IUPAC name

3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS

124-87-8

204-716-6

Annex

Entry number

282

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 281