What is CAS 107-49-3 for Tetraethyl pyrophosphate (TEPP - ISO)?

CAS 107-49-3 is the unique numerical identifier assigned to Tetraethyl pyrophosphate (TEPP - ISO) by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 276 20/10/2010

Tetraethyl pyrophosphate (TEPP - ISO)

Q: How do I check if my product formula contains Tetraethyl pyrophosphate (TEPP - ISO)?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Tetraethyl pyrophosphate (TEPP - ISO) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 276

Chemical identity and properties

PubChem 2D chemical structure for CAS 107-49-3

CAS 107-49-3PubChem CID 7873

Tetraethyl Pyrophosphate

TEPP is an organic diphosphate. — ChEBI

IUPAC name: diethoxyphosphoryl diethyl phosphate

Molecular formula: C8H20O7P2
Molecular weight: 290.19 g/mol
Exact mass: 290.06842697 Da
XLogP3: 0.4
Topological polar surface area: 80.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 0

Also known as

TEPPTetraethyl diphosphateVapotoneBladanTetronMortopalTetrastigmineHepthexamite

16 more reported names

FosvexGrisolKillaxLirohexNifostNifosKilmite 40HexamiteKillexLethalaire G-52Tetron-100Nifos TDiphosphoric acid, tetraethyl esterEthyl pyrophosphate, tetra-Rcra waste number P111Ethyl pyrophosphate (Et4P2O7)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:82149
ChEMBL:CHEMBL293787
EPA DTXSID:DTXSID3034957
PubMed:22163587
PubMed:20872688
PubMed:20391100
PubMed:20095145
PubMed:19435147
PubMed:19379510
PubMed:18468398
PubMed:16720085
PubMed:16481169
PubMed:15908205
PubMed:11926204

Evidence from additional scientific databases

EMBL-EBI ChEBI

Exact identifier matchCHEBI:82149

TEPP

Formula: C8H20O7P2
Average mass: 290.189 g/mol
Monoisotopic mass: 290.06843 Da
Formal charge: 0

organic diphosphate — is a (CHEBI:62889)

organic diphosphate — is a (CHEBI:62889)

12383012 Source: PubMed

Additional curated names

ethyl pyrophosphateEthyl pyrophosphateNSC-14707Tetraethyl pyrophosphate

Cross-references from this source

CAS: 107-49-3 — KEGG COMPOUND
MANUAL_X_REF: 1272 — PPDB
MANUAL_X_REF: C19017 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View

Exact identifier match7873

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: 280 °F at 2.3 mmHg (EPA, 1998) Source: CAMEO Chemicals
Boiling Point: 82 °C @ 0.05 mm Hg; 124 °C @ 1.1 mm Hg; 138 °C @ 2.3 mm Hg Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: 280 °F at 2.3 mmHg Source: Occupational Safety and Health Administration (OSHA)
Boiling Point: 310 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
Boiling Point: Decomposes Source: The National Institute for Occupational Safety and Health (NIOSH)

Color/Form: Mobile liquid Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Colorless to amber liquid (Note: A solid below 32 degrees F). Source: Hazardous Substances Data Bank (HSDB)

Density: 1.185 at 68 °F (EPA, 1998) - Denser than water; will sink Source: CAMEO Chemicals
Density: 1.185 @ 20 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
Density: Density: about 1.2 @ 25 °C; dark amber-colored mobile liquid /Technical product/ Source: Hazardous Substances Data Bank (HSDB)
Density: 1.18 g/cm³ Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Density: Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.00 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Density: 1.185 Source: Occupational Safety and Health Administration (OSHA)
Density: 1.2 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
Density: 1.19 Source: The National Institute for Occupational Safety and Health (NIOSH)

Flash Point: >110 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)

LogP: 2.94 Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Melting Point: 32 °F (EPA, 1998) Source: CAMEO Chemicals
Melting Point: Solid below 32 °F Source: Hazardous Substances Data Bank (HSDB)
Melting Point: 32 °F Source: Occupational Safety and Health Administration (OSHA)
Melting Point: 32 °F Source: The National Institute for Occupational Safety and Health (NIOSH)

Odor: Agreeable odor Source: Hazardous Substances Data Bank (HSDB)
Odor: AROMATIC Source: Hazardous Substances Data Bank (HSDB)
Odor: Faint, fruity odor Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Tetraethyl pyrophosphate is an organic phosphate pesticide which acts as an inhibitor of cholinesterase, and as such it is highly toxic by all routes of exposure. It is a water-white to amber liquid, depending on purity. Tetraethyl pyrophosphate is soluble in water and is slowly decomposed by water. It is toxic by inhalation and by skin absorption. It may be found as a liquid or as a dry mixture where the liquid is absorbed onto a dry carrier. Source: CAMEO Chemicals
Physical Description: Colorless to amber liquid with a faint, fruity odor. [insecticide] [Note: A solid below 32 degrees F.]; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: COLOURLESS HYGROSCOPIC LIQUID. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Physical Description: Colorless to amber liquid with a faint, fruity odor. Source: Occupational Safety and Health Administration (OSHA)
Physical Description: Colorless to amber liquid with a faint, fruity odor. [insecticide] [Note: A solid below 32 °F.] Source: The National Institute for Occupational Safety and Health (NIOSH)

Refractive Index: Index of refraction: 1.4196 @ 20 deg C/D Source: Hazardous Substances Data Bank (HSDB)

Solubility: Miscible (decomposes) (NTP, 1992) Source: CAMEO Chemicals
Solubility: Miscible with glycerol, ethylene glycol, toluene, propylene glycol, acetone, methanol, benzene, carbon tetrachloride, xylene, ethanol, chloroform Source: Hazardous Substances Data Bank (HSDB)
Solubility: Miscible in water Source: Hazardous Substances Data Bank (HSDB)
Solubility: Solubility in water: good Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Solubility: Miscible Source: The National Institute for Occupational Safety and Health (NIOSH)

Vapor Pressure: 0.00047 mmHg at 86 °F (EPA, 1998) Source: CAMEO Chemicals
Vapor Pressure: 0.00015 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: 2.60X10-4 mm Hg at 25 °C (extrapolated from 4.7X10-4 mm Hg at 30 °C) Source: Hazardous Substances Data Bank (HSDB)
Vapor Pressure: Vapor pressure, Pa at 20 °C: 2 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Vapor Pressure: 0.0002 mmHg Source: Occupational Safety and Health Administration (OSHA)
Vapor Pressure: 0.00047 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy
Vapor Pressure: 0.0002 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)

Exposure Routes: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)

First Aid: Warning: Effects may be delayed up to 12 hours. Caution is advised.; Note: TEPP is a cholinesterase inhibitor.; Signs and Symptoms of TEPP Exposure: Acute exposure to TEPP may produce the following signs and symptoms: sweating, pinpoint pupils, blurred vision, headache, dizziness, profound weakness, muscle spasms, seizures, and coma. Mental confusion and psychosis may occur. Excessive salivation, nausea, vomiting, anorexia, diarrhea, and abdominal pain may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), pulmonary edema, respiratory depression, and respiratory paralysis.; Emergency Life-Support Procedures: Acute exposure to TEPP may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheet Source: CAMEO Chemicals
First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H300: Fatal if swallowed [Danger Acute toxicity, oral]; H310: Fatal in contact with skin [Danger Acute toxicity, dermal]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]; H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H300: Fatal if swallowed [Danger Acute toxicity, oral]; H310: Fatal in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
Precautionary Statement Codes: P260, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
GHS Hazard Statements: H300: Fatal if swallowed [Danger Acute toxicity, oral]; H310: Fatal in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Target Organs: Eyes, respiratory system, central nervous system, cardiovascular system, gastrointestinal tract, blood cholinesterase Source: The National Institute for Occupational Safety and Health (NIOSH)

Environmental Bioconcentration: An estimated BCF of 3.2 was calculated for tetraethyl pyrophosphate(SRC), using an estimated log Kow of 0.45(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC), provided the compound is not altered physically or chemically once released into the environment. Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.2(SRC), determined from a water solubility of 1.00X10+6 mg/L(2) and a regression-derived equation(3), indicates that tetraethyl pyrophosphate is expected to have very high mobility in soil(SRC). Volatilization of tetraethyl pyrophosphate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.2X10-10 atm-cu m/mole(SRC) derived from its vapor pressure, 2.60X10-4 mm Hg at 25 °C(2), and water solubility(2). Tetraethyl pyrophosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). Biodegradation data for this substance were not located in the literature. Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.2(SRC), determined from a water solubility of 1.00X10+6 mg/L(2) and a regression-derived equation(3), indicates that tetraethyl pyrophosphate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.2X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, 2.60X10-4 mm Hg at 25 °C(2), and water solubility(2). Using this Henry's Law constant and an estimation method(3). According to a classification scheme(4), an estimated BCF of 3.2(SRC), from an estimated log Kow(5) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data for this substance were not located in the literature. Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetraethyl pyrophosphate, which has a vapor pressure of 2.60X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetraethyl pyrophosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5.0 hours(SRC), calculated from its rate constant of 7.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: Aquatic or Terrestrial Fate: ... Rapidly hydrolyzed in the presence of moisture. Source: Hazardous Substances Data Bank (HSDB)

Sources/Uses: Commercially available as dust, concentrate, or solution in methyl chloride to kill aphids, spiders, mites, mealy bugs, leafhoppers, and thrips; [ACGIH] Used on vegetable and fruit crops, it is one of the first organophosphate insecticide developed and has been largely replaced by newer products. [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: For tetraethyl pyrophosphate (USEPA/OPP Pesticide Code: 079601) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: Insecticide-acaricide; used on three vegetable crops and three fruit crops; one of first organic phosphate insecticides in the US (1946); largely replaced by other products. Source: Hazardous Substances Data Bank (HSDB)
Uses: ... /It is/ used in the control of some aphids, spider mites, mealybugs, and leafhoppers and thrips. Source: Hazardous Substances Data Bank (HSDB)
Uses: Contact poison ... very effective against active stages of mites and other soft bodied insects. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
EMBL-EBI ChEBI	Exact match	2026-08-31
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Tetraethyl pyrophosphate (TEPP - ISO)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS

107-49-3

203-495-3

Annex

Entry number

276

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 275